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    Rcbtb2 RCC1 and BTB domain containing protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 290363, updated on 2-May-2024

    Summary

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    Official Symbol
    Rcbtb2provided by RGD
    Official Full Name
    RCC1 and BTB domain containing protein 2provided by RGD
    Primary source
    RGD:735048
    See related
    Ensembl:ENSRNOG00000015054 AllianceGenome:RGD:735048
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Chc1l
    Summary
    Predicted to be located in acrosomal vesicle. Predicted to be active in cytoplasm. Orthologous to human RCBTB2 (RCC1 and BTB domain containing protein 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Liver (RPKM 233.9), Spleen (RPKM 120.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rcbtb2 in Genome Data Viewer
    Location:
    15q11
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (54729367..54774004)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (48319809..48364441)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (55029388..55074728)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L40, pseudogene 2 Neighboring gene uncharacterized LOC134482149 Neighboring gene uncharacterized LOC120097036 Neighboring gene uncharacterized LOC134482150 Neighboring gene RB transcriptional corepressor 1 Neighboring gene lysophosphatidic acid receptor 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mouse RC/BTB2, a member of the RCC1 superfamily, localizes to spermatid acrosomal vesicles. Wang J, et al. PLoS One, 2012. PMID 22768142, Free PMC Article
    2. cDNA cloning, gene characterization and 13q14.3 chromosomal assignment of CHC1-L, a chromosome condensation regulator-like guanine nucleotide exchange factor. Devilder MC, et al. Genomics, 1998 Nov 15. PMID 9806834
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC72635

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within digestive tract development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within liver development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within lymph node development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within spleen development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in acrosomal vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RCC1 and BTB domain-containing protein 2
    Names
    regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
    regulator of chromosome condensation and BTB domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199084.1 → NP_954515.1  RCC1 and BTB domain-containing protein 2

      See identical proteins and their annotated locations for NP_954515.1

      Status: PROVISIONAL

      Source sequence(s)
      BC061766
      UniProtKB/Swiss-Prot
      Q6P798
      UniProtKB/TrEMBL
      A0A8L2R3I1, A6HTQ0
      Related
      ENSRNOP00000020836.4, ENSRNOT00000020836.7
      Conserved Domains (3) summary
      COG5184
      Location:107 → 387
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd18354
      Location:374 → 490
      BTB_POZ_RCBTB2_CHC1L; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)
      cd18529
      Location:487 → 551
      BACK_RCBTB2; BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      54729367..54774004
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063274145.1 → XP_063130215.1  RCC1 and BTB domain-containing protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q6P798
      UniProtKB/TrEMBL
      A6HTQ0

    2. XM_039093171.2 → XP_038949099.1  RCC1 and BTB domain-containing protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A8L2R3I1
      Conserved Domains (3) summary
      COG5184
      Location:83 → 363
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd18354
      Location:350 → 466
      BTB_POZ_RCBTB2_CHC1L; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)
      cd18529
      Location:463 → 527
      BACK_RCBTB2; BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)

    3. XM_063274146.1 → XP_063130216.1  RCC1 and BTB domain-containing protein 2 isoform X2

    4. XM_063274147.1 → XP_063130217.1  RCC1 and BTB domain-containing protein 2 isoform X2

    5. XM_008770845.4 → XP_008769067.1  RCC1 and BTB domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_008769067.1

      UniProtKB/Swiss-Prot
      Q6P798
      UniProtKB/TrEMBL
      A0A8L2R3I1, A6HTQ0
      Conserved Domains (3) summary
      COG5184
      Location:107 → 387
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd18354
      Location:374 → 490
      BTB_POZ_RCBTB2_CHC1L; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)
      cd18529
      Location:487 → 551
      BACK_RCBTB2; BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)

