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    Hipk1 homeodomain interacting protein kinase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 365895, updated on 2-May-2024

    Summary

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    Official Symbol
    Hipk1provided by RGD
    Official Full Name
    homeodomain interacting protein kinase 1provided by RGD
    Primary source
    RGD:1304941
    See related
    Ensembl:ENSRNOG00000019333 AllianceGenome:RGD:1304941
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein serine/threonine kinase activity and protein tyrosine kinase activity. Predicted to be involved in several processes, including apoptotic signaling pathway; camera-type eye morphogenesis; and protein phosphorylation. Predicted to act upstream of or within anterior/posterior pattern specification and positive regulation of cell population proliferation. Predicted to be located in centrosome; cytosol; and nuclear speck. Predicted to be active in PML body and cytoplasm. Orthologous to human HIPK1 (homeodomain interacting protein kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 364.5), Spleen (RPKM 316.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hipk1 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (193937261..193988247, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (191248817..191299787, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (206224015..206274910, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485758 Neighboring gene uncharacterized LOC102547265 Neighboring gene olfactomedin-like 3 Neighboring gene uncharacterized LOC108350077 Neighboring gene DNA cross-link repair 1B Neighboring gene adaptor related protein complex 4 subunit beta 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cancer/testis antigen PAGE4, a regulator of c-Jun transactivation, is phosphorylated by homeodomain-interacting protein kinase 1, a component of the stress-response pathway. Mooney SM, et al. Biochemistry, 2014 Mar 18. PMID 24559171, Free PMC Article
    2. Phosphorylation-induced conformational dynamics in an intrinsically disordered protein and potential role in phenotypic heterogeneity. Kulkarni P, et al. Proc Natl Acad Sci U S A, 2017 Mar 28. PMID 28289210, Free PMC Article
    3. Characterization of cells and gene-targeted mice deficient for the p53-binding kinase homeodomain-interacting protein kinase 1 (HIPK1). Kondo S, et al. Proc Natl Acad Sci U S A, 2003 Apr 29. PMID 12702766, Free PMC Article
    4. Tumor necrosis factor alpha-induced desumoylation and cytoplasmic translocation of homeodomain-interacting protein kinase 1 are critical for apoptosis signal-regulating kinase 1-JNK/p38 activation. Li X, et al. J Biol Chem, 2005 Apr 15. PMID 15701637
    5. Involvement of the Hipk family in regulation of eyeball size, lens formation and retinal morphogenesis. Inoue T, et al. FEBS Lett, 2010 Jul 16. PMID 20579985

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in adherens junction assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adherens junction assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in anterior/posterior pattern specification IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within anterior/posterior pattern specification ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in embryonic camera-type eye morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in embryonic camera-type eye morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in embryonic retina morphogenesis in camera-type eye IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in embryonic retina morphogenesis in camera-type eye ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endothelial cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endothelial cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in extrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in extrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in iris morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in iris morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lens induction in camera-type eye IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lens induction in camera-type eye ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peptidyl-threonine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of tumor necrosis factor-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of tumor necrosis factor-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retina layer formation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retina layer formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in smoothened signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in smoothened signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within smoothened signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in PML body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in PML body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in PML body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    homeodomain-interacting protein kinase 1
    NP_001094456.1
    XP_008759642.1
    XP_038958716.1
    XP_038958717.1
    XP_038958720.2
    XP_038958721.2
    XP_038958722.2
    XP_038958723.1
    XP_063138349.1
    XP_063138350.1
    XP_063138352.1
    XP_063138353.1
    XP_063138354.1
    XP_063138355.1
    XP_063138356.1
    XP_063138357.1
    XP_063138358.1
    XP_063138359.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100986.1 → NP_001094456.1  homeodomain-interacting protein kinase 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      A4L9P5, A4L9P6
      UniProtKB/TrEMBL
      F1M8I6
      Related
      ENSRNOP00000061079.3, ENSRNOT00000056079.5
      Conserved Domains (2) summary
      PHA03247
      Location:618 → 925
      PHA03247; large tegument protein UL36; Provisional
      cd14228
      Location:174 → 528
      STKc_HIPK1; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      193937261..193988247 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063282287.1 → XP_063138357.1  homeodomain-interacting protein kinase 1 isoform X9

    2. XM_063282284.1 → XP_063138354.1  homeodomain-interacting protein kinase 1 isoform X6

    3. XM_063282280.1 → XP_063138350.1  homeodomain-interacting protein kinase 1 isoform X2

    4. XM_039102794.2 → XP_038958722.2  homeodomain-interacting protein kinase 1 isoform X11

    5. XM_039102792.2 → XP_038958720.2  homeodomain-interacting protein kinase 1 isoform X5

    6. XM_039102793.2 → XP_038958721.2  homeodomain-interacting protein kinase 1 isoform X10

    7. XM_063282279.1 → XP_063138349.1  homeodomain-interacting protein kinase 1 isoform X1

    8. XM_063282285.1 → XP_063138355.1  homeodomain-interacting protein kinase 1 isoform X7

    9. XM_063282286.1 → XP_063138356.1  homeodomain-interacting protein kinase 1 isoform X8

    10. XM_063282283.1 → XP_063138353.1  homeodomain-interacting protein kinase 1 isoform X4

      UniProtKB/TrEMBL
      F1M8I6

    11. XM_063282288.1 → XP_063138358.1  homeodomain-interacting protein kinase 1 isoform X3

    12. XM_039102789.1 → XP_038958717.1  homeodomain-interacting protein kinase 1 isoform X3

      UniProtKB/Swiss-Prot
      A4L9P5, A4L9P6
      Conserved Domains (2) summary
      PHA03247
      Location:623 → 930
      PHA03247; large tegument protein UL36; Provisional
      cd14228
      Location:174 → 528
      STKc_HIPK1; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 1

    13. XM_008761420.4 → XP_008759642.1  homeodomain-interacting protein kinase 1 isoform X8

      UniProtKB/Swiss-Prot
      A4L9P5, A4L9P6
      Conserved Domains (2) summary
      smart00220
      Location:190 → 518
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14228
      Location:174 → 528
      STKc_HIPK1; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 1

    14. XM_039102788.1 → XP_038958716.1  homeodomain-interacting protein kinase 1 isoform X3

      UniProtKB/Swiss-Prot
      A4L9P5, A4L9P6
      Conserved Domains (2) summary
      PHA03247
      Location:623 → 930
      PHA03247; large tegument protein UL36; Provisional
      cd14228
      Location:174 → 528
      STKc_HIPK1; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 1

    15. XM_063282282.1 → XP_063138352.1  homeodomain-interacting protein kinase 1 isoform X3

    16. XM_039102795.2 → XP_038958723.1  homeodomain-interacting protein kinase 1 isoform X13

      Conserved Domains (1) summary
      cl21453
      Location:1 → 154
      PKc_like; Protein Kinases, catalytic domain

    17. XM_063282289.1 → XP_063138359.1  homeodomain-interacting protein kinase 1 isoform X12

    RNA

    1. XR_010063633.1 RNA Sequence

    2. XR_005500331.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A4L9P5.1 GenPept UniProtKB/Swiss-Prot:A4L9P5

    Gene LinkOut

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