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    Nprl3 NPR3-like, GATOR1 complex subunit [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360505, updated on 2-May-2024

    Summary

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    Official Symbol
    Nprl3provided by RGD
    Official Full Name
    NPR3-like, GATOR1 complex subunitprovided by RGD
    Primary source
    RGD:1308665
    See related
    Ensembl:ENSRNOG00000020541 AllianceGenome:RGD:1308665
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mare; RGD1308665
    Summary
    Predicted to contribute to GTPase activator activity. Predicted to be involved in several processes, including TORC1 signaling; cellular response to amino acid starvation; and negative regulation of TOR signaling. Predicted to act upstream of or within circulatory system development and roof of mouth development. Predicted to be located in lysosomal membrane. Predicted to be part of GATOR1 complex. Human ortholog(s) of this gene implicated in focal epilepsy. Orthologous to human NPRL3 (NPR3 like, GATOR1 complex subunit). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 41.1), Spleen (RPKM 32.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nprl3 in Genome Data Viewer
    Location:
    10q12
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (15859739..15900261)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (15355361..15395812)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (15620824..15661332)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103693292 Neighboring gene hemoglobin subunit zeta Neighboring gene N-methylpurine-DNA glycosylase Neighboring gene rhomboid 5 homolog 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Nprl3 is required for normal development of the cardiovascular system. Kowalczyk MS, et al. Mamm Genome, 2012 Aug. PMID 22538705
    2. Regulation of mTORC1 by amino acids. Bar-Peled L, et al. Trends Cell Biol, 2014 Jul. PMID 24698685, Free PMC Article
    3. A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1. Bar-Peled L, et al. Science, 2013 May 31. PMID 23723238, Free PMC Article
    4. KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1. Wolfson RL, et al. Nature, 2017 Mar 16. PMID 28199306, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC124858

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in TORC1 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within aorta morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within cardiac muscle tissue development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to amino acid starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to amino acid starvation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of TORC1 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of autophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within roof of mouth development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within ventricular septum development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of GATOR1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of GATOR1 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    GATOR1 complex protein NPRL3
    Names
    GATOR complex protein NPRL3
    nitrogen permease regulator 3-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001394235.1 → NP_001381164.1  GATOR1 complex protein NPRL3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A0G2K0K3
      Related
      ENSRNOP00000071482.1, ENSRNOT00000089435.2
      Conserved Domains (1) summary
      cl24021
      Location:76 → 429
      NPR3; Nitrogen Permease regulator of amino acid transport activity 3

    2. NM_001394236.1 → NP_001381165.1  GATOR1 complex protein NPRL3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A6HDB0
      Conserved Domains (1) summary
      cl24021
      Location:64 → 416
      NPR3; Nitrogen Permease regulator of amino acid transport activity 3

    RNA

    1. NR_172092.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      Related
      ENSRNOT00000066430.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      15859739..15900261
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063269323.1 → XP_063125393.1  GATOR1 complex protein NPRL3 isoform X4

    2. XM_006246016.5 → XP_006246078.1  GATOR1 complex protein NPRL3 isoform X5

      UniProtKB/TrEMBL
      Q499Q8
      Conserved Domains (1) summary
      cl24021
      Location:76 → 396
      NPR3; Nitrogen Permease regulator of amino acid transport activity 3

    3. XM_006246011.4 → XP_006246073.1  GATOR1 complex protein NPRL3 isoform X1

      Conserved Domains (1) summary
      cl24021
      Location:38 → 391
      NPR3; Nitrogen Permease regulator of amino acid transport activity 3

    4. XM_039086292.2 → XP_038942220.1  GATOR1 complex protein NPRL3 isoform X2

      Conserved Domains (1) summary
      cl24021
      Location:26 → 378
      NPR3; Nitrogen Permease regulator of amino acid transport activity 3

    5. XM_063269324.1 → XP_063125394.1  GATOR1 complex protein NPRL3 isoform X6

    6. XM_063269325.1 → XP_063125395.1  GATOR1 complex protein NPRL3 isoform X7

    7. XM_006246012.5 → XP_006246074.1  GATOR1 complex protein NPRL3 isoform X3

      Conserved Domains (1) summary
      cl24021
      Location:106 → 375
      NPR3; Nitrogen Permease regulator of amino acid transport activity 3

    8. XM_039086294.2 → XP_038942222.1  GATOR1 complex protein NPRL3 isoform X8

      Conserved Domains (1) summary
      cl24021
      Location:13 → 218
      NPR3; Nitrogen Permease regulator of amino acid transport activity 3

    RNA

    1. XR_010055203.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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