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    Mon2 MON2 homolog, regulator of endosome-to-Golgi trafficking [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314894, updated on 4-Apr-2024

    Summary

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    Official Symbol
    Mon2provided by RGD
    Official Full Name
    MON2 homolog, regulator of endosome-to-Golgi traffickingprovided by RGD
    Primary source
    RGD:1308808
    See related
    Ensembl:ENSRNOG00000004185 AllianceGenome:RGD:1308808
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1308808
    Summary
    Predicted to be involved in protein transport. Predicted to be located in early endosome membrane. Orthologous to human MON2 (MON2 homolog, regulator of endosome-to-Golgi trafficking). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 200.0), Kidney (RPKM 185.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mon2 in Genome Data Viewer
    Location:
    7q22
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (60534772..60613467, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (58649378..58728102, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (66717470..66794041)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent, 1H Neighboring gene uncharacterized LOC134479883 Neighboring gene nascent polypeptide-associated complex subunit alpha, muscle-specific form-like Neighboring gene microRNA let-7i Neighboring gene SNRPN upstream reading frame protein-like Neighboring gene SNRPN upstream open reading frame like 1 Neighboring gene uncharacterized LOC134479704 Neighboring gene ubiquitin specific peptidase 15 Neighboring gene small nucleolar RNA, H/ACA box 19

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC125084

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in Golgi to endosome transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in early endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein MON2 homolog
    Names
    MON2 regulator of endosome-to-Golgi trafficking

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001040176.4 → NP_001035266.2  protein MON2 homolog isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      D3ZKH2
      Conserved Domains (4) summary
      pfam09324
      Location:869 → 928
      DUF1981; Domain of unknown function (DUF1981)
      pfam12783
      Location:211 → 378
      Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
      pfam16206
      Location:931 → 1699
      Mon2_C; C-terminal region of Mon2 protein
      pfam16213
      Location:9 → 183
      DCB; Dimerization and cyclophilin-binding domain of Mon2

    2. NM_001414945.2 → NP_001401874.1  protein MON2 homolog isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      D3ZCG3
      Related
      ENSRNOP00000005654.5, ENSRNOT00000005654.7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      60534772..60613467 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063263503.1 → XP_063119573.1  protein MON2 homolog isoform X1

    2. XM_063263504.1 → XP_063119574.1  protein MON2 homolog isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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