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    Arhgap10 Rho GTPase activating protein 10 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 688429, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Arhgap10provided by RGD
    Official Full Name
    Rho GTPase activating protein 10provided by RGD
    Primary source
    RGD:1588859
    See related
    Ensembl:ENSRNOG00000013152 AllianceGenome:RGD:1588859
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in cytoskeleton organization and negative regulation of apoptotic process. Predicted to be active in cytosol. Orthologous to human ARHGAP10 (Rho GTPase activating protein 10). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 66.0), Heart (RPKM 58.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Arhgap10 in Genome Data Viewer
    Location:
    19q11
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (47352783..47614532)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (30448572..30710315)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (34138978..34406593)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483343 Neighboring gene endothelin receptor type A Neighboring gene transmembrane protein 184C Neighboring gene protein arginine methyltransferase 9 Neighboring gene uncharacterized LOC134483344 Neighboring gene membrane-associated progesterone receptor component 1 pseudogene Neighboring gene uncharacterized LOC134483345 Neighboring gene nuclear receptor subfamily 3, group C, member 2 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC134483346

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of PS-GAP as a novel regulator of caspase-activated PAK-2. Koeppel MA, et al. J Biol Chem, 2004 Dec 17. PMID 15471851
    2. Regulation of CDC42 GTPase by proline-rich tyrosine kinase 2 interacting with PSGAP, a novel pleckstrin homology and Src homology 3 domain containing rhoGAP protein. Ren XR, et al. J Cell Biol, 2001 Mar 5. PMID 11238453, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    rho GTPase-activating protein 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109501.1 → NP_001102971.1  rho GTPase-activating protein 10

      See identical proteins and their annotated locations for NP_001102971.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473972
      UniProtKB/TrEMBL
      A6IYL0, D4AB50
      Related
      ENSRNOP00000017867.6, ENSRNOT00000017867.6
      Conserved Domains (5) summary
      cd07635
      Location:19 → 225
      BAR_GRAF2; The Bin/Amphiphysin/Rvs (BAR) domain of GTPase Regulator Associated with Focal adhesion 2
      cd12065
      Location:732 → 785
      SH3_GRAF2; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase 2
      cd04374
      Location:367 → 569
      RhoGAP_Graf; RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences ...
      cd01249
      Location:267 → 372
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
      pfam00169
      Location:269 → 367
      PH; PH domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      47352783..47614532
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039097993.2 → XP_038953921.1  rho GTPase-activating protein 10 isoform X9

      Conserved Domains (2) summary
      cd01249
      Location:267 → 366
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
      cl12013
      Location:19 → 225
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    2. XM_039097995.2 → XP_038953923.1  rho GTPase-activating protein 10 isoform X10

      Conserved Domains (2) summary
      cd01249
      Location:267 → 366
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
      cl12013
      Location:19 → 225
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    3. XM_017601359.3 → XP_017456848.1  rho GTPase-activating protein 10 isoform X6

    4. XM_039097987.2 → XP_038953915.1  rho GTPase-activating protein 10 isoform X2

      UniProtKB/TrEMBL
      A0A8I6ADP2
      Related
      ENSRNOP00000076625.1
      Conserved Domains (5) summary
      cd07635
      Location:19 → 225
      BAR_GRAF2; The Bin/Amphiphysin/Rvs (BAR) domain of GTPase Regulator Associated with Focal adhesion 2
      cd12065
      Location:744 → 797
      SH3_GRAF2; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase 2
      PHA03247
      Location:554 → 691
      PHA03247; large tegument protein UL36; Provisional
      cd01249
      Location:267 → 372
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
      cl02570
      Location:367 → 544
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

    5. XM_039097986.2 → XP_038953914.1  rho GTPase-activating protein 10 isoform X1

      UniProtKB/TrEMBL
      D4AB50
      Conserved Domains (5) summary
      cd07635
      Location:19 → 225
      BAR_GRAF2; The Bin/Amphiphysin/Rvs (BAR) domain of GTPase Regulator Associated with Focal adhesion 2
      cd12065
      Location:769 → 822
      SH3_GRAF2; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase 2
      PHA03247
      Location:579 → 716
      PHA03247; large tegument protein UL36; Provisional
      cd04374
      Location:367 → 569
      RhoGAP_Graf; GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal ...
      cd01249
      Location:267 → 372
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain

