Stab1 stabilin 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Stab1provided by MGI
Official Full Name: stabilin 1provided by MGI
Primary source: MGI:MGI:2178742
See related: Ensembl:ENSMUSG00000042286 AllianceGenome:MGI:2178742
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MS-1; FEEL-1; FELE-1; STAB-1; MFEEL-1; mKIAA0246
Summary: Predicted to enable low-density lipoprotein particle binding activity; low-density lipoprotein particle receptor activity; and scavenger receptor activity. Predicted to be involved in cell-cell signaling; defense response to bacterium; and negative regulation of angiogenesis. Predicted to act upstream of or within inflammatory response. Predicted to be located in cytoplasm. Predicted to be integral component of plasma membrane. Is expressed in several structures, including cardiovascular system; extraembryonic component; genitourinary system; lung epithelium; and retina nuclear layer. Orthologous to human STAB1 (stabilin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in ovary adult (RPKM 36.3), subcutaneous fat pad adult (RPKM 27.9) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 B; 14 19.09 cM

Exon count:: 69

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (30860974..30890616, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (31139017..31168651, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deficiency for scavenger receptors Stabilin-1 and Stabilin-2 leads to age-dependent renal and hepatic depositions of fasciclin domain proteins TGFBI and Periostin in mice.
Title: Deficiency for scavenger receptors Stabilin-1 and Stabilin-2 leads to age-dependent renal and hepatic depositions of fasciclin domain proteins TGFBI and Periostin in mice.
Stabilin-1 plays a protective role against Listeria monocytogenes infection through the regulation of cytokine and chemokine production and immune cell recruitment.
Title: Stabilin-1 plays a protective role against Listeria monocytogenes infection through the regulation of cytokine and chemokine production and immune cell recruitment.
Lymphatic Endothelial Cell Activation and Dendritic Cell Transmigration Is Modified by Genetic Deletion of Clever-1.
Title: Lymphatic Endothelial Cell Activation and Dendritic Cell Transmigration Is Modified by Genetic Deletion of Clever-1.
New tools to prevent cancer growth and spread: a 'Clever' approach.
Title: New tools to prevent cancer growth and spread: a 'Clever' approach.
Identifying Stabilin-1 and Stabilin-2 Double Knockouts in Reproduction and Placentation: A Descriptive Study.
Title: Identifying Stabilin-1 and Stabilin-2 Double Knockouts in Reproduction and Placentation: A Descriptive Study.
Exploring the transcriptomic network of multi-ligand scavenger receptor Stabilin-1- and Stabilin-2-deficient liver sinusoidal endothelial cells.
Title: Exploring the transcriptomic network of multi-ligand scavenger receptor Stabilin-1- and Stabilin-2-deficient liver sinusoidal endothelial cells.
Ablation of Stabilin-1 Enhances Bone-Resorbing Activity in Osteoclasts In Vitro.
Title: Ablation of Stabilin-1 Enhances Bone-Resorbing Activity in Osteoclasts In Vitro.
Bone marrow-specific Stabilin-1 deletion does not affect the susceptibility for atherosclerosis in Ldl receptor knockout mice.
Title: Hematopoietic Stabilin-1 deficiency does not influence atherosclerosis susceptibility in LDL receptor knockout mice.
Data show that the excessive inflammatory activity of monocytes/macrophages in the absence of Clever-1/Stabilin-1 results in augmented humoral immune responses in vivo.
Title: Enhanced Antibody Production in Clever-1/Stabilin-1-Deficient Mice.
these findings indicated that STAB-1 regulated and maintained vascular integrity through the clearance of infected apoptotic endothelial cells
Title: Macrophagic Stabilin-1 Restored Disruption of Vascular Integrity Caused by Sepsis.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables hyaluronic acid binding	IEA Inferred from Electronic Annotation more info
enables low-density lipoprotein particle binding	ISO Inferred from Sequence Orthology more info
enables low-density lipoprotein particle receptor activity	ISO Inferred from Sequence Orthology more info
enables scavenger receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell-cell signaling	ISO Inferred from Sequence Orthology more info
involved_in defense response to bacterium	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of angiogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: stabilin-1

Names: fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 1; scavenger receptor FEEL-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_138672.2 → NP_619613.2 stabilin-1 precursor

See identical proteins and their annotated locations for NP_619613.2

Status: VALIDATED

Source sequence(s)

AC154446

Consensus CDS

CCDS26906.1

UniProtKB/TrEMBL

E5RKB6, G3X973

Related

ENSMUSP00000046199.8, ENSMUST00000036618.14

Conserved Domains (5) summary

smart00180
Location:1992 → 2021

EGF_Lam; Laminin-type epidermal growth factor-like domai

smart00554
Location:2367 → 2463

FAS1; Four repeated domains in the Fasciclin I family of proteins, present in many other contexts

pfam02469
Location:1737 → 1867

Fasciclin; Fasciclin domain

pfam12947
Location:1460 → 1496

EGF_3; EGF domain

cl02612
Location:2208 → 2300

Link_Domain; The link domain is a hyaluronan (HA)-binding domain. It functions to mediate adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It is found in the CD44 receptor and in human TSG-6. TSG-6 is the protein product of the tumor ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

30860974..30890616 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036158521.1 → XP_036014414.1 stabilin-1 isoform X1

UniProtKB/TrEMBL

E5RKB6

Conserved Domains (7) summary

smart00180
Location:1991 → 2020

EGF_Lam; Laminin-type epidermal growth factor-like domai

smart00554
Location:2366 → 2462

FAS1; Four repeated domains in the Fasciclin I family of proteins, present in many other contexts

pfam02469
Location:1737 → 1867

Fasciclin; Fasciclin domain

pfam12947
Location:1460 → 1496

EGF_3; EGF domain

NF033759
Location:107 → 356

exchanger_TraA; outer membrane exchange protein TraA

cl02612
Location:2207 → 2299

Link_Domain; The link domain is a hyaluronan (HA)-binding domain. It functions to mediate adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It is found in the CD44 receptor and in human TSG-6. TSG-6 is the protein product of the tumor ...

cl21504
Location:831 → 860

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
XM_036158522.1 → XP_036014415.1 stabilin-1 isoform X2

UniProtKB/TrEMBL

E5RKB6

Conserved Domains (5) summary

smart00180
Location:1992 → 2021

EGF_Lam; Laminin-type epidermal growth factor-like domai

pfam02469
Location:1737 → 1867

Fasciclin; Fasciclin domain

pfam12947
Location:1460 → 1496

EGF_3; EGF domain

cl02612
Location:2208 → 2300

Link_Domain; The link domain is a hyaluronan (HA)-binding domain. It functions to mediate adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It is found in the CD44 receptor and in human TSG-6. TSG-6 is the protein product of the tumor ...

cl21504
Location:831 → 860

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
XM_036158523.1 → XP_036014416.1 stabilin-1 isoform X3

Conserved Domains (3) summary

pfam02469
Location:520 → 644

Fasciclin; Fasciclin domain

pfam12947
Location:1460 → 1496

EGF_3; EGF domain

cl21504
Location:831 → 860

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...