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    B4galnt3 beta-1,4-N-acetyl-galactosaminyl transferase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500306, updated on 4-Apr-2024

    Summary

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    Official Symbol
    B4galnt3provided by RGD
    Official Full Name
    beta-1,4-N-acetyl-galactosaminyl transferase 3provided by RGD
    Primary source
    RGD:1561056
    See related
    Ensembl:ENSRNOG00000010344 AllianceGenome:RGD:1561056
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1561056
    Summary
    Predicted to enable acetylgalactosaminyltransferase activity. Predicted to be located in Golgi apparatus. Orthologous to human B4GALNT3 (beta-1,4-N-acetyl-galactosaminyltransferase 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 3.3), Kidney (RPKM 2.1) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See B4galnt3 in Genome Data Viewer
    Location:
    4q42
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (155081261..155181255, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (153409019..153509019, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (152736036..152835521, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene WNK lysine deficient protein kinase 1 Neighboring gene ribosomal protein S12 like 11 Neighboring gene ninjurin 2 Neighboring gene ribosomal protein L4, pseudogene 7 Neighboring gene transfer RNA alanine (anticodon AGC) 80 Neighboring gene uncharacterized LOC134486682 Neighboring gene transfer RNA leucine (anticodon AAG) 13

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and characterization of a novel human beta 1,4-N-acetylgalactosaminyltransferase, beta 4GalNAc-T3, responsible for the synthesis of N,N'-diacetyllactosediamine, galNAc beta 1-4GlcNAc. Sato T, et al. J Biol Chem, 2003 Nov 28. PMID 12966086
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acetylgalactosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acetylgalactosaminyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chondroitin sulfate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    beta-1,4-N-acetylgalactosaminyltransferase 3
    Names
    N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 2
    NP_001178905.1
    XP_006237329.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191976.3 → NP_001178905.1  beta-1,4-N-acetylgalactosaminyltransferase 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      F1M021
      Related
      ENSRNOP00000035906.6, ENSRNOT00000036721.6
      Conserved Domains (2) summary
      pfam07691
      Location:143 → 277
      PA14; PA14 domain
      cl11394
      Location:779 → 975
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      155081261..155181255 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006237267.5 → XP_006237329.1  beta-1,4-N-acetylgalactosaminyltransferase 3 isoform X1

      UniProtKB/TrEMBL
      F1M021
      Conserved Domains (2) summary
      pfam07691
      Location:153 → 287
      PA14; PA14 domain
      cl11394
      Location:788 → 984
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold
    Nucleotide Protein Strain
    Heading Accession and Version

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