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    Bbip1 BBSome interacting protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100910342, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Bbip1provided by RGD
    Official Full Name
    BBSome interacting protein 1provided by RGD
    Primary source
    RGD:6498801
    See related
    AllianceGenome:RGD:6498801
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in cilium assembly and receptor localization to non-motile cilium. Predicted to act upstream of or within eating behavior. Predicted to be located in cytoplasm. Predicted to be part of BBSome. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome 18. Orthologous to human BBIP1 (BBSome interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 72.7), Testes (RPKM 64.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Bbip1 in Genome Data Viewer
    Location:
    1q55
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (262950459..262964410, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (252943589..252959512, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (274649085..274663544, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene RNA binding motif protein 20 Neighboring gene uncharacterized LOC120100058 Neighboring gene programmed cell death 4 Neighboring gene small nucleolar RNA SNORA20 Neighboring gene uncharacterized LOC134484116 Neighboring gene SHOC2 leucine-rich repeat scaffold protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Neuropeptide Y family receptors traffic via the Bardet-Biedl syndrome pathway to signal in neuronal primary cilia. Loktev AV, et al. Cell Rep, 2013 Dec 12. PMID 24316073
    2. A BBSome subunit links ciliogenesis, microtubule stability, and acetylation. Loktev AV, et al. Dev Cell, 2008 Dec. PMID 19081074
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within eating behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within erythrocyte homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within leukocyte homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within lymphocyte homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within myeloid cell homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in receptor localization to non-motile cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within receptor localization to non-motile cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of BBSome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of BBSome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ciliary membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    BBSome-interacting protein 1
    Names
    BBSome-interacting protein 1-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001401715.1 → NP_001388644.1  BBSome-interacting protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A0G2JT03, A6JHW9

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      262950459..262964410 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063283705.1 → XP_063139775.1  BBSome-interacting protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JT03, A6JHW9

    2. XM_039101442.2 → XP_038957370.1  BBSome-interacting protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JT03, A6JHW9
      Conserved Domains (1) summary
      pfam14777
      Location:10 → 64
      BBIP10; Cilia BBSome complex subunit 10

    3. XM_039101443.2 → XP_038957371.1  BBSome-interacting protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JT03, A6JHW9
      Conserved Domains (1) summary
      pfam14777
      Location:10 → 64
      BBIP10; Cilia BBSome complex subunit 10

    4. XM_039101444.2 → XP_038957372.1  BBSome-interacting protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JT03, A6JHW9
      Conserved Domains (1) summary
      pfam14777
      Location:10 → 64
      BBIP10; Cilia BBSome complex subunit 10

    5. XM_063283749.1 → XP_063139819.1  BBSome-interacting protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JT03, A6JHW9
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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