U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Cers2 ceramide synthase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 310667, updated on 5-Mar-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Cers2provided by RGD
    Official Full Name
    ceramide synthase 2provided by RGD
    Primary source
    RGD:1310059
    See related
    Ensembl:ENSRNOG00000021138 AllianceGenome:RGD:1310059
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Lass2
    Summary
    Predicted to enable sphingosine N-acyltransferase activity. Involved in negative regulation of Schwann cell migration; negative regulation of Schwann cell proliferation involved in axon regeneration; and negative regulation of axon regeneration. Predicted to be located in endoplasmic reticulum membrane and nucleus. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum. Orthologous to human CERS2 (ceramide synthase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Liver (RPKM 637.0), Lung (RPKM 320.5) and 9 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Cers2 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (185579511..185587789)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (182890527..182898805)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (196487656..196495930)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene MINDY lysine 48 deubiquitinase 1 Neighboring gene annexin A9 Neighboring gene SET domain bifurcated histone lysine methyltransferase 1 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC134485650

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. miR-221 and miR-222 promote Schwann cell proliferation and migration by targeting LASS2 after sciatic nerve injury. Yu B, et al. J Cell Sci, 2012 Jun 1. PMID 22393241
    2. Characterization of ceramide synthase 2: tissue distribution, substrate specificity, and inhibition by sphingosine 1-phosphate. Laviad EL, et al. J Biol Chem, 2008 Feb 29. PMID 18165233
    3. Enriched Environment Enhances the Myelin Regulatory Factor by mTOR Signaling and Protects the Myelin Membrane Against Oxidative Damage in Rats Exposed to Chronic Immobilization Stress. Thamizhoviya G, et al. Neurochem Res, 2021 Dec. PMID 34449011
    4. Eleven residues determine the acyl chain specificity of ceramide synthases. Tidhar R, et al. J Biol Chem, 2018 Jun 22. PMID 29632068, Free PMC Article
    5. Fam57b (family with sequence similarity 57, member B), a novel peroxisome proliferator-activated receptor γ target gene that regulates adipogenesis through ceramide synthesis. Yamashita-Sugahara Y, et al. J Biol Chem, 2013 Feb 15. PMID 23275342, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sciatic nerve injury promotes Schwann cell proliferation and migration through the regulation of miR-221/222 by targeting LASS2
      Title: miR-221 and miR-222 promote Schwann cell proliferation and migration by targeting LASS2 after sciatic nerve injury.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC124761

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables N-acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sphingosine N-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sphingosine N-acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in ceramide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within ceramide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ceramide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of Schwann cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of Schwann cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of Schwann cell proliferation involved in axon regeneration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of axon regeneration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of lipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to immobilization stress IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within sphingolipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    ceramide synthase 2
    Names
    LAG1 homolog, ceramide synthase 2
    NP_001028872.2
    XP_006232949.1
    XP_006232950.1
    XP_038958282.1
    XP_038958283.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033700.2 → NP_001028872.2  ceramide synthase 2

      See identical proteins and their annotated locations for NP_001028872.2

      Status: VALIDATED

      Source sequence(s)
      BC101876, BI284504, CF110567, CK365108
      UniProtKB/TrEMBL
      A6K2Y5, G3V8V4, Q3T1K1
      Related
      ENSRNOP00000028699.2, ENSRNOT00000028699.5
      Conserved Domains (2) summary
      smart00724
      Location:131 → 332
      TLC; TRAM, LAG1 and CLN8 homology domains
      cd00086
      Location:71 → 128
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      185579511..185587789
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006232888.4 → XP_006232950.1  ceramide synthase 2 isoform X1

      See identical proteins and their annotated locations for XP_006232950.1

      UniProtKB/TrEMBL
      A6K2Y5, G3V8V4, Q3T1K1
      Conserved Domains (2) summary
      smart00724
      Location:131 → 332
      TLC; TRAM, LAG1 and CLN8 homology domains
      cd00086
      Location:71 → 128
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

    2. XM_039102355.2 → XP_038958283.1  ceramide synthase 2 isoform X1

      UniProtKB/TrEMBL
      A6K2Y5, G3V8V4, Q3T1K1
      Conserved Domains (2) summary
      smart00724
      Location:131 → 332
      TLC; TRAM, LAG1 and CLN8 homology domains
      cd00086
      Location:71 → 128
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

    3. XM_039102354.2 → XP_038958282.1  ceramide synthase 2 isoform X1

      UniProtKB/TrEMBL
      A6K2Y5, G3V8V4, Q3T1K1
      Conserved Domains (2) summary
      smart00724
      Location:131 → 332
      TLC; TRAM, LAG1 and CLN8 homology domains
      cd00086
      Location:71 → 128
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

    4. XM_006232887.5 → XP_006232949.1  ceramide synthase 2 isoform X1

      See identical proteins and their annotated locations for XP_006232949.1

      UniProtKB/TrEMBL
      A6K2Y5, G3V8V4, Q3T1K1
      Conserved Domains (2) summary
      smart00724
      Location:131 → 332
      TLC; TRAM, LAG1 and CLN8 homology domains
      cd00086
      Location:71 → 128
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous