Pitpnc1 phosphatidylinositol transfer protein, cytoplasmic 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pitpnc1provided by RGD
Official Full Name: phosphatidylinositol transfer protein, cytoplasmic 1provided by RGD
Primary source: RGD:1597047
See related: Ensembl:ENSRNOG00000069160 AllianceGenome:RGD:1597047
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable phospholipid binding activity and phospholipid transfer activity. Predicted to be involved in phospholipid transport and signal transduction. Predicted to be located in cytosol and nucleoplasm. Orthologous to human PITPNC1 (phosphatidylinositol transfer protein cytoplasmic 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 128.2), Lung (RPKM 87.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q32.1

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (92663260..92928616, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (92163558..92428971, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (95429879..95697734, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

BF403105 (e-PCR)
- UniSTS:246306

d10mgh4 (e-PCR)
- UniSTS:120621

D10Got143 (e-PCR)
- UniSTS:114479

AU046465 (e-PCR)
- UniSTS:111421

D10Mco74 (e-PCR)
- UniSTS:240253

D10Rat15 (e-PCR)
- UniSTS:118160

D10Chm10 (e-PCR)
- UniSTS:518313

D10Chm158 (e-PCR)
- UniSTS:518058

AI234880 (e-PCR)
- UniSTS:261555

AU046606 (e-PCR)
- UniSTS:111292

RH127839 (e-PCR)
- UniSTS:211149

D10Chm238 (e-PCR)
- UniSTS:518094

D10Chm20 (e-PCR)
- UniSTS:518124

D10Got144 (e-PCR)
- UniSTS:114171

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables phosphatidic acid binding	ISO Inferred from Sequence Orthology more info
enables phosphatidic acid transfer activity	ISO Inferred from Sequence Orthology more info
NOT enables phosphatidylcholine transporter activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylglycerol binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol transfer activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in intermembrane lipid transfer	IEA Inferred from Electronic Annotation more info
involved_in phospholipid transport	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cytoplasmic phosphatidylinositol transfer protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001427418.1 → NP_001414347.1 cytoplasmic phosphatidylinositol transfer protein 1 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

A0A8I6AKK7
NM_001427419.1 → NP_001414348.1 cytoplasmic phosphatidylinositol transfer protein 1 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

A0A8I5ZSD8

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

92663260..92928616 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039087430.2 → XP_038943358.1 cytoplasmic phosphatidylinositol transfer protein 1 isoform X1

Conserved Domains (2) summary

cd08890
Location:2 → 250

SRPBCC_PITPNC1_like; Lipid-binding SRPBCC domain of mammalian PITPNC1,and related proteins (Class IIB PITPs)

NF033839
Location:292 → 414

PspC_subgroup_2; pneumococcal surface protein PspC, LPXTG-anchored form