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    Sh3bp2 SH3-domain binding protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305450, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Sh3bp2provided by RGD
    Official Full Name
    SH3-domain binding protein 2provided by RGD
    Primary source
    RGD:1310588
    See related
    Ensembl:ENSRNOG00000013747 AllianceGenome:RGD:1310588
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable SH3 domain binding activity and phosphotyrosine residue binding activity. Predicted to be involved in signal transduction. Human ortholog(s) of this gene implicated in cherubism. Orthologous to human SH3BP2 (SH3 domain binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 55.3), Liver (RPKM 25.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sh3bp2 in Genome Data Viewer
    Location:
    14q21
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (80400685..80437887, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (76176097..76213300, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (81435445..81473013, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene NOP14 nucleolar protein Neighboring gene major facilitator superfamily domain containing 10 Neighboring gene adducin 1 Neighboring gene uncharacterized LOC120096505 Neighboring gene U1 spliceosomal RNA Neighboring gene TNFAIP3 interacting protein 2 Neighboring gene family with sequence similarity 193, member A Neighboring gene U6 snRNA-associated Sm-like protein LSm3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Overexpression of DEL-1 Downregulates SH3BP2 Expression and Inhibits Porphyromonas gingivalis-induced Gingival Inflammation In Vivo and In Vitro. Zeng L, et al. Oral Health Prev Dent, 2022 Apr 27. PMID 35481344
    2. Mutations in the gene encoding c-Abl-binding protein SH3BP2 cause cherubism. Ueki Y, et al. Nat Genet, 2001 Jun. PMID 11381256
    3. Identification of a ten-amino acid proline-rich SH3 binding site. Ren R, et al. Science, 1993 Feb 19. PMID 8438166
    4. Tarp regulates early Chlamydia-induced host cell survival through interactions with the human adaptor protein SHC1. Mehlitz A, et al. J Cell Biol, 2010 Jul 12. PMID 20624904, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Overexpression of DEL-1 Downregulates SH3BP2 Expression and Inhibits Porphyromonas gingivalis-induced Gingival Inflammation In Vivo and In Vitro.
      Title: Overexpression of DEL-1 Downregulates SH3BP2 Expression and Inhibits Porphyromonas gingivalis-induced Gingival Inflammation In Vivo and In Vitro.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables SH3 domain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphotyrosine residue binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    SH3 domain-binding protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100684.1 → NP_001094154.1  SH3 domain-binding protein 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      BM384145, CB762696, CO557208, DY320365, EX490894, JAXUCZ010000014
      UniProtKB/TrEMBL
      A0A8I5ZMQ7, F1LS93
      Related
      ENSRNOP00000054918.2, ENSRNOT00000058111.3
      Conserved Domains (3) summary
      cd10359
      Location:486 → 586
      SH2_SH3BP2; Src homology 2 domain found in c-Abl SH3 domain-binding protein-2 (SH3BP2)
      cd13308
      Location:50 → 164
      PH_3BP2; SH3 domain-binding protein 2 Pleckstrin homology (PH) domain
      pfam00169
      Location:58 → 160
      PH; PH domain

    2. NM_001414976.1 → NP_001401905.1  SH3 domain-binding protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A0A8I5ZMQ7, A6IK29
      Related
      ENSRNOP00000079375.1, ENSRNOT00000105950.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      80400685..80437887 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039091976.2 → XP_038947904.1  SH3 domain-binding protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZMQ7, A6IK29
      Conserved Domains (2) summary
      cd10359
      Location:455 → 555
      SH2_SH3BP2; Src homology 2 domain found in c-Abl SH3 domain-binding protein-2 (SH3BP2)
      cd13308
      Location:19 → 133
      PH_3BP2; SH3 domain-binding protein 2 Pleckstrin homology (PH) domain

    2. XM_006251252.5 → XP_006251314.1  SH3 domain-binding protein 2 isoform X3

      See identical proteins and their annotated locations for XP_006251314.1

      UniProtKB/TrEMBL
      A0A8I5ZMQ7, A6IK29
      Conserved Domains (2) summary
      cd10359
      Location:455 → 555
      SH2_SH3BP2; Src homology 2 domain found in c-Abl SH3 domain-binding protein-2 (SH3BP2)
      cd13308
      Location:19 → 133
      PH_3BP2; SH3 domain-binding protein 2 Pleckstrin homology (PH) domain

    3. XM_006251253.5 → XP_006251315.1  SH3 domain-binding protein 2 isoform X3

      See identical proteins and their annotated locations for XP_006251315.1

      UniProtKB/TrEMBL
      A0A8I5ZMQ7, A6IK29
      Conserved Domains (2) summary
      cd10359
      Location:455 → 555
      SH2_SH3BP2; Src homology 2 domain found in c-Abl SH3 domain-binding protein-2 (SH3BP2)
      cd13308
      Location:19 → 133
      PH_3BP2; SH3 domain-binding protein 2 Pleckstrin homology (PH) domain

    4. XM_039091977.2 → XP_038947905.1  SH3 domain-binding protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZMQ7, A6IK29
      Conserved Domains (2) summary
      cd10359
      Location:455 → 555
      SH2_SH3BP2; Src homology 2 domain found in c-Abl SH3 domain-binding protein-2 (SH3BP2)
      cd13308
      Location:19 → 133
      PH_3BP2; SH3 domain-binding protein 2 Pleckstrin homology (PH) domain

    5. XM_006251248.5 → XP_006251310.1  SH3 domain-binding protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZMQ7, A0A8I6AKD3
      Related
      ENSRNOP00000093842.1
      Conserved Domains (3) summary
      cd10359
      Location:499 → 599
      SH2_SH3BP2; Src homology 2 domain found in c-Abl SH3 domain-binding protein-2 (SH3BP2)
      cd13308
      Location:63 → 177
      PH_3BP2; SH3 domain-binding protein 2 Pleckstrin homology (PH) domain
      pfam00169
      Location:71 → 173
      PH; PH domain

    6. XM_006251247.5 → XP_006251309.1  SH3 domain-binding protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZMQ7, A0A8I6A9V6
      Related
      ENSRNOP00000090587.1
      Conserved Domains (3) summary
      cd10359
      Location:511 → 611
      SH2_SH3BP2; Src homology 2 domain found in c-Abl SH3 domain-binding protein-2 (SH3BP2)
      cd13308
      Location:75 → 189
      PH_3BP2; SH3 domain-binding protein 2 Pleckstrin homology (PH) domain
      pfam00169
      Location:83 → 185
      PH; PH domain
    Nucleotide Protein Strain
    Heading Accession and Version

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