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    Mterf4 mitochondrial transcription termination factor 4 [ Mus musculus (house mouse) ]

    Gene ID: 69821, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Mterf4provided by MGI
    Official Full Name
    mitochondrial transcription termination factor 4provided by MGI
    Primary source
    MGI:MGI:1918355
    See related
    Ensembl:ENSMUSG00000026273 AllianceGenome:MGI:1918355
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mterfd2; 1810059A23Rik; 4933412H03Rik
    Summary
    Predicted to enable rRNA binding activity. Acts upstream of or within several processes, including mitochondrial transcription; protein targeting to mitochondrion; and ribosome assembly. Located in mitochondrion. Orthologous to human MTERF4 (mitochondrial transcription termination factor 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 7.6), CNS E14 (RPKM 6.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mterf4 in Genome Data Viewer
    Location:
    1 D; 1 47.24 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (93228927..93233601, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (93301205..93305879, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene ciliary rootlet coiled-coil, rootletin family member 2 Neighboring gene STARR-seq mESC enhancer starr_01724 Neighboring gene STARR-seq mESC enhancer starr_01726 Neighboring gene sushi, nidogen and EGF-like domains 1 Neighboring gene microRNA 6901 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:95202393-95202604 Neighboring gene predicted gene 28535 Neighboring gene 60S ribosomal protein L17 pseudogene Neighboring gene PAS domain containing serine/threonine kinase Neighboring gene STARR-positive B cell enhancer ABC_E3291 Neighboring gene STARR-positive B cell enhancer ABC_E7733

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Adipocyte MTERF4 regulates non-shivering adaptive thermogenesis and sympathetic-dependent glucose homeostasis. Castillo A, et al. Biochim Biophys Acta Mol Basis Dis, 2019 Jun 1. PMID 30690068
    2. Expression profile of mouse Mterfd2, a novel component of the mitochondrial transcription termination factor (MTERF) family. Xu Q, et al. Genes Genet Syst, 2011. PMID 22214595
    3. Transcriptomic and proteomic landscape of mitochondrial dysfunction reveals secondary coenzyme Q deficiency in mammals. Kühl I, et al. Elife, 2017 Nov 14. PMID 29132502, Free PMC Article
    4. Overexpression of MTERF4 promotes the amyloidogenic processing of APP by inhibiting ADAM10. Wang XL, et al. Biochem Biophys Res Commun, 2017 Jan 22. PMID 27894840
    5. MTERF4 regulates translation by targeting the methyltransferase NSUN4 to the mammalian mitochondrial ribosome. Cámara Y, et al. Cell Metab, 2011 May 4. PMID 21531335

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The results demonstrate that MTERF4 regulates mitochondrial protein translation and is essential for proper brown adipose tissue thermogenic activity.
      Title: Adipocyte MTERF4 regulates non-shivering adaptive thermogenesis and sympathetic-dependent glucose homeostasis.
    2. The levels of MTERF4 protein were significantly increased in the hippocampus of APP/PS1 mice, an animal model of Alzheimer's disease.
      Title: Overexpression of MTERF4 promotes the amyloidogenic processing of APP by inhibiting ADAM10.
    3. Mterfd2 might have multiple roles in organogenesis.
      Title: Expression profile of mouse Mterfd2, a novel component of the mitochondrial transcription termination factor (MTERF) family.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables double-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables rRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within camera-type eye development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within heart development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial ribosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within mitochondrial transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein targeting to mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within ribosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mitochondrial large ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transcription termination factor 4, mitochondrial
    Names
    MTERF domain containing 2
    mTERF domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310756.1 → NP_001297685.1  transcription termination factor 4, mitochondrial isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice junction at the 5' end of the last exon compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK033043, AK079098, DV058715
      Consensus CDS
      CCDS78655.1
      UniProtKB/TrEMBL
      D3Z3A2
      Related
      ENSMUSP00000108566.2, ENSMUST00000112944.8
      Conserved Domains (1) summary
      cl19765
      Location:128 → 223
      mTERF; mTERF

    2. NM_178051.4 → NP_835152.1  transcription termination factor 4, mitochondrial isoform 1

      See identical proteins and their annotated locations for NP_835152.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK033043, AK077142, DV058715
      Consensus CDS
      CCDS35671.1
      UniProtKB/Swiss-Prot
      Q8BVN4, Q99LQ0
      Related
      ENSMUSP00000027492.8, ENSMUST00000027492.14
      Conserved Domains (1) summary
      cl19765
      Location:128 → 302
      mTERF; mTERF

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      93228927..93233601 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_024463.1: Suppressed sequence

      Description
      NM_024463.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BVN4.1 GenPept UniProtKB/Swiss-Prot:Q8BVN4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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