Cr2 complement C3d receptor 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cr2provided by RGD
Official Full Name: complement C3d receptor 2provided by RGD
Primary source: RGD:1310065
See related: Ensembl:ENSRNOG00000034164 AllianceGenome:RGD:1310065
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cd21
Summary: Predicted to enable several functions, including complement binding activity; complement receptor activity; and protein homodimerization activity. Predicted to be involved in B cell differentiation; B cell proliferation; and negative regulation of complement activation, classical pathway. Predicted to act upstream of or within with a negative effect on complement activation, alternative pathway. Predicted to act upstream of or within several processes, including cellular response to lipopolysaccharide; immunoglobulin mediated immune response; and skeletal system development. Located in several cellular components, including cell surface; extracellular space; and nucleus. Human ortholog(s) of this gene implicated in common variable immunodeficiency; nasopharynx carcinoma; and systemic lupus erythematosus. Orthologous to human CR2 (complement C3d receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 1089.6) See more
Orthologs: human mouse all
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Genomic context

Location:: 13q27

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (109207034..109244980, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (106678579..106716595, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (113890274..113927824, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phthalide derivative CD21 regulates the platelet- neutrophil extracellular trap-thrombin axis and protects against ischemic brain injury in rodents.
Title: Phthalide derivative CD21 regulates the platelet- neutrophil extracellular trap-thrombin axis and protects against ischemic brain injury in rodents.
CD21 is expressed in the rat mucosal mast cell line RBL-2H3
Title: Mucosal type mast cells express complement receptor type 2 (CD21).

Submit: New GeneRIF Correction

General gene information

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Markers

AI029543 (e-PCR)
- UniSTS:246047

AI177829 (e-PCR)
- UniSTS:250468

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables complement binding	ISO Inferred from Sequence Orthology more info
enables complement receptor activity	ISO Inferred from Sequence Orthology more info
enables immunoglobulin receptor binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in B cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in B cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in T cell mediated immunity	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within bone development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cartilage development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within_negative_effect complement activation, alternative pathway	ISO Inferred from Sequence Orthology more info
involved_in complement activation, alternative pathway	ISO Inferred from Sequence Orthology more info
involved_in complement receptor mediated signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within immunoglobulin mediated immune response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of complement activation, classical pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: complement receptor type 2

Names: complement component (3d/Epstein Barr virus) receptor 2; complement component 3d receptor 2; complement receptor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001105989.2 → NP_001099459.2 complement receptor type 2 precursor

See identical proteins and their annotated locations for NP_001099459.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/TrEMBL

A6JH50

Conserved Domains (2) summary

cd00033
Location:719 → 775

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

PHA02927
Location:711 → 964

PHA02927; secreted complement-binding protein; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

109207034..109244980 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008769847.4 → XP_008768069.1 complement receptor type 2 isoform X1

UniProtKB/TrEMBL

D3Z9F7

Related

ENSRNOP00000010910.7

Conserved Domains (4) summary

cd00033
Location:1096 → 1152

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

smart00032
Location:83 → 140

CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)

PHA02927
Location:10 → 274

PHA02927; secreted complement-binding protein; Provisional

pfam00084
Location:337 → 395

Sushi; Sushi repeat (SCR repeat)
XM_063272195.1 → XP_063128265.1 complement receptor type 2 isoform X2