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    Stk38 serine/threonine kinase 38 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361813, updated on 2-May-2024

    Summary

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    Official Symbol
    Stk38provided by RGD
    Official Full Name
    serine/threonine kinase 38provided by RGD
    Primary source
    RGD:1309455
    See related
    Ensembl:ENSRNOG00000000519 AllianceGenome:RGD:1309455
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including ATP binding activity; magnesium ion binding activity; and mitogen-activated protein kinase kinase kinase binding activity. Predicted to be involved in intracellular signal transduction; negative regulation of MAP kinase activity; and peptidyl-serine phosphorylation. Predicted to be located in cytosol and nucleus. Orthologous to human STK38 (serine/threonine kinase 38). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 188.9), Spleen (RPKM 157.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Stk38 in Genome Data Viewer
    Location:
    20p12
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (7035923..7070657, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (7034245..7067803, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (6224300..6257613, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene peroxisomal testis enriched protein 1 Neighboring gene potassium channel tetramerization domain containing 20 Neighboring gene uncharacterized LOC134483866 Neighboring gene serine and arginine rich splicing factor 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and characterization of a conserved nuclear serine(threonine) protein kinase. Millward T, et al. Proc Natl Acad Sci U S A, 1995 May 23. PMID 7761441, Free PMC Article
    2. Mechanism of Ca2+-mediated regulation of NDR protein kinase through autophosphorylation and phosphorylation by an upstream kinase. Tamaskovic R, et al. J Biol Chem, 2003 Feb 28. PMID 12493777
    3. Negative regulation of MEKK1/2 signaling by serine-threonine kinase 38 (STK38). Enomoto A, et al. Oncogene, 2008 Mar 20. PMID 17906693
    4. Chemical genetic identification of NDR1/2 kinase substrates AAK1 and Rabin8 Uncovers their roles in dendrite arborization and spine development. Ultanir SK, et al. Neuron, 2012 Mar 22. PMID 22445341, Free PMC Article
    5. E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Guo Z, et al. Sci Signal, 2014 Dec 2. PMID 25468996, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC109574

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables UFM1-modified protein reader activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone reader activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mitogen-activated protein kinase kinase kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in postsynapse organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in postsynapse organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein modification process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in site of double-strand break ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase 38
    NP_001385920.1
    XP_006256201.3
    XP_063135293.1
    XP_063135294.1
    XP_063135295.1
    XP_063135296.1
    XP_063135297.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001398991.1 → NP_001385920.1  serine/threonine-protein kinase 38

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/TrEMBL
      A6JJT1
      Related
      ENSRNOP00000075924.2, ENSRNOT00000092489.2
      Conserved Domains (1) summary
      cd05628
      Location:87 → 462
      STKc_NDR1; Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      7035923..7070657 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063279224.1 → XP_063135294.1  serine/threonine-protein kinase 38 isoform X2

    2. XM_006256139.5 → XP_006256201.3  serine/threonine-protein kinase 38 isoform X4

      UniProtKB/TrEMBL
      G3V9Q4, Q5BJM9

    3. XM_063279225.1 → XP_063135295.1  serine/threonine-protein kinase 38 isoform X3

    4. XM_063279223.1 → XP_063135293.1  serine/threonine-protein kinase 38 isoform X1

    5. XM_063279227.1 → XP_063135297.1  serine/threonine-protein kinase 38 isoform X5

    6. XM_063279226.1 → XP_063135296.1  serine/threonine-protein kinase 38 isoform X5

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001015025.1: Suppressed sequence

      Description
      NM_001015025.1: This RefSeq was removed because currently there is insufficient support for the transcript.
    Nucleotide Protein Strain
    Heading Accession and Version

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