Ccn6 cellular communication network factor 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ccn6provided by RGD
Official Full Name: cellular communication network factor 6provided by RGD
Primary source: RGD:1564120
See related: Ensembl:ENSRNOG00000000597 AllianceGenome:RGD:1564120
Gene type: protein coding
RefSeq status: INFERRED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Wisp3; RGD1564120
Summary: Predicted to enable heparin binding activity and integrin binding activity. Predicted to be involved in several processes, including negative regulation of cell death; regulation of mitochondrial membrane potential; and regulation of reactive oxygen species biosynthetic process. Predicted to act upstream of or within negative regulation of angiogenesis and negative regulation of cell population proliferation. Predicted to be located in extracellular space and mitochondrion. Predicted to be active in extracellular matrix. Human ortholog(s) of this gene implicated in progressive pseudorheumatoid arthropathy of childhood. Orthologous to human CCN6 (cellular communication network factor 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 53.2), Spleen (RPKM 12.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20q12

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (44123932..44139745, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (42569309..42585126, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (44237491..44255064, complement)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

WISP3 was an anti-fibrotic factor in fibroblast-myofibroblast transdifferentiation.
Title: WISP3 prevents fibroblast-myofibroblast transdifferentiation in NRK-49F cells.

Submit: New GeneRIF Correction

General gene information

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Markers

Wisp3 (e-PCR), detects polymorphism
- UniSTS:527129

AI013034 (e-PCR)
- UniSTS:250149

RH129238 (e-PCR)
- UniSTS:212546

AI577391 (e-PCR)
- UniSTS:261224

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables heparin binding	IBA Inferred from Biological aspect of Ancestor more info
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of mitochondrial membrane potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of reactive oxygen species biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cellular communication network factor 6

Names: WNT1 inducible signaling pathway protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001170483.1 → NP_001163954.1 cellular communication network factor 6 precursor

Status: INFERRED

Source sequence(s)

JAXUCZ010000020

UniProtKB/TrEMBL

D3ZDL5

Related

ENSRNOP00000000735.5, ENSRNOT00000000735.6

Conserved Domains (2) summary

pfam00219
Location:48 → 100

IGFBP; Insulin-like growth factor binding protein

cl21545
Location:275 → 342

GHB_like; Glycoprotein hormone beta chain homologues

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086038.1 Reference GRCr8

Range

44123932..44139745 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039099026.2 → XP_038954954.1 cellular communication network factor 6 isoform X1

Conserved Domains (2) summary

pfam19035
Location:132 → 175

TSP1_CCN; CCN3 Nov like TSP1 domain

cl21545
Location:198 → 265

GHB_like; Glycoprotein hormone beta chain homologues