Bsn bassoon (presynaptic cytomatrix protein) [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Bsnprovided by RGD
Official Full Name: bassoon (presynaptic cytomatrix protein)provided by RGD
Primary source: RGD:2223
See related: Ensembl:ENSRNOG00000030714 AllianceGenome:RGD:2223
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Znf231
Summary: Enables dynein light chain binding activity and transcription corepressor binding activity. Involved in presynaptic active zone assembly; regulation of ubiquitin protein ligase activity; and retrograde axonal transport. Located in several cellular components, including axon cytoplasm; cytoplasmic vesicle; and cytoskeleton of presynaptic active zone. Is extrinsic component of membrane. Is active in several cellular components, including GABA-ergic synapse; hippocampal mossy fiber to CA3 synapse; and presynaptic active zone cytoplasmic component. Colocalizes with synaptic membrane. Orthologous to human BSN (bassoon presynaptic cytomatrix protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 76.4) and Adrenal (RPKM 21.7) See more
Orthologs: human mouse all
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Genomic context

Location:: 8q32

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (117663447..117754412, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (108784849..108875819, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (116873721..116965396, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The findings provide a mechanism for the presynaptic targeting of Trio and support a model in which Piccolo and Bassoon play a role in regulating neurotransmission through interactions with proteins, including Trio, that modulate the dynamic assembly of F-actin during cycles of synaptic vesicle exo- and endocytosis.
Title: Trio, a Rho Family GEF, Interacts with the Presynaptic Active Zone Proteins Piccolo and Bassoon.
CtBP1 is targeted and/or anchored to presynapses by direct interaction with the active zone scaffolding proteins Bassoon and piccolo.
Title: Synaptic activity controls localization and function of CtBP1 via binding to Bassoon and Piccolo.
phosphorylation-induced 14-3-3 binding to Bassoon modulates its anchoring to the presynaptic cytomatrix
Title: Regulation of presynaptic anchoring of the scaffold protein Bassoon by phosphorylation-dependent interaction with 14-3-3 adaptor proteins.
a novel role for Bassoon and Piccolo as critical regulators of presynaptic ubiquitination and proteostasis.
Title: Bassoon and Piccolo maintain synapse integrity by regulating protein ubiquitination and degradation.
Bassoon co-localizes with presynaptic calcium channel, modifies channel function, and recovers from aging related loss by exercise.
Title: Active zone protein Bassoon co-localizes with presynaptic calcium channel, modifies channel function, and recovers from aging related loss by exercise.
Data show that Bassoon colocalizes with Aczonin at conventional synapses, but in ribbon synapses, CAST, Munc13, and RIM are segregated from Aczonin, and Aczonin is positioned and may control the access of neurotransmitter vesicles to the fusion site.
Title: Molecular in situ topology of Aczonin/Piccolo and associated proteins at the mammalian neurotransmitter release site.
D-amino acid oxidase activity is inhibited by an interaction with bassoon protein at the presynaptic active zone.
Title: D-amino acid oxidase activity is inhibited by an interaction with bassoon protein at the presynaptic active zone.
The total number of Bassoon and Piccolo clusters may contribute to the functional maturation associated with hearing onset.
Title: Targeted three-dimensional immunohistochemistry reveals localization of presynaptic proteins Bassoon and Piccolo in the rat calyx of Held before and after the onset of hearing.
Data show that Bassoon functions as a cargo adapter for retrograde transport and that disruption of the Bassoon-dynein light chain 1/2 interactions leads to impaired trafficking of Bassoon and affects distribution of Bassoon and Piccolo among synapses.
Title: Dynein light chain regulates axonal trafficking and synaptic levels of Bassoon.
Results suggest that a primordial cytomatrix assembles in a trans-Golgi compartment, and that transport via Golgi-derived vesicles is essential for delivery of cytomatrix proteins such as bassoon and piccolo to the synapse.
Title: Assembly of active zone precursor vesicles: obligatory trafficking of presynaptic cytomatrix proteins Bassoon and Piccolo via a trans-Golgi compartment.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

d8rat67 (e-PCR)
- UniSTS:122466

BF387500 (e-PCR)
- UniSTS:244390

D8Wox11 (e-PCR)
- UniSTS:228314

BE097610 (e-PCR)
- UniSTS:244704

D8Wox32 (e-PCR)
- UniSTS:518900

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables dynein light chain binding	IPI Inferred from Physical Interaction more info	PubMed
enables enzyme inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of presynaptic active zone	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of presynaptic active zone	IEA Inferred from Electronic Annotation more info
enables structural constituent of presynaptic active zone	ISO Inferred from Sequence Orthology more info
enables transcription corepressor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in axo-dendritic transport	IDA Inferred from Direct Assay more info	PubMed
involved_in cytoskeleton organization	NAS Non-traceable Author Statement more info	PubMed
involved_in maintenance of presynaptic active zone structure	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within maintenance of presynaptic active zone structure	ISO Inferred from Sequence Orthology more info
involved_in modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in presynapse to nucleus signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in presynapse to nucleus signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in presynaptic active zone assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in presynaptic active zone assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in protein localization to synapse	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to synapse	IEA Inferred from Electronic Annotation more info
involved_in protein localization to synapse	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic vesicle cycle	IEA Inferred from Electronic Annotation more info
involved_in regulation of synaptic vesicle cycle	ISO Inferred from Sequence Orthology more info
involved_in retrograde axonal transport	IDA Inferred from Direct Assay more info	PubMed
involved_in synapse organization	IDA Inferred from Direct Assay more info	PubMed
involved_in synaptic vesicle clustering	IEA Inferred from Electronic Annotation more info
involved_in synaptic vesicle clustering	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	IBA Inferred from Biological aspect of Ancestor more info
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in GABA-ergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
located_in Golgi-associated vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in Schaffer collateral - CA1 synapse	IEA Inferred from Electronic Annotation more info
is_active_in Schaffer collateral - CA1 synapse	ISO Inferred from Sequence Orthology more info
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in axon	IEA Inferred from Electronic Annotation more info
located_in axon	ISO Inferred from Sequence Orthology more info
located_in axon cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cochlear hair cell ribbon synapse	IEA Inferred from Electronic Annotation more info
is_active_in cochlear hair cell ribbon synapse	ISO Inferred from Sequence Orthology more info
is_active_in cytoskeleton of presynaptic active zone	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoskeleton of presynaptic active zone	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in excitatory synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IBA Inferred from Biological aspect of Ancestor more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in hippocampal mossy fiber to CA3 synapse	IDA Inferred from Direct Assay more info	PubMed
located_in inhibitory synapse	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection terminus	IEA Inferred from Electronic Annotation more info
located_in neuron projection terminus	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in piccolo-bassoon transport vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density	IEA Inferred from Electronic Annotation more info
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
located_in presynapse	ISO Inferred from Sequence Orthology more info
located_in presynaptic active zone	IDA Inferred from Direct Assay more info	PubMed
located_in presynaptic active zone	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic active zone cytoplasmic component	IDA Inferred from Direct Assay more info	PubMed
located_in presynaptic active zone cytoplasmic component	IEA Inferred from Electronic Annotation more info
located_in presynaptic active zone cytoplasmic component	ISO Inferred from Sequence Orthology more info
located_in ribbon synapse	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	ISO Inferred from Sequence Orthology more info
located_in synaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in trans-Golgi network	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: protein bassoon

Names: neuronal double zinc finger protein; zinc finger protein 231

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.