Aarsd1 alanyl-tRNA synthetase domain containing 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Aarsd1provided by RGD
Official Full Name: alanyl-tRNA synthetase domain containing 1provided by RGD
Primary source: RGD:1561650
See related: Ensembl:ENSRNOG00000020658 AllianceGenome:RGD:1561650
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable Ser-tRNA(Ala) hydrolase activity. Predicted to be involved in regulation of translational fidelity. Predicted to be located in cytoplasm. Orthologous to several human genes including PTGES3L-AARSD1 (PTGES3L-AARSD1 readthrough). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 78.8), Brain (RPKM 71.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q31

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (86840874..86854077, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (86340625..86353732, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (89317974..89331078, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH125015 (e-PCR)
- UniSTS:161837

RH144379 (e-PCR)
- UniSTS:233624

RH132477 (e-PCR)
- UniSTS:215760

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables Ser-tRNA(Ala) hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables Ser-tRNA(Ala) hydrolase activity	ISO Inferred from Sequence Orthology more info
enables alanine-tRNA ligase activity	IEA Inferred from Electronic Annotation more info
enables aminoacyl-tRNA editing activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in alanyl-tRNA aminoacylation	IEA Inferred from Electronic Annotation more info
involved_in aminoacyl-tRNA metabolism involved in translational fidelity	IEA Inferred from Electronic Annotation more info
involved_in regulation of translational fidelity	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of translational fidelity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: alanyl-tRNA editing protein Aarsd1

Names: alanyl-tRNA synthetase domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001034109.2 → NP_001029281.1 alanyl-tRNA editing protein Aarsd1

See identical proteins and their annotated locations for NP_001029281.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

Q5XI97

UniProtKB/TrEMBL

A6HJB3

Related

ENSRNOP00000028047.3, ENSRNOT00000028047.5

Conserved Domains (2) summary

COG2872
Location:8 → 248

AlaX; Ser-tRNA(Ala) deacylase AlaX (editing enzyme) [Translation, ribosomal structure and biogenesis]

cl08469
Location:40 → 231

tRNA_SAD; Threonyl and Alanyl tRNA synthetase second additional domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

86840874..86854077 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039086763.2 → XP_038942691.1 alanyl-tRNA editing protein Aarsd1 isoform X1

Conserved Domains (1) summary

PRK13902
Location:29 → 241

alaS; alanyl-tRNA synthetase; Provisional
XM_063269792.1 → XP_063125862.1 alanyl-tRNA editing protein Aarsd1 isoform X2