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    Nrg4 neuregulin 4 [ Mus musculus (house mouse) ]

    Gene ID: 83961, updated on 21-May-2024

    Summary

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    Official Symbol
    Nrg4provided by MGI
    Official Full Name
    neuregulin 4provided by MGI
    Primary source
    MGI:MGI:1933833
    See related
    Ensembl:ENSMUSG00000032311 AllianceGenome:MGI:1933833
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable signaling receptor binding activity. Predicted to be involved in animal organ development and intracellular signal transduction. Predicted to be located in extracellular region and plasma membrane. Predicted to be integral component of membrane. Predicted to be active in extracellular space. Is expressed in several structures, including connective tissue; embryo mesenchyme; integumental system; surface ectoderm; and uterus. Orthologous to human NRG4 (neuregulin 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in mammary gland adult (RPKM 13.4), subcutaneous fat pad adult (RPKM 12.2) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nrg4 in Genome Data Viewer
    Location:
    9 B; 9 29.87 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (55127506..55190937, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (55220222..55283654, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_24182 Neighboring gene STARR-seq mESC enhancer starr_24183 Neighboring gene STARR-seq mESC enhancer starr_24184 Neighboring gene STARR-seq mESC enhancer starr_24185 Neighboring gene karyopherin alpha 7 (importin alpha 8) pseudogene Neighboring gene ubiquitin-conjugating enzyme E2Q family member 2 Neighboring gene STARR-seq mESC enhancer starr_24186 Neighboring gene F-box protein 22 Neighboring gene STARR-positive B cell enhancer ABC_E9762 Neighboring gene serpine1 mRNA binding protein 1 pseudogene Neighboring gene transmembrane protein 266

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Brown adipose tissue-derived Nrg4 alleviates endothelial inflammation and atherosclerosis in male mice. Shi L, et al. Nat Metab, 2022 Nov. PMID 36400933, Free PMC Article
    2. Neuregulin-4 attenuates diabetic cardiomyopathy by regulating autophagy via the AMPK/mTOR signalling pathway. Wang H, et al. Cardiovasc Diabetol, 2022 Oct 11. PMID 36221104, Free PMC Article
    3. Neuregulin 4 Downregulation Induces Insulin Resistance in 3T3-L1 Adipocytes through Inflammation and Autophagic Degradation of GLUT4 Vesicles. Díaz-Sáez F, et al. Int J Mol Sci, 2021 Nov 30. PMID 34884763, Free PMC Article
    4. Neuregulin 4 Attenuates Osteoarthritis Progression by Inhibiting Inflammation and Apoptosis of Chondrocytes in Mice. Shi L, et al. Calcif Tissue Int, 2022 Jan. PMID 34383111
    5. Neuregulin-4 Is Required for Maintaining Soma Size of Pyramidal Neurons in the Motor Cortex. Paramo B, et al. eNeuro, 2021 Jan-Feb. PMID 33495243, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Neuregulin 4 mediates the metabolic benefits of mild cold exposure by promoting beige fat thermogenesis.
      Title: Neuregulin 4 mediates the metabolic benefits of mild cold exposure by promoting beige fat thermogenesis.
    2. Deletion of Endogenous Neuregulin-4 Limits Adaptive Immunity During Interleukin-10 Receptor-Neutralizing Colitis.
      Title: Deletion of Endogenous Neuregulin-4 Limits Adaptive Immunity During Interleukin-10 Receptor-Neutralizing Colitis.
    3. Neuregulin4 Acts on Hypothalamic ErBb4 to Excite Oxytocin Neurons and Preserve Metabolic Homeostasis.
      Title: Neuregulin4 Acts on Hypothalamic ErBb4 to Excite Oxytocin Neurons and Preserve Metabolic Homeostasis.
    4. Brown adipose tissue-derived Nrg4 alleviates endothelial inflammation and atherosclerosis in male mice.
      Title: Brown adipose tissue-derived Nrg4 alleviates endothelial inflammation and atherosclerosis in male mice.
    5. Neuregulin-4 attenuates diabetic cardiomyopathy by regulating autophagy via the AMPK/mTOR signalling pathway.
      Title: Neuregulin-4 attenuates diabetic cardiomyopathy by regulating autophagy via the AMPK/mTOR signalling pathway.
    6. Neuregulin 4 suppresses NASH-HCC development by restraining tumor-prone liver microenvironment.
      Title: Neuregulin 4 suppresses NASH-HCC development by restraining tumor-prone liver microenvironment.
    7. Neuregulin 4 Attenuates Osteoarthritis Progression by Inhibiting Inflammation and Apoptosis of Chondrocytes in Mice.
      Title: Neuregulin 4 Attenuates Osteoarthritis Progression by Inhibiting Inflammation and Apoptosis of Chondrocytes in Mice.
    8. Neuregulin 4 Downregulation Induces Insulin Resistance in 3T3-L1 Adipocytes through Inflammation and Autophagic Degradation of GLUT4 Vesicles.
      Title: Neuregulin 4 Downregulation Induces Insulin Resistance in 3T3-L1 Adipocytes through Inflammation and Autophagic Degradation of GLUT4 Vesicles.
    9. Neuregulin-4 Is Required for Maintaining Soma Size of Pyramidal Neurons in the Motor Cortex.
      Title: Neuregulin-4 Is Required for Maintaining Soma Size of Pyramidal Neurons in the Motor Cortex.
    10. hepatic Nrg4 signaling serves as an endocrine checkpoint for steatosis-to-NASH progression by activating a cytoprotective pathway to counter stress-induced liver injury.
      Title: Hepatic neuregulin 4 signaling defines an endocrine checkpoint for steatosis-to-NASH progression.
    Submit: New GeneRIF Correction See all GeneRIFs (16)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 
    • Targeted (3)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables receptor ligand activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables receptor ligand activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables signaling receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERBB4-ERBB4 signaling pathway IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    pro-neuregulin-4, membrane-bound isoform
    Names
    pro-NRG4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001425100.1 → NP_001412029.1  pro-neuregulin-4, membrane-bound isoform isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC157328

    2. NM_032002.3 → NP_114391.1  pro-neuregulin-4, membrane-bound isoform isoform 2

      See identical proteins and their annotated locations for NP_114391.1

      Status: VALIDATED

      Source sequence(s)
      AC157328
      Consensus CDS
      CCDS52801.1
      UniProtKB/Swiss-Prot
      Q9WTX4
      Related
      ENSMUSP00000130929.2, ENSMUST00000164721.8
      Conserved Domains (1) summary
      PHA03099
      Location:9 → 84
      PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional

    RNA

    1. NR_189137.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC157328
      Related
      ENSMUST00000139261.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      55127506..55190937 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017313706.3 → XP_017169195.1  pro-neuregulin-4, membrane-bound isoform isoform X1

      UniProtKB/Swiss-Prot
      Q9WTX4
      Related
      ENSMUSP00000115247.2, ENSMUST00000130158.8
      Conserved Domains (1) summary
      PHA03099
      Location:9 → 84
      PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional

    2. XM_017313705.3 → XP_017169194.1  pro-neuregulin-4, membrane-bound isoform isoform X1

      UniProtKB/Swiss-Prot
      Q9WTX4
      Conserved Domains (1) summary
      PHA03099
      Location:9 → 84
      PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional

    3. XM_017313704.2 → XP_017169193.1  pro-neuregulin-4, membrane-bound isoform isoform X1

      UniProtKB/Swiss-Prot
      Q9WTX4
      Conserved Domains (1) summary
      PHA03099
      Location:9 → 84
      PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WTX4.1 GenPept UniProtKB/Swiss-Prot:Q9WTX4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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