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    Hacd1 3-hydroxyacyl-CoA dehydratase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 680115, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Hacd1provided by RGD
    Official Full Name
    3-hydroxyacyl-CoA dehydratase 1provided by RGD
    Primary source
    RGD:1595507
    See related
    Ensembl:ENSRNOG00000043192 AllianceGenome:RGD:1595507
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ptpla
    Summary
    Predicted to enable enzyme binding activity; hydro-lyase activity; and hydroxyapatite binding activity. Predicted to be involved in several processes, including cementum mineralization; fatty acid biosynthetic process; and positive regulation of cell-substrate adhesion. Predicted to act upstream of or within myotube differentiation; regulation of G1/S transition of mitotic cell cycle; and regulation of G2/M transition of mitotic cell cycle. Predicted to be located in endoplasmic reticulum. Predicted to be integral component of endoplasmic reticulum membrane. Orthologous to human HACD1 (3-hydroxyacyl-CoA dehydratase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Muscle (RPKM 294.3), Heart (RPKM 186.2) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hacd1 in Genome Data Viewer
    Location:
    17q12.3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (81992284..82014676, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (77081508..77106114, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (81173238..81196012, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene vimentin Neighboring gene ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 Neighboring gene signal transducing adaptor molecule Neighboring gene transmembrane protein 236

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Human recombinant cementum attachment protein (hrPTPLa/CAP) promotes hydroxyapatite crystal formation in vitro and bone healing in vivo. Montoya G, et al. Bone, 2014 Dec. PMID 25263524
    2. Isolation of protein-tyrosine phosphatase-like member-a variant from cementum. Valdés De Hoyos A, et al. J Dent Res, 2012 Feb. PMID 22067203, Free PMC Article
    3. Protein tyrosine phosphatase-like A regulates myoblast proliferation and differentiation through MyoG and the cell cycling signaling pathway. Lin X, et al. Mol Cell Biol, 2012 Jan. PMID 22106411, Free PMC Article
    4. Characterization of four mammalian 3-hydroxyacyl-CoA dehydratases involved in very long-chain fatty acid synthesis. Ikeda M, et al. FEBS Lett, 2008 Jul 9. PMID 18554506
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3-hydroxyacyl-CoA dehydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3-hydroxyacyl-CoA dehydratase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydroxyapatite binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cementum mineralization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fatty acid elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid elongation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within myotube differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell-substrate adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of G2/M transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sphingolipid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sphingolipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in very long-chain fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in very long-chain fatty acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1
    Names
    protein tyrosine phosphatase-like (proline instead of catalytic arginine), member a
    protein tyrosine phosphatase-like protein A
    protein-tyrosine phosphatase-like member A
    NP_001094471.1
    XP_038951987.1
    XP_038951988.1
    XP_038951989.1
    XP_063132800.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001101001.1 → NP_001094471.1  very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1

      See identical proteins and their annotated locations for NP_001094471.1

      Status: PROVISIONAL

      Source sequence(s)
      AM260199
      UniProtKB/TrEMBL
      A0A8I5ZQB2, A1IVX5
      Related
      ENSRNOP00000080696.1, ENSRNOT00000099131.1
      Conserved Domains (1) summary
      pfam04387
      Location:79 → 238
      PTPLA; Protein tyrosine phosphatase-like protein, PTPLA

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      81992284..82014676 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063276730.1 → XP_063132800.1  very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1 isoform X3

    2. XM_039096059.2 → XP_038951987.1  very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZQB2
      Conserved Domains (1) summary
      pfam04387
      Location:79 → 228
      PTPLA; Protein tyrosine phosphatase-like protein, PTPLA

    3. XM_039096060.2 → XP_038951988.1  very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1 isoform X2

      UniProtKB/TrEMBL
      F1LSK3
      Conserved Domains (1) summary
      pfam04387
      Location:79 → 229
      PTPLA; Protein tyrosine phosphatase-like protein, PTPLA

    4. XM_039096061.2 → XP_038951989.1  very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1 isoform X4

      Conserved Domains (1) summary
      cl02156
      Location:79 → 119
      PTPLA; Protein tyrosine phosphatase-like protein, PTPLA

    RNA

    1. XR_005495327.2 RNA Sequence

    2. XR_005495330.2 RNA Sequence

    3. XR_005495329.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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