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    Hs3st2 heparan sulfate-glucosamine 3-sulfotransferase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293451, updated on 30-Mar-2024

    Summary

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    Official Symbol
    Hs3st2provided by RGD
    Official Full Name
    heparan sulfate-glucosamine 3-sulfotransferase 2provided by RGD
    Primary source
    RGD:727787
    See related
    Ensembl:ENSRNOG00000017659 AllianceGenome:RGD:727787
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity. Involved in circadian rhythm. Predicted to be located in Golgi membrane. Predicted to be integral component of membrane. Human ortholog(s) of this gene implicated in colon cancer; lung cancer; and pancreatic cancer. Orthologous to human HS3ST2 (heparan sulfate-glucosamine 3-sulfotransferase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 25.4) and Heart (RPKM 1.2) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hs3st2 in Genome Data Viewer
    Location:
    1q36
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (185387445..185508700)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (175956161..176077400)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (191344979..191474143)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108349630 Neighboring gene uncharacterized LOC134483811 Neighboring gene Glyceraldehyde-3-phosphate dehydrogenase, pseudogene 59 Neighboring gene uncharacterized LOC134483814 Neighboring gene uncharacterized LOC120099923 Neighboring gene ubiquitin specific peptidase 31

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Light-induced 3-O-sulfotransferase expression alters pineal heparan sulfate fine structure. A surprising link to circadian rhythm. Kuberan B, et al. J Biol Chem, 2004 Feb 13. PMID 14630922
    2. Diurnal pineal 3-O-sulphotransferase 2 expression controlled by beta-adrenergic repression. Borjigin J, et al. J Biol Chem, 2003 May 2. PMID 12601002
    3. Methylation-associated silencing of heparan sulfate D-glucosaminyl 3-O-sulfotransferase-2 (3-OST-2) in human breast, colon, lung and pancreatic cancers. Miyamoto K, et al. Oncogene, 2003 Jan 16. PMID 12527896
    4. Integrating DNA methylation and microRNA biomarkers in sputum for lung cancer detection. Su Y, et al. Clin Epigenetics, 2016. PMID 27777637, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. 3-O sulfation catalyzed by HS 3-O-sulfotransferase (3-OST2) is predominantly restricted to daytime pineal glands in rats
      Title: Light-induced 3-O-sulfotransferase expression alters pineal heparan sulfate fine structure. A surprising link to circadian rhythm.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables [heparan sulfate]-glucosamine 3-sulfotransferase 2 activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in circadian rhythm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glycosaminoglycan biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycosaminoglycan biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in heparan sulfate proteoglycan biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    heparan sulfate glucosamine 3-O-sulfotransferase 2
    Names
    heparan sulfate (glucosamine) 3-O-sulfotransferase 2
    heparan sulfate 3-O-sulfotransferase 2
    heparan sulfate D-glucosaminyl 3-O-sulfotransferase 2
    NP_852035.1
    XP_063142029.1
    XP_063142034.1
    XP_063142038.1
    XP_063142041.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_181370.3 → NP_852035.1  heparan sulfate glucosamine 3-O-sulfotransferase 2

      See identical proteins and their annotated locations for NP_852035.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      A1A5M1, Q80W66
      UniProtKB/TrEMBL
      A6I8U4
      Related
      ENSRNOP00000023773.5, ENSRNOT00000023773.7
      Conserved Domains (1) summary
      pfam00685
      Location:114 → 351
      Sulfotransfer_1; Sulfotransferase domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      185387445..185508700
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063285959.1 → XP_063142029.1  heparan sulfate glucosamine 3-O-sulfotransferase 2 isoform X1

    2. XM_063285964.1 → XP_063142034.1  heparan sulfate glucosamine 3-O-sulfotransferase 2 isoform X2

    3. XM_063285968.1 → XP_063142038.1  heparan sulfate glucosamine 3-O-sulfotransferase 2 isoform X3

    4. XM_063285971.1 → XP_063142041.1  heparan sulfate glucosamine 3-O-sulfotransferase 2 isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80W66.1 GenPept UniProtKB/Swiss-Prot:Q80W66

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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