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    Hook3 hook microtubule tethering protein 3 [ Mus musculus (house mouse) ]

    Gene ID: 320191, updated on 12-May-2024

    Summary

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    Official Symbol
    Hook3provided by MGI
    Official Full Name
    hook microtubule tethering protein 3provided by MGI
    Primary source
    MGI:MGI:2443554
    See related
    Ensembl:ENSMUSG00000037234 AllianceGenome:MGI:2443554
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5830454D03Rik; E330005F07Rik
    Summary
    Predicted to enable several functions, including cytoskeletal protein binding activity; dynein intermediate chain binding activity; and dynein light chain binding activity. Involved in negative regulation of neurogenesis. Acts upstream of or within several processes, including interkinetic nuclear migration; microtubule anchoring at centrosome; and neuronal stem cell population maintenance. Located in centriolar satellite; cytoplasm; and pericentriolar material. Is expressed in brain; future brain; and genitourinary system. Orthologous to human HOOK3 (hook microtubule tethering protein 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E14 (RPKM 5.4), whole brain E14.5 (RPKM 5.0) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Hook3 in Genome Data Viewer
    Location:
    8 A2; 8 14.29 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (26511449..26609646, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (26021421..26119618, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31402 Neighboring gene protein-O-mannose kinase Neighboring gene STARR-seq mESC enhancer starr_20994 Neighboring gene farnesyltransferase, CAAX box, alpha Neighboring gene STARR-seq mESC enhancer starr_20995 Neighboring gene STARR-seq mESC enhancer starr_20996 Neighboring gene RIKEN cDNA 1700047A11 gene Neighboring gene STARR-seq mESC enhancer starr_20998 Neighboring gene calcium binding protein 39 pseudogene Neighboring gene ring finger protein 170 Neighboring gene STARR-positive B cell enhancer ABC_E879 Neighboring gene STARR-seq mESC enhancer starr_20999 Neighboring gene THAP domain containing, apoptosis associated protein 1 Neighboring gene STARR-seq mESC enhancer starr_21000 Neighboring gene STARR-seq mESC enhancer starr_21002 Neighboring gene STARR-seq mESC enhancer starr_21003 Neighboring gene predicted gene, 31727

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The Salmonella SpiC protein targets the mammalian Hook3 protein function to alter cellular trafficking. Shotland Y, et al. Mol Microbiol, 2003 Sep. PMID 12950921
    2. IIGP, a member of the IFN inducible and microbial defense mediating 47 kDa GTPase family, interacts with the microtubule binding protein hook3. Kaiser F, et al. J Cell Sci, 2004 Apr 1. PMID 15075236
    3. Hook Adaptors Induce Unidirectional Processive Motility by Enhancing the Dynein-Dynactin Interaction. Olenick MA, et al. J Biol Chem, 2016 Aug 26. PMID 27365401, Free PMC Article
    4. The microtubule-binding protein Hook3 interacts with a cytoplasmic domain of scavenger receptor A. Sano H, et al. J Biol Chem, 2007 Mar 16. PMID 17237231
    5. Hook3 interacts with PCM1 to regulate pericentriolar material assembly and the timing of neurogenesis. Ge X, et al. Neuron, 2010 Jan 28. PMID 20152126, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Single-molecule motility assays using total internal reflection fluorescence microscopy indicate that both Hook1 and Hook3 effectively activate cytoplasmic dynein, inducing longer run lengths and higher velocities than the previously characterized dynein activator bicaudal D2 (BICD2).
      Title: Hook Adaptors Induce Unidirectional Processive Motility by Enhancing the Dynein-Dynactin Interaction.
    2. Identified hook3 as the first cooperation partner of a member of the 47 kDa GTPase protein family (IIGP) and indicated that hook3 links in an IFNgamma-inducible fashion to cytoskeleton-based membrane trafficking.
      Title: IIGP, a member of the IFN inducible and microbial defense mediating 47 kDa GTPase family, interacts with the microtubule binding protein hook3.
    3. Hook3 interacts with a cytoplasmic domain of scavenger receptor A
      Title: The microtubule-binding protein Hook3 interacts with a cytoplasmic domain of scavenger receptor A.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables dynactin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables dynein intermediate chain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables dynein light chain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables dynein light intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cytoplasmic microtubule organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoplasmic microtubule organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cytoskeleton-dependent intracellular transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in early endosome to late endosome transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endosome organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endosome to lysosome transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within interkinetic nuclear migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lysosome organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within microtubule anchoring at centrosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within neuronal stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein localization to centrosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of FHF complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of HOPS complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centriolar satellite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cis-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in pericentriolar material IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein Hook homolog 3
    Names
    hook homolog 3
    mHK3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_207659.3 → NP_997542.1  protein Hook homolog 3

      See identical proteins and their annotated locations for NP_997542.1

      Status: VALIDATED

      Source sequence(s)
      AC093366
      Consensus CDS
      CCDS22206.1
      UniProtKB/Swiss-Prot
      Q540A0, Q8BUK6, Q8BV48, Q8BW57, Q8BY41
      UniProtKB/TrEMBL
      Q5BKS5
      Related
      ENSMUSP00000046788.8, ENSMUST00000037182.14
      Conserved Domains (1) summary
      pfam05622
      Location:12 → 710
      HOOK; HOOK protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      26511449..26609646 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006509150.3 → XP_006509213.1  protein Hook homolog 3 isoform X3

      UniProtKB/TrEMBL
      Q5BKS5
      Conserved Domains (1) summary
      pfam05622
      Location:12 → 669
      HOOK; HOOK protein

    2. XM_006509148.3 → XP_006509211.1  protein Hook homolog 3 isoform X1

      UniProtKB/TrEMBL
      Q5BKS5
      Conserved Domains (1) summary
      pfam05622
      Location:12 → 712
      HOOK; HOOK protein

    3. XM_006509149.5 → XP_006509212.1  protein Hook homolog 3 isoform X2

      UniProtKB/TrEMBL
      Q5BKS5
      Conserved Domains (1) summary
      pfam05622
      Location:12 → 676
      HOOK; HOOK protein

    RNA

    1. XR_004934842.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BUK6.2 GenPept UniProtKB/Swiss-Prot:Q8BUK6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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