Rims4 regulating synaptic membrane exocytosis 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rims4provided by MGI
Official Full Name: regulating synaptic membrane exocytosis 4provided by MGI
Primary source: MGI:MGI:2674366
See related: Ensembl:ENSMUSG00000035226 AllianceGenome:MGI:2674366
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rim4; 6530406L02
Summary: Enables transmembrane transporter binding activity. Acts upstream of or within regulation of membrane potential. Located in synaptic membrane. Is expressed in central nervous system and retina. Orthologous to human RIMS4 (regulating synaptic membrane exocytosis 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in adrenal adult (RPKM 26.3), ovary adult (RPKM 9.1) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H3; 2 84.52 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (163701676..163760893, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (163859756..163918973, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (2)
Endonuclease-mediated (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables small GTPase binding	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter binding	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane transporter binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in calcium ion-regulated exocytosis of neurotransmitter	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within exocytosis	IEA Inferred from Electronic Annotation more info
involved_in exocytosis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neurotransmitter transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of membrane potential	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of membrane potential	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synapse organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic plasticity	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of synaptic vesicle exocytosis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of synaptic vesicle exocytosis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoskeleton of presynaptic active zone	IBA Inferred from Biological aspect of Ancestor more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in presynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in synapse	ISO Inferred from Sequence Orthology more info
located_in synaptic membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: regulating synaptic membrane exocytosis protein 4

Names: RIM 4; RIM4 gamma; rab3-interacting molecule 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001376942.1 → NP_001363871.1 regulating synaptic membrane exocytosis protein 4 isoform 2

Status: VALIDATED

Source sequence(s)

AL591542, AL731698

UniProtKB/TrEMBL

A4FUQ0

Conserved Domains (1) summary

cl14603
Location:99 → 244

C2; C2 domain
NM_183023.2 → NP_898844.1 regulating synaptic membrane exocytosis protein 4 isoform 1

See identical proteins and their annotated locations for NP_898844.1

Status: VALIDATED

Source sequence(s)

AL591542, AL731698, AY326955

Consensus CDS

CCDS17018.1

UniProtKB/Swiss-Prot

P60191

UniProtKB/TrEMBL

A4FUQ0

Related

ENSMUSP00000045637.3, ENSMUST00000044734.3

Conserved Domains (1) summary

cl14603
Location:100 → 245

C2; C2 domain