Adcy5 adenylate cyclase 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Adcy5provided by RGD
Official Full Name: adenylate cyclase 5provided by RGD
Primary source: RGD:71014
See related: Ensembl:ENSRNOG00000002229 AllianceGenome:RGD:71014
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables calcium- and calmodulin-responsive adenylate cyclase activity. Involved in several processes, including adenylate cyclase-activating G protein-coupled receptor signaling pathway; cAMP biosynthetic process; and response to morphine. Located in endosome; membrane raft; and plasma membrane. Colocalizes with sarcolemma. Biomarker of hypertension and type 2 diabetes mellitus. Orthologous to human ADCY5 (adenylate cyclase 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 212.1), Brain (RPKM 104.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 11q22

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (78976861..79123343, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (65471612..65618877, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (68695839..68842452, complement)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Increased expression of adenylyl cyclases V and VI is a major determinant of increased GABAergic transmission in the substantia nigra pars reticulata of animals in which L-DOPA induces severe dyskinesia.
Title: L-DOPA-induced dyskinesia in hemiparkinsonian rats is associated with up-regulation of adenylyl cyclase type V/VI and increased GABA release in the substantia nigra reticulata.
The decrease in beta(2)-AR may account for additional relaxation impairment, given that there is no enhancement over nontransgenic after pertussis toxin, despite AC5 overexpression.
Title: Paradoxical attenuation of β2-AR function in airway smooth muscle by Gi-mediated counterregulation in transgenic mice overexpressing type 5 adenylyl cyclase.
All MOR, D1 and D2 positive cells containing AC5 mRNA simultaneously express PDE7B in striatal rat cells.
Title: Dopamine D1, D2 and mu-opioid receptors are co-expressed with adenylyl cyclase 5 and phosphodiesterase 7B mRNAs in striatal rat cells.
Describe developmental expression of adenylyl cyclase 5.
Title: Adenylyl cyclase type 5 protein expression during cardiac development and stress.
The association of AC5 with the AKAP6 complex is required for the regulation of cAMP second messenger controlling cardiac myocyte hypertrophy.
Title: An adenylyl cyclase-mAKAPbeta signaling complex regulates cAMP levels in cardiac myocytes.
Taken together, these results suggest an essential role of AC5 in the NAc for maintaining normal levels of anxiety.
Title: Adenylyl cyclase-5 activity in the nucleus accumbens regulates anxiety-related behavior.
K(ATP) channels localize adenylyl cyclase to smooth muscle membrane fractions containing caveolin. To permit protein kinase A-dependent activation, arterial K(ATP) channels need to be in the same lipid compartment as adenylyl cyclase.
Title: Caveolae localize protein kinase A signaling to arterial ATP-sensitive potassium channels.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BF406340 (e-PCR)
- UniSTS:248343

RH128707 (e-PCR)
- UniSTS:212015

stSG602571 (e-PCR)
- UniSTS:445274

D11Rat107 (e-PCR), detects polymorphism
- UniSTS:226400

RH143365 (e-PCR)
- UniSTS:232612

BE114258 (e-PCR)
- UniSTS:247461

Adcy5 (e-PCR), detects polymorphism
- UniSTS:141032

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables adenylate cyclase activity	IBA Inferred from Biological aspect of Ancestor more info
enables adenylate cyclase activity	IDA Inferred from Direct Assay more info	PubMed
enables adenylate cyclase activity	IEA Inferred from Electronic Annotation more info
enables adenylate cyclase activity	ISO Inferred from Sequence Orthology more info
enables adenylate cyclase binding	IEA Inferred from Electronic Annotation more info
enables adenylate cyclase binding	ISO Inferred from Sequence Orthology more info
enables calcium- and calmodulin-responsive adenylate cyclase activity	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables scaffold protein binding	IEA Inferred from Electronic Annotation more info
enables scaffold protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled adenosine receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within G protein-coupled adenosine receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in adenylate cyclase-activating dopamine receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within adenylate cyclase-activating dopamine receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-inhibiting dopamine receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within adenylate cyclase-inhibiting dopamine receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cAMP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in cAMP biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in cAMP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in cAMP biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in cellular response to forskolin	IEA Inferred from Electronic Annotation more info
involved_in cellular response to forskolin	ISO Inferred from Sequence Orthology more info
involved_in cellular response to forskolin	ISS Inferred from Sequence or Structural Similarity more info
involved_in heart development	IEP Inferred from Expression Pattern more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in locomotory behavior	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within locomotory behavior	ISO Inferred from Sequence Orthology more info
NOT involved_in negative regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuromuscular process controlling balance	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuromuscular process controlling balance	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of insulin secretion involved in cellular response to glucose stimulus	IEA Inferred from Electronic Annotation more info
involved_in regulation of insulin secretion involved in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info
involved_in regulation of insulin secretion involved in cellular response to glucose stimulus	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cilium	IEA Inferred from Electronic Annotation more info
located_in cilium	ISO Inferred from Sequence Orthology more info
located_in cilium	ISS Inferred from Sequence or Structural Similarity more info
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in sarcolemma	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: adenylate cyclase type 5

Names: ATP pyrophosphate-lyase 5; adenylate cyclase type V; adenylyl cyclase 5; adenylyl cyclase type V

NP_072122.2

EC 4.6.1.1

XP_017453557.1

EC 4.6.1.1

XP_038944541.1

EC 4.6.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022600.2 → NP_072122.2 adenylate cyclase type 5

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000011

UniProtKB/Swiss-Prot

Q04400

UniProtKB/TrEMBL

A6IRH3

Related

ENSRNOP00000046488.3, ENSRNOT00000049180.3

Conserved Domains (3) summary

pfam00211
Location:1063 → 1257

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam16214
Location:1 → 459

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

pfam06327
Location:669 → 761

DUF1053; Domain of Unknown Function (DUF1053)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086029.1 Reference GRCr8

Range

78976861..79123343 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039088613.2 → XP_038944541.1 adenylate cyclase type 5 isoform X1

UniProtKB/Swiss-Prot

Q04400

Conserved Domains (3) summary

pfam00211
Location:461 → 634

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam16214
Location:1 → 459

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

pfam06327
Location:669 → 761

DUF1053; Domain of Unknown Function (DUF1053)
XM_017598068.3 → XP_017453557.1 adenylate cyclase type 5 isoform X2

UniProtKB/Swiss-Prot

Q04400