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    Tmem45a transmembrane protein 45A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100911041, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Tmem45aprovided by RGD
    Official Full Name
    transmembrane protein 45Aprovided by RGD
    Primary source
    RGD:6495353
    See related
    Ensembl:ENSRNOG00000042975 AllianceGenome:RGD:6495353
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tmem45al
    Summary
    Predicted to be integral component of membrane. Orthologous to human TMEM45A (transmembrane protein 45A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 71.1), Uterus (RPKM 36.9) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tmem45a in Genome Data Viewer
    Location:
    11q12
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (57181686..57268630)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (43713309..43799526)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (46009216..46093969)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene leukemia NUP98 fusion partner 1 Neighboring gene programmed cell death 6 interacting protein, pseudogene Neighboring gene transcription elongation factor A like 9, pseudogene 1 Neighboring gene ubiquitin-ribosomal protein eS31 fusion protein-like Neighboring gene ribosomal protein S27a, pseudogene 21 Neighboring gene adhesion G protein-coupled receptor G7 Neighboring gene uncharacterized LOC134481066 Neighboring gene trafficking from ER to golgi regulator

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. TMEM45A is involved in renal fibrosis in rats by regulating Jagged1/Notch pathway. Lan JZ, et al. Front Biosci (Landmark Ed), 2020 Jan 1. PMID 31585906

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TMEM45A is involved in renal fibrosis in rats by regulating Jagged1/Notch pathway.
      Title: TMEM45A is involved in renal fibrosis in rats by regulating Jagged1/Notch pathway.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 45A
    Names
    transmembrane protein 45A-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001350002.1 → NP_001336931.1  transmembrane protein 45A

      Status: VALIDATED

      Source sequence(s)
      FM117101, FN804690, JAXUCZ010000011
      UniProtKB/TrEMBL
      D4AAI6
      Related
      ENSRNOP00000002233.3, ENSRNOT00000002233.6
      Conserved Domains (1) summary
      pfam04819
      Location:121 → 238
      DUF716; Family of unknown function (DUF716)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      57181686..57268630
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039087884.2 → XP_038943812.1  transmembrane protein 45A isoform X1

      Conserved Domains (1) summary
      pfam04819
      Location:121 → 238
      DUF716; Family of unknown function (DUF716)

    2. XM_039087886.2 → XP_038943814.1  transmembrane protein 45A isoform X2

      UniProtKB/TrEMBL
      M0R8F1
      Related
      ENSRNOP00000065747.2
      Conserved Domains (1) summary
      pfam04819
      Location:121 → 238
      DUF716; Family of unknown function (DUF716)

    3. XM_063270229.1 → XP_063126299.1  transmembrane protein 45A isoform X1

    4. XM_039087885.2 → XP_038943813.1  transmembrane protein 45A isoform X1

      Conserved Domains (1) summary
      pfam04819
      Location:121 → 238
      DUF716; Family of unknown function (DUF716)

    5. XM_063270228.1 → XP_063126298.1  transmembrane protein 45A isoform X3

      UniProtKB/TrEMBL
      D4AAI6
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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