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    Rhobtb3 Rho-related BTB domain containing 3 [ Mus musculus (house mouse) ]

    Gene ID: 73296, updated on 9-May-2024

    Summary

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    Official Symbol
    Rhobtb3provided by MGI
    Official Full Name
    Rho-related BTB domain containing 3provided by MGI
    Primary source
    MGI:MGI:1920546
    See related
    Ensembl:ENSMUSG00000021589 AllianceGenome:MGI:1920546
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA0878; 1700040C17Rik; 2610033K01Rik; 4930503C18Rik
    Summary
    Predicted to enable GTPase activity; enzyme binding activity; and purine ribonucleoside triphosphate binding activity. Acts upstream of or within male gonad development. Located in cytoplasm. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; respiratory system; and skeletal musculature. Orthologous to human RHOBTB3 (Rho related BTB domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E11.5 (RPKM 11.7), limb E14.5 (RPKM 9.8) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rhobtb3 in Genome Data Viewer
    Location:
    13 C1; 13 40.95 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (76017656..76092054, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (75869537..75943824, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene high mobility group box 2 pseudogene Neighboring gene predicted gene, 41005 Neighboring gene STARR-seq mESC enhancer starr_35051 Neighboring gene glutaredoxin Neighboring gene predicted gene, 24163 Neighboring gene WD repeat domain 77 pseudogene Neighboring gene ribosomal protein S2 pseudogene Neighboring gene spermatogenesis associated 9 Neighboring gene predicted gene, 23319

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Alterations in Platelet Alpha-Granule Secretion and Adhesion on Collagen under Flow in Mice Lacking the Atypical Rho GTPase RhoBTB3. Berger M, et al. Cells, 2019 Feb 11. PMID 30754723, Free PMC Article
    2. The complete sequence of perlecan, a basement membrane heparan sulfate proteoglycan, reveals extensive similarity with laminin A chain, low density lipoprotein-receptor, and the neural cell adhesion molecule. Noonan DM, et al. J Biol Chem, 1991 Dec 5. PMID 1744087
    3. Genomic organization and expression profile of the small GTPases of the RhoBTB family in human and mouse. Ramos S, et al. Gene, 2002 Oct 2. PMID 12426103
    4. RHOBTB3 promotes proteasomal degradation of HIFα through facilitating hydroxylation and suppresses the Warburg effect. Zhang CS, et al. Cell Res, 2015 Sep. PMID 26215701, Free PMC Article
    5. Expression analysis of mouse Rhobtb3 using a LacZ reporter and preliminary characterization of a knockout strain. Lutz J, et al. Histochem Cell Biol, 2014 Nov. PMID 24923387

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Circular RNA circRHOBTB3 inhibits ovarian cancer progression through PI3K/AKT signaling pathway.
      Title: Circular RNA circRHOBTB3 inhibits ovarian cancer progression through PI3K/AKT signaling pathway.
    2. genetic deletion of Rhobtb3 leads to subtle alterations in alpha-granule secretion and adhesion to collagen without significant effects on hemostasis in vivo.
      Title: Alterations in Platelet Alpha-Granule Secretion and Adhesion on Collagen under Flow in Mice Lacking the Atypical Rho GTPase RhoBTB3.
    3. embryo and adult gene expression profiling
      Title: Expression analysis of mouse Rhobtb3 using a LacZ reporter and preliminary characterization of a knockout strain.
    4. The authors identified MUF1 as the first substrate for RhoBTB-Cul3 ubiquitin ligase complexes.
      Title: MUF1/leucine-rich repeat containing 41 (LRRC41), a substrate of RhoBTB-dependent cullin 3 ubiquitin ligase complexes, is a predominantly nuclear dimeric protein.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP hydrolysis activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within male gonad development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde transport, endosome to Golgi ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    rho-related BTB domain-containing protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418860.1 → NP_001405789.1  rho-related BTB domain-containing protein 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC122242, AC158356

    2. NM_028493.3 → NP_082769.1  rho-related BTB domain-containing protein 3 isoform 1

      See identical proteins and their annotated locations for NP_082769.1

      Status: VALIDATED

      Source sequence(s)
      AC122242, AC158356
      Consensus CDS
      CCDS26652.1
      UniProtKB/Swiss-Prot
      Q05DP2, Q3UTS4, Q80X55, Q9CTN4, Q9CVT0
      Related
      ENSMUSP00000022078.6, ENSMUST00000022078.12
      Conserved Domains (3) summary
      smart00225
      Location:421 → 518
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00651
      Location:413 → 515
      BTB; BTB/POZ domain
      cl21455
      Location:34 → 174
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      76017656..76092054 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006517411.5 → XP_006517474.1  rho-related BTB domain-containing protein 3 isoform X2

      Conserved Domains (4) summary
      cd18357
      Location:236 → 393
      BTB1_POZ_RHOBTB3; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3)
      cd18532
      Location:471 → 553
      BACK_RHOBTB3; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3)
      cl38908
      Location:410 → 461
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      cl38936
      Location:34 → 174
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. XM_036158195.1 → XP_036014088.1  rho-related BTB domain-containing protein 3 isoform X5

      Conserved Domains (3) summary
      cd18357
      Location:42 → 199
      BTB1_POZ_RHOBTB3; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3)
      cd18360
      Location:216 → 325
      BTB2_POZ_RHOBTB3; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3)
      cd18532
      Location:335 → 417
      BACK_RHOBTB3; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3)

    3. XM_011244574.3 → XP_011242876.1  rho-related BTB domain-containing protein 3 isoform X4

      Conserved Domains (3) summary
      cd18357
      Location:102 → 259
      BTB1_POZ_RHOBTB3; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3)
      cd18360
      Location:276 → 385
      BTB2_POZ_RHOBTB3; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3)
      cd18532
      Location:395 → 477
      BACK_RHOBTB3; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3)

    4. XM_011244573.3 → XP_011242875.1  rho-related BTB domain-containing protein 3 isoform X3

      Conserved Domains (3) summary
      cd18357
      Location:140 → 297
      BTB1_POZ_RHOBTB3; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3)
      cd18360
      Location:314 → 423
      BTB2_POZ_RHOBTB3; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3)
      cd18532
      Location:433 → 515
      BACK_RHOBTB3; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CTN4.3 GenPept UniProtKB/Swiss-Prot:Q9CTN4

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