    6. XM_008772531.4 → XP_008770753.1  rho GTPase-activating protein 10 isoform X4

      UniProtKB/TrEMBL
      A0A8I6A8K7, D4AB50
      Related
      ENSRNOP00000089391.1
      Conserved Domains (5) summary
      cd12065
      Location:681 → 734
      SH3_GRAF2; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase 2
      cd04374
      Location:367 → 569
      RhoGAP_Graf; RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences ...
      cd01249
      Location:267 → 372
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
      pfam00169
      Location:269 → 367
      PH; PH domain
      cl12013
      Location:19 → 225
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    7. XM_063278285.1 → XP_063134355.1  rho GTPase-activating protein 10 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZK44

    8. XM_039097988.2 → XP_038953916.1  rho GTPase-activating protein 10 isoform X5

      UniProtKB/TrEMBL
      D4AB50
      Conserved Domains (5) summary
      cd12065
      Location:666 → 719
      SH3_GRAF2; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase 2
      PHA03247
      Location:476 → 613
      PHA03247; large tegument protein UL36; Provisional
      cd04374
      Location:264 → 466
      RhoGAP_Graf; GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal ...
      cd01249
      Location:164 → 269
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
      cl12013
      Location:1 → 122
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    9. XM_063278286.1 → XP_063134356.1  rho GTPase-activating protein 10 isoform X5

    10. XM_039097992.1 → XP_038953920.1  rho GTPase-activating protein 10 isoform X5

      UniProtKB/TrEMBL
      D4AB50
      Conserved Domains (5) summary
      cd12065
      Location:666 → 719
      SH3_GRAF2; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase 2
      PHA03247
      Location:476 → 613
      PHA03247; large tegument protein UL36; Provisional
      cd04374
      Location:264 → 466
      RhoGAP_Graf; GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal ...
      cd01249
      Location:164 → 269
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
      cl12013
      Location:1 → 122
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    11. XM_063278287.1 → XP_063134357.1  rho GTPase-activating protein 10 isoform X7

    12. XM_063278288.1 → XP_063134358.1  rho GTPase-activating protein 10 isoform X8

    13. XM_039097989.2 → XP_038953917.1  rho GTPase-activating protein 10 isoform X5

      UniProtKB/TrEMBL
      D4AB50
      Conserved Domains (5) summary
      cd12065
      Location:666 → 719
      SH3_GRAF2; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase 2
      PHA03247
      Location:476 → 613
      PHA03247; large tegument protein UL36; Provisional
      cd04374
      Location:264 → 466
      RhoGAP_Graf; GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal ...
      cd01249
      Location:164 → 269
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
      cl12013
      Location:1 → 122
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    14. XM_039097991.2 → XP_038953919.1  rho GTPase-activating protein 10 isoform X5

      UniProtKB/TrEMBL
      D4AB50
      Conserved Domains (5) summary
      cd12065
      Location:666 → 719
      SH3_GRAF2; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase 2
      PHA03247
      Location:476 → 613
      PHA03247; large tegument protein UL36; Provisional
      cd04374
      Location:264 → 466
      RhoGAP_Graf; GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal ...
      cd01249
      Location:164 → 269
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
      cl12013
      Location:1 → 122
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    15. XM_039097990.2 → XP_038953918.1  rho GTPase-activating protein 10 isoform X5

      UniProtKB/TrEMBL
      D4AB50
      Conserved Domains (5) summary
      cd12065
      Location:666 → 719
      SH3_GRAF2; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase 2
      PHA03247
      Location:476 → 613
      PHA03247; large tegument protein UL36; Provisional
      cd04374
      Location:264 → 466
      RhoGAP_Graf; GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal ...
      cd01249
      Location:164 → 269
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
      cl12013
      Location:1 → 122
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    RNA

    1. XR_005496688.2 RNA Sequence

    2. XR_010060031.1 RNA Sequence

    3. XR_005496687.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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