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    Prune1 prune exopolyphosphatase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 310664, updated on 2-May-2024

    Summary

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    Official Symbol
    Prune1provided by RGD
    Official Full Name
    prune exopolyphosphatase 1provided by RGD
    Primary source
    RGD:1359521
    See related
    Ensembl:ENSRNOG00000021120 AllianceGenome:RGD:1359521
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Prune
    Summary
    Predicted to enable exopolyphosphatase activity; phosphatase activity; and tubulin binding activity. Predicted to be involved in regulation of microtubule polymerization and regulation of neurogenesis. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to human PRUNE1 (prune exopolyphosphatase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 86.2), Muscle (RPKM 81.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Prune1 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (185519569..185548402, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (182830575..182859972, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (196427714..196457105, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene similar to human chromosome 1 open reading frame 56 Neighboring gene BCL2 interacting protein like Neighboring gene MINDY lysine 48 deubiquitinase 1 Neighboring gene annexin A9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. PRUNE is crucial for normal brain development and mutated in microcephaly with neurodevelopmental impairment. Zollo M, et al. Brain, 2017 Apr 1. PMID 28334956, Free PMC Article
    2. Evidence for interaction between human PRUNE and nm23-H1 NDPKinase. Reymond A, et al. Oncogene, 1999 Dec 2. PMID 10602478
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC93997

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables exopolyphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables inorganic diphosphate phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables pyrophosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tubulin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in regulation of microtubule polymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of neurogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    exopolyphosphatase PRUNE1
    Names
    protein prune homolog
    prune homolog
    NP_001007698.1
    XP_006232947.1
    XP_017446388.1
    XP_063137943.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007697.1 → NP_001007698.1  exopolyphosphatase PRUNE1

      See identical proteins and their annotated locations for NP_001007698.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079054
      UniProtKB/Swiss-Prot
      Q6AYG3
      UniProtKB/TrEMBL
      A0A8I6AAC6
      Related
      ENSRNOP00000028677.4, ENSRNOT00000028677.6
      Conserved Domains (2) summary
      PRK05427
      Location:20 → 361
      PRK05427; putative manganese-dependent inorganic pyrophosphatase; Provisional
      pfam02833
      Location:218 → 357
      DHHA2; DHHA2 domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      185519569..185548402 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006232885.5 → XP_006232947.1  exopolyphosphatase PRUNE1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AAC6
      Conserved Domains (2) summary
      COG1227
      Location:21 → 253
      PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
      pfam02833
      Location:218 → 304
      DHHA2; DHHA2 domain

    2. XM_017590899.3 → XP_017446388.1  exopolyphosphatase PRUNE1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AAC6
      Related
      ENSRNOP00000089468.1
      Conserved Domains (2) summary
      COG1227
      Location:66 → 255
      PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
      pfam02833
      Location:187 → 327
      DHHA2; DHHA2 domain

    3. XM_063281873.1 → XP_063137943.1  exopolyphosphatase PRUNE1 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AYG3.1 GenPept UniProtKB/Swiss-Prot:Q6AYG3

    Gene LinkOut

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