Umps uridine monophosphate synthetase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Umpsprovided by RGD
Official Full Name: uridine monophosphate synthetaseprovided by RGD
Primary source: RGD:1311908
See related: Ensembl:ENSRNOG00000001797 AllianceGenome:RGD:1311908
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables orotate phosphoribosyltransferase activity and orotidine-5'-phosphate decarboxylase activity. Involved in several processes, including UMP biosynthetic process; female pregnancy; and lactation. Predicted to be located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in orotic aciduria and purine-pyrimidine metabolic disorder. Orthologous to human UMPS (uridine monophosphate synthetase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 291.8), Thymus (RPKM 219.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 11q22

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (80311269..80321678)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (66806107..66816520)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (70034181..70044590)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables orotate phosphoribosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables orotate phosphoribosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables orotate phosphoribosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables orotidine-5'-phosphate decarboxylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables orotidine-5'-phosphate decarboxylase activity	IDA Inferred from Direct Assay more info	PubMed
enables orotidine-5'-phosphate decarboxylase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in 'de novo' UMP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in 'de novo' UMP biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in 'de novo' pyrimidine nucleobase biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in UDP biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in UMP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in UMP biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in UMP biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in cellular response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in female pregnancy	IEP Inferred from Expression Pattern more info	PubMed
involved_in lactation	IEP Inferred from Expression Pattern more info	PubMed
involved_in pyrimidine nucleobase biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: uridine 5'-monophosphate synthase

Names: uridine monophosphate synthase

NP_001020573.1

EC 2.4.2.10

EC 4.1.1.23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025402.1 → NP_001020573.1 uridine 5'-monophosphate synthase

See identical proteins and their annotated locations for NP_001020573.1

Status: PROVISIONAL

Source sequence(s)

BC098033

UniProtKB/TrEMBL

A0A8I6A354, A6IRJ8, F7FPV0, Q4QQS7

Related

ENSRNOP00000085385.1, ENSRNOT00000117390.1

Conserved Domains (2) summary

pfam00215
Location:252 → 466

OMPdecase; Orotidine 5'-phosphate decarboxylase / HUMPS family

cl00309
Location:9 → 204

PRTases_typeI; Phosphoribosyl transferase (PRT)-type I domain