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    Rad54l2 RAD54 like 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363135, updated on 13-Apr-2024

    Summary

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    Symbol
    Rad54l2provided by RGD
    Full Name
    RAD54 like 2provided by RGD
    Primary source
    RGD:1561889
    See related
    Ensembl:ENSRNOG00000049489 AllianceGenome:RGD:1561889
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1561889
    Summary
    Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and transcription coregulator activity. Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II. Predicted to be located in nuclear speck. Predicted to be active in nucleus. Orthologous to human RAD54L2 (RAD54 like 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 91.7), Kidney (RPKM 74.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rad54l2 in Genome Data Viewer
    Location:
    8q32
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (116203655..116305723, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (107324945..107427033, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (115392891..115490640, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene glutamate metabotropic receptor 2 Neighboring gene testis expressed 264 Neighboring gene translocase of inner mitochondrial membrane 8A1, pseudogene 1 Neighboring gene DDB1 and CUL4 associated factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Dyrk1A potentiates steroid hormone-induced transcription via the chromatin remodeling factor Arip4. Sitz JH, et al. Mol Cell Biol, 2004 Jul. PMID 15199138, Free PMC Article
    2. Novel ATPase of SNF2-like protein family interacts with androgen receptor and modulates androgen-dependent transcription. Rouleau N, et al. Mol Biol Cell, 2002 Jun. PMID 12058073, Free PMC Article
    3. Analysis of oxygen/glucose-deprivation-induced changes in SUMO3 conjugation using SILAC-based quantitative proteomics. Yang W, et al. J Proteome Res, 2012 Feb 3. PMID 22082260, Free PMC Article
    4. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP hydrolysis activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP-dependent chromatin remodeler activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coregulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    helicase ARIP4
    Names
    helicase ARIP4-like
    NP_001127992.2
    XP_038937716.1
    XP_038937717.1
    XP_038937718.1
    XP_038937721.1
    XP_063121891.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134520.2 → NP_001127992.2  helicase ARIP4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I6G3P6, M0RBE0
      Related
      ENSRNOP00000066873.3, ENSRNOT00000074641.3
      Conserved Domains (3) summary
      PHA03247
      Location:1111 → 1429
      PHA03247; large tegument protein UL36; Provisional
      COG0553
      Location:133 → 906
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd18069
      Location:270 → 546
      DEXHc_ARIP4; DEXH-box helicase domain of ARIP4

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      116203655..116305723 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039081788.2 → XP_038937716.1  helicase ARIP4 isoform X1

      UniProtKB/TrEMBL
      A0A8I6G3P6, M0RBE0
      Conserved Domains (3) summary
      PHA03247
      Location:1111 → 1429
      PHA03247; large tegument protein UL36; Provisional
      COG0553
      Location:133 → 906
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd18069
      Location:270 → 546
      DEXHc_ARIP4; DEXH-box helicase domain of ARIP4

    2. XM_063265821.1 → XP_063121891.1  helicase ARIP4 isoform X1

      UniProtKB/TrEMBL
      M0RBE0

    3. XM_039081790.2 → XP_038937718.1  helicase ARIP4 isoform X1

      UniProtKB/TrEMBL
      A0A8I6G3P6, M0RBE0
      Conserved Domains (3) summary
      PHA03247
      Location:1111 → 1429
      PHA03247; large tegument protein UL36; Provisional
      COG0553
      Location:133 → 906
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd18069
      Location:270 → 546
      DEXHc_ARIP4; DEXH-box helicase domain of ARIP4

    4. XM_039081789.2 → XP_038937717.1  helicase ARIP4 isoform X1

      UniProtKB/TrEMBL
      A0A8I6G3P6, M0RBE0
      Conserved Domains (3) summary
      PHA03247
      Location:1111 → 1429
      PHA03247; large tegument protein UL36; Provisional
      COG0553
      Location:133 → 906
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd18069
      Location:270 → 546
      DEXHc_ARIP4; DEXH-box helicase domain of ARIP4

    5. XM_039081793.2 → XP_038937721.1  helicase ARIP4 isoform X2

      UniProtKB/TrEMBL
      A0A8I6G3P6
      Related
      ENSRNOP00000080821.1
      Conserved Domains (3) summary
      PHA03247
      Location:1069 → 1402
      PHA03247; large tegument protein UL36; Provisional
      COG0553
      Location:91 → 864
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd18069
      Location:228 → 504
      DEXHc_ARIP4; DEXH-box helicase domain of ARIP4
    Nucleotide Protein Strain
    Heading Accession and Version

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