Gdf6 growth differentiation factor 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gdf6provided by RGD
Official Full Name: growth differentiation factor 6provided by RGD
Primary source: RGD:620104
See related: Ensembl:ENSRNOG00000067800 AllianceGenome:RGD:620104
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: gdf16; BMP-13
Summary: Predicted to enable cytokine activity and identical protein binding activity. Predicted to be involved in several processes, including positive regulation of chondrocyte differentiation; positive regulation of signal transduction; and transmembrane receptor protein serine/threonine kinase signaling pathway. Predicted to act upstream of or within with a positive effect on cell migration involved in metanephros development. Predicted to act upstream of or within positive regulation of neuron differentiation. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including Klippel-Feil syndrome 1; Leber congenital amaurosis 17; cleft lip; isolated microphthalmia 4; and multiple synostoses syndrome. Orthologous to human GDF6 (growth differentiation factor 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 8.0), Lung (RPKM 3.9) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q13

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (27793561..27809884)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (22996246..23012567)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (23056345..23072666)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

expression regulated during tendon healing
Title: Treatment with rhBMP12 or rhBMP13 increase the rate and the quality of rat Achilles tendon repair.
involved in the formation of periodontal ligament
Title: Gene expression of growth differentiation factors in the developing periodontium of rat molars.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in BMP signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within BMP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in BMP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in BMP signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in SMAD protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in SMAD protein signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in activin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within_positive_effect cell migration involved in metanephros development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within_positive_effect epithelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in fat cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within_positive_effect metanephros development	ISO Inferred from Sequence Orthology more info
involved_in metanephros development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of SMAD protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of SMAD protein signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of chondrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chondrocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of p38MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of p38MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in retinal cell apoptotic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: growth/differentiation factor 6

Names: GDF-6; bone morphogenetic protein 13; growth differentiation factor 16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013038.1 → NP_001013056.1 growth/differentiation factor 6 precursor

See identical proteins and their annotated locations for NP_001013056.1

Status: PROVISIONAL

Source sequence(s)

AJ537426

UniProtKB/Swiss-Prot

Q6HA10, Q8K4X4

UniProtKB/TrEMBL

A6JFR8

Related

ENSRNOP00000082414.1, ENSRNOT00000101359.1

Conserved Domains (2) summary

pfam00019
Location:350 → 451

TGF_beta; Transforming growth factor beta like domain

pfam00688
Location:66 → 282

TGFb_propeptide; TGF-beta propeptide