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    Hbb-bh2 hemoglobin beta, bh2 [ Mus musculus (house mouse) ]

    Gene ID: 436003, updated on 9-May-2024

    Summary

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    Official Symbol
    Hbb-bh2provided by MGI
    Official Full Name
    hemoglobin beta, bh2provided by MGI
    Primary source
    MGI:MGI:96025
    See related
    Ensembl:ENSMUSG00000078621 AllianceGenome:MGI:96025
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm5736; EG436003
    Summary
    Predicted to enable several functions, including heme binding activity; hemoglobin binding activity; and oxygen carrier activity. Predicted to contribute to haptoglobin binding activity and peroxidase activity. Predicted to be involved in glutathione metabolic process; hydrogen peroxide catabolic process; and oxygen transport. Predicted to be located in extracellular space. Predicted to be part of haptoglobin-hemoglobin complex and hemoglobin complex. Is expressed in embryo; heart; liver; spleen; and testis. Human ortholog(s) of this gene implicated in acute chest syndrome; hemolytic anemia (multiple); malaria; polycythemia (multiple); and sickle cell anemia. Orthologous to human HBB (hemoglobin subunit beta) and HBD (hemoglobin subunit delta). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Hbb-bh2 in Genome Data Viewer
    Location:
    7 54.85 cM; 7 E3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (103488008..103490418, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (103838801..103840734, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene 15115 Neighboring gene hemoglobin beta, pseudogene bh3 Neighboring gene hemoglobin Z, beta-like embryonic chain Neighboring gene beta-globin HS-E1 embryonic enhancer Neighboring gene hemoglobin Y, beta-like embryonic chain Neighboring gene hemoglobin, activating region

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The complete nucleotide sequence of a beta-globin-like structure, beta h2, from the [Hbb]d mouse BALB/c. Phillips SJ, et al. J Biol Chem, 1984 Jun 25. PMID 6736028
    2. Extensive movement of LINES ONE sequences in beta-globin loci of Mus caroli and Mus domesticus. Casavant NC, et al. Mol Cell Biol, 1988 Nov. PMID 2905421, Free PMC Article
    3. The mouse globin pseudogene beta h3 is descended from a premammalian delta-globin gene. Hutchison CA 3rd, et al. J Biol Chem, 1984 Oct 25. PMID 6092350
    4. A naturally occurring deletion in the mouse Hbbs beta-globin gene cluster. Holdener-Kenny B, et al. Proc Natl Acad Sci U S A, 1986 Jun. PMID 3459181, Free PMC Article
    5. DNA sequence organization of the beta-globin complex in the BALB/c mouse. Jahn CL, et al. Cell, 1980 Aug. PMID 6250710

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to haptoglobin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to haptoglobin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables heme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hemoglobin alpha binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hemoglobin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables organic acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxygen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxygen binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxygen carrier activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to peroxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to peroxidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in hydrogen peroxide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of haptoglobin-hemoglobin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of haptoglobin-hemoglobin complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of hemoglobin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of hemoglobin complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    hemoglobin beta, bh2
    Names
    hemoglobin beta, pseudogene bh2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127686.1 → NP_001121158.1  hemoglobin beta, bh2

      See identical proteins and their annotated locations for NP_001121158.1

      Status: PROVISIONAL

      Source sequence(s)
      BC147125
      Consensus CDS
      CCDS52340.1
      UniProtKB/TrEMBL
      B2RVB7
      Related
      ENSMUSP00000102479.2, ENSMUST00000106866.3
      Conserved Domains (1) summary
      cd08925
      Location:7 → 133
      Hb-beta_like; Hemoglobin beta, gamma, delta, epsilon, and related Hb subunits

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      103488008..103490418 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006508005.4 → XP_006508068.1  hemoglobin beta, bh2 isoform X1

      Conserved Domains (1) summary
      cl21461
      Location:8 → 105
      Globin-like; Globin-like protein superfamily

    RNA

    1. XR_378259.4 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NG_027834.1: Suppressed sequence

      Description
      NG_027834.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.

    2. NG_027843.1: Suppressed sequence

      Description
      NG_027843.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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