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    Man2a2 mannosidase, alpha, class 2A, member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308757, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Man2a2provided by RGD
    Official Full Name
    mannosidase, alpha, class 2A, member 2provided by RGD
    Primary source
    RGD:1310238
    See related
    Ensembl:ENSRNOG00000012055 AllianceGenome:RGD:1310238
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable alpha-mannosidase activity and hydrolase activity, hydrolyzing N-glycosyl compounds. Predicted to be involved in N-glycan processing and protein deglycosylation. Predicted to be integral component of membrane. Predicted to be active in Golgi membrane. Orthologous to human MAN2A2 (mannosidase alpha class 2A member 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Muscle (RPKM 153.8), Testes (RPKM 151.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Man2a2 in Genome Data Viewer
    Location:
    1q31
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (143712157..143736624, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (134304714..134327611, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (142141695..142164561, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene shisa like 3 Neighboring gene HD domain containing 3 Neighboring gene ribosomal protein L35A like 7 Neighboring gene FES proto-oncogene, tyrosine kinase Neighboring gene uncharacterized LOC102553801 Neighboring gene furin (paired basic amino acid cleaving enzyme)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Essential and mutually compensatory roles of {alpha}-mannosidase II and {alpha}-mannosidase IIx in N-glycan processing in vivo in mice. Akama TO, et al. Proc Natl Acad Sci U S A, 2006 Jun 13. PMID 16754854, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables alpha-mannosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, hydrolyzing N-glycosyl compounds ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mannosidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-glycan processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mannose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein deglycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    alpha-mannosidase 2x
    Names
    mannosidase 2, alpha 2
    NP_001100997.1
    XP_008757749.1
    XP_008757751.1
    XP_008757752.1
    XP_017444654.1
    XP_063118711.1
    XP_063118712.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107527.1 → NP_001100997.1  alpha-mannosidase 2x

      See identical proteins and their annotated locations for NP_001100997.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473980
      UniProtKB/TrEMBL
      A0A0G2JWG1, A6JCB0
      Conserved Domains (4) summary
      PLN02701
      Location:140 → 1163
      PLN02701; alpha-mannosidase
      smart00872
      Location:503 → 588
      Alpha-mann_mid; Alpha mannosidase, middle domain
      pfam07748
      Location:761 → 1159
      Glyco_hydro_38C; Glycosyl hydrolases family 38 C-terminal domain
      cl15692
      Location:165 → 508
      CE4_SF; Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      143712157..143736624 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063262641.1 → XP_063118711.1  alpha-mannosidase 2x isoform X2

    2. XM_008759529.4 → XP_008757751.1  alpha-mannosidase 2x isoform X1

      See identical proteins and their annotated locations for XP_008757751.1

      UniProtKB/TrEMBL
      A0A0G2JWG1
      Conserved Domains (4) summary
      PLN02701
      Location:140 → 1174
      PLN02701; alpha-mannosidase
      smart00872
      Location:503 → 588
      Alpha-mann_mid; Alpha mannosidase, middle domain
      pfam07748
      Location:761 → 1170
      Glyco_hydro_38C; Glycosyl hydrolases family 38 C-terminal domain
      cl15692
      Location:165 → 508
      CE4_SF; Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily

    3. XM_008759530.4 → XP_008757752.1  alpha-mannosidase 2x isoform X2

      UniProtKB/TrEMBL
      A0A0G2JWG1
      Related
      ENSRNOP00000016281.8
      Conserved Domains (4) summary
      PLN02701
      Location:140 → 1149
      PLN02701; alpha-mannosidase
      smart00872
      Location:503 → 588
      Alpha-mann_mid; Alpha mannosidase, middle domain
      pfam07748
      Location:761 → 1145
      Glyco_hydro_38C; Glycosyl hydrolases family 38 C-terminal domain
      cl15692
      Location:165 → 508
      CE4_SF; Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily

    4. XM_008759527.4 → XP_008757749.1  alpha-mannosidase 2x isoform X1

      See identical proteins and their annotated locations for XP_008757749.1

      UniProtKB/TrEMBL
      A0A0G2JWG1
      Conserved Domains (4) summary
      PLN02701
      Location:140 → 1174
      PLN02701; alpha-mannosidase
      smart00872
      Location:503 → 588
      Alpha-mann_mid; Alpha mannosidase, middle domain
      pfam07748
      Location:761 → 1170
      Glyco_hydro_38C; Glycosyl hydrolases family 38 C-terminal domain
      cl15692
      Location:165 → 508
      CE4_SF; Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily

    5. XM_017589165.3 → XP_017444654.1  alpha-mannosidase 2x isoform X1

      UniProtKB/TrEMBL
      A0A0G2JWG1
      Related
      ENSRNOP00000069866.2
      Conserved Domains (4) summary
      PLN02701
      Location:140 → 1174
      PLN02701; alpha-mannosidase
      smart00872
      Location:503 → 588
      Alpha-mann_mid; Alpha mannosidase, middle domain
      pfam07748
      Location:761 → 1170
      Glyco_hydro_38C; Glycosyl hydrolases family 38 C-terminal domain
      cl15692
      Location:165 → 508
      CE4_SF; Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily

    6. XM_063262642.1 → XP_063118712.1  alpha-mannosidase 2x isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

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