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    Tnfrsf18 TNF receptor superfamily member 18 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500598, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Tnfrsf18provided by RGD
    Official Full Name
    TNF receptor superfamily member 18provided by RGD
    Primary source
    RGD:1565872
    See related
    Ensembl:ENSRNOG00000022012 AllianceGenome:RGD:1565872
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable tumor necrosis factor-activated receptor activity. Predicted to be involved in positive regulation of cell adhesion; positive regulation of leukocyte migration; and positive regulation of tyrosine phosphorylation of STAT protein. Predicted to be integral component of plasma membrane. Predicted to be active in external side of plasma membrane. Orthologous to human TNFRSF18 (TNF receptor superfamily member 18). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 38.4), Spleen (RPKM 23.8) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tnfrsf18 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (171901734..171904578)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (166618461..166622353)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (173459371..173463980)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene stromal cell derived factor 4 Neighboring gene TNF receptor superfamily member 4 Neighboring gene tubulin tyrosine ligase like 10 Neighboring gene uncharacterized LOC106182250 Neighboring gene microRNA 429 Neighboring gene microRNA 3548 Neighboring gene microRNA 200a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. In vivo fluctuation of Tax, Foxp3, CTLA-4, and GITR mRNA expression in CD4(+)CD25(+) T cells of patients with human T-lymphotropic virus type 1-associated myelopathy. Ramirez E, et al. Braz J Med Biol Res, 2010 Nov. PMID 20945034
    2. Evaluation of T Regulatory Lymphocytes Transcription Factors in HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) Patients. Ghezeldasht SA, et al. Appl Biochem Biotechnol, 2017 Aug. PMID 28101786
    3. Glucocorticoid-induced tumor necrosis factor receptor family-related ligand triggering upregulates vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 and promotes leukocyte adhesion. Lacal PM, et al. J Pharmacol Exp Ther, 2013 Oct. PMID 23892569
    4. The mutant leucine-zipper domain impairs both dimerization and suppressive function of Foxp3 in T cells. Chae WJ, et al. Proc Natl Acad Sci U S A, 2006 Jun 20. PMID 16769892, Free PMC Article
    5. Mechanistic investigation of immunosuppression in patients with condyloma acuminata. Shi YJ, et al. Mol Med Rep, 2013 Aug. PMID 23754510

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables tumor necrosis factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of leukocyte migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of tyrosine phosphorylation of STAT protein ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tumor necrosis factor-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tumor necrosis factor receptor superfamily member 18
    Names
    tumor necrosis factor receptor superfamily, member 18

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024349.2 → NP_001019520.2  tumor necrosis factor receptor superfamily member 18 precursor

      Status: VALIDATED

      Source sequence(s)
      FM088311, JAXUCZ010000005
      UniProtKB/TrEMBL
      A6IUV5, F7FFS7
      Related
      ENSRNOP00000035610.4, ENSRNOT00000038747.5
      Conserved Domains (1) summary
      cd13417
      Location:43 → 168
      TNFRSF18; Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), also known as glucocorticoid-induced tumor necrosis factor receptor family-related protein (GITR)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      171901734..171904578
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039110656.2 → XP_038966584.1  tumor necrosis factor receptor superfamily member 18 isoform X1

      Conserved Domains (2) summary
      cd00185
      Location:89 → 119
      TNFRSF; CRD1 [structural motif]
      cl22855
      Location:88 → 150
      TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
    Nucleotide Protein Strain
    Heading Accession and Version

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