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    Ubash3b ubiquitin associated and SH3 domain containing, B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315579, updated on 30-Mar-2024

    Summary

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    Official Symbol
    Ubash3bprovided by RGD
    Official Full Name
    ubiquitin associated and SH3 domain containing, Bprovided by RGD
    Primary source
    RGD:1310357
    See related
    Ensembl:ENSRNOG00000008187 AllianceGenome:RGD:1310357
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Sts1; Sts-1; RGD1310357
    Summary
    Enables ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including collagen-activated tyrosine kinase receptor signaling pathway; negative regulation of bone resorption; and platelet aggregation. Predicted to act upstream of or within several processes, including negative regulation of osteoclast differentiation; negative regulation of platelet aggregation; and platelet activation. Predicted to be active in cytoplasm. Orthologous to human UBASH3B (ubiquitin associated and SH3 domain containing B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 85.5), Brain (RPKM 68.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ubash3b in Genome Data Viewer
    Location:
    8q22
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (50282510..50430034, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (41385419..41532248, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (45224053..45375450, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene junctional cadherin complex regulator Neighboring gene uncharacterized LOC134480157 Neighboring gene cytotoxic and regulatory T cell molecule Neighboring gene uncharacterized LOC134480159 Neighboring gene uncharacterized LOC102555115 Neighboring gene uncharacterized LOC102555203 Neighboring gene uncharacterized LOC120094126 Neighboring gene uncharacterized LOC120094124

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. TULA-2, a novel histidine phosphatase, regulates bone remodeling by modulating osteoclast function. Back SH, et al. Cell Mol Life Sci, 2013 Apr. PMID 23149425, Free PMC Article
    2. The adaptor molecule CIN85 regulates Syk tyrosine kinase level by activating the ubiquitin-proteasome degradation pathway. Peruzzi G, et al. J Immunol, 2007 Aug 15. PMID 17675467
    3. A novel histidine tyrosine phosphatase, TULA-2, associates with Syk and negatively regulates GPVI signaling in platelets. Thomas DH, et al. Blood, 2010 Oct 7. PMID 20585042, Free PMC Article
    4. TULA-2 Protein Phosphatase Suppresses Activation of Syk through the GPVI Platelet Receptor for Collagen by Dephosphorylating Tyr(P)346, a Regulatory Site of Syk. Reppschläger K, et al. J Biol Chem, 2016 Oct 21. PMID 27609517, Free PMC Article
    5. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphoprotein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within collagen-activated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in collagen-activated tyrosine kinase receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within collagen-activated tyrosine kinase receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of bone resorption IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of bone resorption ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of osteoclast differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of platelet aggregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-tyrosine dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within platelet activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in platelet aggregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within platelet aggregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of osteoclast differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of osteoclast differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of release of sequestered calcium ion into cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of release of sequestered calcium ion into cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin-associated and SH3 domain-containing protein B
    Names
    Cbl-interacting protein Sts-1
    NP_001178721.1
    XP_006242910.1
    XP_038937342.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191792.1 → NP_001178721.1  ubiquitin-associated and SH3 domain-containing protein B

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I5YC04
      Related
      ENSRNOP00000076960.1, ENSRNOT00000102848.1
      Conserved Domains (3) summary
      cd07067
      Location:375 → 587
      HP_PGM_like; Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
      cd11936
      Location:245 → 306
      SH3_UBASH3B; Src homology 3 domain of Ubiquitin-associated and SH3 domain-containing protein B
      cd14301
      Location:28 → 65
      UBA_UBS3B; UBA domain found in ubiquitin-associated and SH3 domain-containing protein B (UBS3B) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      50282510..50430034 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006242848.5 → XP_006242910.1  ubiquitin-associated and SH3 domain-containing protein B isoform X1

      UniProtKB/TrEMBL
      A0A8I5YC04
      Conserved Domains (3) summary
      cd07067
      Location:375 → 585
      HP_PGM_like; Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
      cd11936
      Location:245 → 306
      SH3_UBASH3B; Src homology 3 domain of Ubiquitin-associated and SH3 domain-containing protein B
      cd14301
      Location:28 → 65
      UBA_UBS3B; UBA domain found in ubiquitin-associated and SH3 domain-containing protein B (UBS3B) and similar proteins

    2. XM_039081414.2 → XP_038937342.1  ubiquitin-associated and SH3 domain-containing protein B isoform X2

      UniProtKB/TrEMBL
      A0A8I5YC04, F1LV21
      Related
      ENSRNOP00000010873.7
      Conserved Domains (2) summary
      cd07067
      Location:351 → 563
      HP_PGM_like; Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
      cd11936
      Location:221 → 282
      SH3_UBASH3B; Src homology 3 domain of Ubiquitin-associated and SH3 domain-containing protein B
    Nucleotide Protein Strain
    Heading Accession and Version

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