    6. XM_063274148.1 → XP_063130218.1  RCC1 and BTB domain-containing protein 2 isoform X2

    7. XM_008770858.4 → XP_008769080.1  RCC1 and BTB domain-containing protein 2 isoform X2

      See identical proteins and their annotated locations for XP_008769080.1

      UniProtKB/TrEMBL
      A0A8L2R3I1
      Conserved Domains (3) summary
      COG5184
      Location:83 → 363
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd18354
      Location:350 → 466
      BTB_POZ_RCBTB2_CHC1L; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)
      cd18529
      Location:463 → 527
      BACK_RCBTB2; BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)

    8. XM_039093165.2 → XP_038949093.1  RCC1 and BTB domain-containing protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q6P798
      UniProtKB/TrEMBL
      A0A8L2R3I1, A6HTQ0
      Conserved Domains (3) summary
      COG5184
      Location:107 → 387
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd18354
      Location:374 → 490
      BTB_POZ_RCBTB2_CHC1L; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)
      cd18529
      Location:487 → 551
      BACK_RCBTB2; BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)

    9. XM_008770846.4 → XP_008769068.1  RCC1 and BTB domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_008769068.1

      UniProtKB/Swiss-Prot
      Q6P798
      UniProtKB/TrEMBL
      A0A8L2R3I1, A6HTQ0
      Conserved Domains (3) summary
      COG5184
      Location:107 → 387
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd18354
      Location:374 → 490
      BTB_POZ_RCBTB2_CHC1L; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)
      cd18529
      Location:487 → 551
      BACK_RCBTB2; BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)

    10. XM_039093172.2 → XP_038949100.1  RCC1 and BTB domain-containing protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A8L2R3I1
      Conserved Domains (3) summary
      COG5184
      Location:83 → 363
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd18354
      Location:350 → 466
      BTB_POZ_RCBTB2_CHC1L; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)
      cd18529
      Location:463 → 527
      BACK_RCBTB2; BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)

    11. XM_063274150.1 → XP_063130220.1  RCC1 and BTB domain-containing protein 2 isoform X2

    12. XM_063274144.1 → XP_063130214.1  RCC1 and BTB domain-containing protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q6P798
      UniProtKB/TrEMBL
      A6HTQ0

    13. XM_008770861.4 → XP_008769083.1  RCC1 and BTB domain-containing protein 2 isoform X2

      See identical proteins and their annotated locations for XP_008769083.1

      UniProtKB/TrEMBL
      A0A8L2R3I1
      Conserved Domains (3) summary
      COG5184
      Location:83 → 363
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd18354
      Location:350 → 466
      BTB_POZ_RCBTB2_CHC1L; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)
      cd18529
      Location:463 → 527
      BACK_RCBTB2; BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)

    14. XM_008770860.4 → XP_008769082.1  RCC1 and BTB domain-containing protein 2 isoform X2

      See identical proteins and their annotated locations for XP_008769082.1

      UniProtKB/TrEMBL
      A0A8L2R3I1
      Conserved Domains (3) summary
      COG5184
      Location:83 → 363
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd18354
      Location:350 → 466
      BTB_POZ_RCBTB2_CHC1L; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)
      cd18529
      Location:463 → 527
      BACK_RCBTB2; BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)

    15. XM_039093167.2 → XP_038949095.1  RCC1 and BTB domain-containing protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q6P798
      UniProtKB/TrEMBL
      A0A8L2R3I1, A6HTQ0
      Conserved Domains (3) summary
      COG5184
      Location:107 → 387
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd18354
      Location:374 → 490
      BTB_POZ_RCBTB2_CHC1L; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)
      cd18529
      Location:487 → 551
      BACK_RCBTB2; BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)

    16. XM_063274149.1 → XP_063130219.1  RCC1 and BTB domain-containing protein 2 isoform X2

    17. XM_039093164.2 → XP_038949092.1  RCC1 and BTB domain-containing protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q6P798
      UniProtKB/TrEMBL
      A0A8L2R3I1, A6HTQ0
      Conserved Domains (3) summary
      COG5184
      Location:107 → 387
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd18354
      Location:374 → 490
      BTB_POZ_RCBTB2_CHC1L; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)
      cd18529
      Location:487 → 551
      BACK_RCBTB2; BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P798.1 GenPept UniProtKB/Swiss-Prot:Q6P798

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