Brpf3 bromodomain and PHD finger containing, 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Brpf3provided by RGD
Official Full Name: bromodomain and PHD finger containing, 3provided by RGD
Primary source: RGD:1306868
See related: Ensembl:ENSRNOG00000028641 AllianceGenome:RGD:1306868
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable histone binding activity. Predicted to be involved in histone H3-K14 acetylation and positive regulation of DNA replication. Predicted to be part of MOZ/MORF histone acetyltransferase complex. Orthologous to human BRPF3 (bromodomain and PHD finger containing 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 51.9), Testes (RPKM 29.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20p12

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (6866378..6904456)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (6864684..6902760)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (6047800..6086099)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
contributes_to histone H3K14 acetyltransferase activity	ISO Inferred from Sequence Orthology more info
contributes_to histone H4K12 acetyltransferase activity	ISO Inferred from Sequence Orthology more info
contributes_to histone H4K5 acetyltransferase activity	ISO Inferred from Sequence Orthology more info
contributes_to histone H4K8 acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA replication	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of MOZ/MORF histone acetyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of MOZ/MORF histone acetyltransferase complex	ISO Inferred from Sequence Orthology more info
part_of histone acetyltransferase complex	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: bromodomain and PHD finger-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107615.1 → NP_001101085.1 bromodomain and PHD finger-containing protein 3

See identical proteins and their annotated locations for NP_001101085.1

Status: PROVISIONAL

Source sequence(s)

CH473988

UniProtKB/TrEMBL

A0A0U1RRW8, A6JJS3, D3ZMD3

Related

ENSRNOP00000075843.1, ENSRNOT00000092629.2

Conserved Domains (6) summary

cd05839
Location:1068 → 1183

BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...

cd05512
Location:592 → 689

Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...

cd15572
Location:212 → 265

PHD_BRPF; PHD finger found in bromodomain and PHD finger-containing (BRPF) proteins

cd15703
Location:269 → 386

ePHD_BRPF3; Extended PHD finger found in bromodomain and PHD finger-containing protein 3 (BRPF3) and similar proteins

pfam10513
Location:48 → 194

EPL1; Enhancer of polycomb-like

pfam11081
Location:780 → 875

DUF2890; Protein of unknown function (DUF2890)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086038.1 Reference GRCr8

Range

6866378..6904456

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006256132.5 → XP_006256194.1 bromodomain and PHD finger-containing protein 3 isoform X4

See identical proteins and their annotated locations for XP_006256194.1

UniProtKB/TrEMBL

A0A0U1RRW8, A6JJS3, D3ZMD3

Conserved Domains (6) summary

cd05839
Location:1068 → 1183

BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...

cd05512
Location:592 → 689

Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...

cd15572
Location:212 → 265

PHD_BRPF; PHD finger found in bromodomain and PHD finger-containing (BRPF) proteins

cd15703
Location:269 → 386

ePHD_BRPF3; Extended PHD finger found in bromodomain and PHD finger-containing protein 3 (BRPF3) and similar proteins

pfam10513
Location:48 → 194

EPL1; Enhancer of polycomb-like

pfam11081
Location:780 → 875

DUF2890; Protein of unknown function (DUF2890)
XM_006256129.4 → XP_006256191.1 bromodomain and PHD finger-containing protein 3 isoform X1

Conserved Domains (6) summary

cd05839
Location:1197 → 1312

BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...

cd05512
Location:721 → 818

Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...

cd15572
Location:341 → 394

PHD_BRPF; PHD finger found in bromodomain and PHD finger-containing (BRPF) proteins

cd15703
Location:398 → 515

ePHD_BRPF3; Extended PHD finger found in bromodomain and PHD finger-containing protein 3 (BRPF3) and similar proteins

pfam10513
Location:177 → 323

EPL1; Enhancer of polycomb-like

pfam11081
Location:909 → 1004

DUF2890; Protein of unknown function (DUF2890)
XM_039098703.2 → XP_038954631.1 bromodomain and PHD finger-containing protein 3 isoform X2

UniProtKB/TrEMBL

D3ZMD3

Conserved Domains (4) summary

cd05512
Location:721 → 818

Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...

COG5141
Location:246 → 732

COG5141; PHD zinc finger-containing protein [General function prediction only]

cd15703
Location:398 → 515

ePHD_BRPF3; Extended PHD finger found in bromodomain and PHD finger-containing protein 3 (BRPF3) and similar proteins

cl02554
Location:1197 → 1268

PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...
XM_039098704.2 → XP_038954632.1 bromodomain and PHD finger-containing protein 3 isoform X3

UniProtKB/TrEMBL

D3ZMD3

Conserved Domains (4) summary

cd05512
Location:721 → 818

Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...

PHA03307
Location:812 → 1225

PHA03307; transcriptional regulator ICP4; Provisional

COG5141
Location:246 → 732

COG5141; PHD zinc finger-containing protein [General function prediction only]

cd15703
Location:398 → 515

ePHD_BRPF3; Extended PHD finger found in bromodomain and PHD finger-containing protein 3 (BRPF3) and similar proteins
XM_039098705.2 → XP_038954633.1 bromodomain and PHD finger-containing protein 3 isoform X5

Conserved Domains (3) summary

cd05512
Location:721 → 818

Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...

COG5141
Location:246 → 732

COG5141; PHD zinc finger-containing protein [General function prediction only]

cd15703
Location:398 → 515

ePHD_BRPF3; Extended PHD finger found in bromodomain and PHD finger-containing protein 3 (BRPF3) and similar proteins
XM_039098706.2 → XP_038954634.1 bromodomain and PHD finger-containing protein 3 isoform X6

Conserved Domains (2) summary

COG5141
Location:246 → 758

COG5141; PHD zinc finger-containing protein [General function prediction only]

cl22851
Location:398 → 515

PHD_SF; PHD finger superfamily
XM_039098707.2 → XP_038954635.1 bromodomain and PHD finger-containing protein 3 isoform X7

Conserved Domains (2) summary

COG5141
Location:246 → 751

COG5141; PHD zinc finger-containing protein [General function prediction only]

cl22851
Location:398 → 515

PHD_SF; PHD finger superfamily
XM_039098708.2 → XP_038954636.1 bromodomain and PHD finger-containing protein 3 isoform X8

Conserved Domains (3) summary

cd05839
Location:570 → 685

BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...

cd05512
Location:94 → 191

Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...

PHA03307
Location:185 → 542

PHA03307; transcriptional regulator ICP4; Provisional