Cish cytokine inducible SH2-containing protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cishprovided by RGD
Official Full Name: cytokine inducible SH2-containing proteinprovided by RGD
Primary source: RGD:69261
See related: Ensembl:ENSRNOG00000029543 AllianceGenome:RGD:69261
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cis
Summary: Predicted to enable 1-phosphatidylinositol-3-kinase regulator activity. Involved in cytokine-mediated signaling pathway. Predicted to be located in plasma membrane. Predicted to be part of phosphatidylinositol 3-kinase complex. Human ortholog(s) of this gene implicated in malaria and tuberculosis. Orthologous to human CISH (cytokine inducible SH2 containing protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 73.1), Heart (RPKM 57.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q32

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (116850969..116855917)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (107972306..107977254)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (116054547..116059494)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

during lactation, STAT5 signaling is reduced and CIS is upregulated in tuberoinfundibular dopaminergic neurons
Title: Mechanisms underlying the diminished sensitivity to prolactin negative feedback during lactation: reduced STAT5 signaling and up-regulation of cytokine-inducible SH2 domain-containing protein (CIS) expression in tuberoinfundibular dopaminergic neurons.
The growth hormone(GH)-responsive rat liver cell line CWSV-1 was used to investigate the role of CIS and the proteasome in GH-induced GHR internalization.
Title: Role of the cytokine-induced SH2 domain-containing protein CIS in growth hormone receptor internalization.
inhibition of GH-induced expression in osteoblast-like cells
Title: 1Alpha,25-dihydroxyvitamin D3 inhibits GH-induced expression of SOCS-3 and CIS and prolongs growth hormone signaling via the Janus kinase (JAK2)/signal transducers and activators of transcription (STAT5) system in osteoblast-like cells.
HGH acts directly on the neurons in the hypothalamus, and increases SOCS3 and CIS mRNAs, suggesting that these negative regulators may be involved in the mechanism that turns off the hGH action in the hypothalamic neurons.
Title: Human growth hormone induces SOCS3 and CIS mRNA increase in the hypothalamic neurons of hypophysectomized rats.
Thrombin-stimulation of reactive oxygen species, prostaglandin and leukotriene production in astrocytes results in cytokine-induced SH2 protein [CIS] expression which may be a feedback mechanism preventing prolonged inflammatory responses
Title: Thrombin induces expression of cytokine-induced SH2 protein (CIS) in rat brain astrocytes: involvement of phospholipase A2, cyclooxygenase, and lipoxygenase.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC156147P14 (e-PCR)
- UniSTS:271373

PMC156147P15 (e-PCR)
- UniSTS:271374

BE107841 (e-PCR)
- UniSTS:247089

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol-3-kinase regulator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cytokine-mediated signaling pathway	IEP Inferred from Expression Pattern more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of signal transduction	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein kinase C-activating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein kinase C-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of phosphatidylinositol 3-kinase complex	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cytokine-inducible SH2-containing protein

Names: CIS-1; SOCS; cytokine inducible SH2-containing protein 1; suppressor of cytokine signaling

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031804.1 → NP_113992.1 cytokine-inducible SH2-containing protein

See identical proteins and their annotated locations for NP_113992.1

Status: PROVISIONAL

Source sequence(s)

BC161930

UniProtKB/Swiss-Prot

O70512, Q9ERQ1

UniProtKB/TrEMBL

B1WBX9, F7F2E8

Related

ENSRNOP00000041734.3, ENSRNOT00000040056.5

Conserved Domains (2) summary

cd10718
Location:77 → 164

SH2_CIS; Src homology 2 (SH2) domain found in cytokine-inducible SH2-containing protein (CIS)

cd03734
Location:217 → 257

SOCS_CIS1; SOCS (suppressors of cytokine signaling) box of CIS (cytokine-inducible SH2 protein) 1-like proteins. Together with the SOCS proteins, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. ...