Iqsec3 IQ motif and Sec7 domain ArfGEF 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Iqsec3provided by RGD
Official Full Name: IQ motif and Sec7 domain ArfGEF 3provided by RGD
Primary source: RGD:1593191
See related: Ensembl:ENSRNOG00000014083 AllianceGenome:RGD:1593191
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: sag
Summary: Predicted to enable guanyl-nucleotide exchange factor activity. Involved in activation of GTPase activity; regulation of small GTPase mediated signal transduction; and synapse organization. Is active in GABA-ergic synapse. Orthologous to human IQSEC3 (IQ motif and Sec7 domain ArfGEF 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 69.4), Adrenal (RPKM 8.3) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 4q42

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (156283040..156379396, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (154610933..154707310, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (153948052..154044493, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

we provide biochemical evidence to confirm gephyrin/IQSEC3 interaction near the IQSEC3 IQ motif, which in turn binds calmodulin at low Ca(2+) concentrations
Title: The catalytic function of the gephyrin-binding protein IQSEC3 regulates neurotransmitter-specific matching of pre- and post-synaptic structures in primary hippocampal cultures.
these data reveal that IQSEC3 acts together with gephyrin to regulate inhibitory synapse development.
Title: IQ Motif and SEC7 Domain-containing Protein 3 (IQSEC3) Interacts with Gephyrin to Promote Inhibitory Synapse Formation.
cloned from a rat brain cDNA library; both the mRNA and the protein were localized in the postsynaptic compartments; results suggest a postsynaptic role of synArfGEF in the brain
Title: Brain-specific potential guanine nucleotide exchange factor for Arf, synArfGEF (Po), is localized to postsynaptic density.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in postsynapse organization	IDA Inferred from Direct Assay more info	PubMed
involved_in postsynapse organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of ARF protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in regulation of small GTPase mediated signal transduction	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in GABA-ergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in GABA-ergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in glycinergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glycinergic synapse	ISO Inferred from Sequence Orthology more info
located_in inhibitory synapse	IEA Inferred from Electronic Annotation more info
located_in inhibitory synapse	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density	IEA Inferred from Electronic Annotation more info
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density	ISS Inferred from Sequence or Structural Similarity more info
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
located_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic specialization of symmetric synapse	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic specialization of symmetric synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: IQ motif and SEC7 domain-containing protein 3

Names: IQ motif and Sec7 domain 3; potential synaptic guanine nucleotide exchange factor for Arf; synArfGEF; synArfGEF-Po

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_207617.2 → NP_997500.2 IQ motif and SEC7 domain-containing protein 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/Swiss-Prot

Q76M68

Related

ENSRNOP00000018902.5, ENSRNOT00000018902.6

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

156283040..156379396 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063286403.1 → XP_063142473.1 IQ motif and SEC7 domain-containing protein 3 isoform X3

UniProtKB/TrEMBL

F1LPA3
XM_063286401.1 → XP_063142471.1 IQ motif and SEC7 domain-containing protein 3 isoform X1

UniProtKB/TrEMBL

F1LPA3
XM_063286402.1 → XP_063142472.1 IQ motif and SEC7 domain-containing protein 3 isoform X2

UniProtKB/TrEMBL

F1LPA3
XM_063286404.1 → XP_063142474.1 IQ motif and SEC7 domain-containing protein 3 isoform X4