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    Aff1 ALF transcription elongation factor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305152, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Aff1provided by RGD
    Official Full Name
    ALF transcription elongation factor 1provided by RGD
    Primary source
    RGD:1307940
    See related
    Ensembl:ENSRNOG00000002232 AllianceGenome:RGD:1307940
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mllt2
    Summary
    Predicted to be involved in regulation of gene expression. Predicted to act upstream of or within positive regulation of transcription, DNA-templated. Predicted to be located in nucleus. Predicted to be part of super elongation complex. Orthologous to human AFF1 (AF4/FMR2 family member 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 151.4), Kidney (RPKM 145.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Aff1 in Genome Data Viewer
    Location:
    14p22
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (6165864..6328848, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (5861188..6024196, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (7222883..7384916, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene hydroxysteroid (17-beta) dehydrogenase 13 Neighboring gene uncharacterized LOC120096561 Neighboring gene kelch-like family member 8 Neighboring gene similar to human chromosome 4 open reading frame 36 Neighboring gene uncharacterized LOC102546534

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cloning and developmental expression of the murine homolog of the acute leukemia proto-oncogene AF4. Baskaran K, et al. Oncogene, 1997 Oct 16. PMID 9365243
    2. The super elongation complex (SEC) family in transcriptional control. Luo Z, et al. Nat Rev Mol Cell Biol, 2012 Sep. PMID 22895430
    3. The little elongation complex regulates small nuclear RNA transcription. Smith ER, et al. Mol Cell, 2011 Dec 23. PMID 22195968, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of super elongation complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription elongation factor complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    AF4/FMR2 family member 1
    Names
    AF4/FMR2 family, member 1
    myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)
    myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 2
    translocated to, 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107206.1 → NP_001100676.1  AF4/FMR2 family member 1

      See identical proteins and their annotated locations for NP_001100676.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474022
      UniProtKB/TrEMBL
      A0A0G2K0C8, A6K5U8
      Related
      ENSRNOP00000071392.2, ENSRNOT00000086694.2
      Conserved Domains (1) summary
      pfam05110
      Location:18 → 1111
      AF-4; AF-4 proto-oncoprotein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      6165864..6328848 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006250632.5 → XP_006250694.2  AF4/FMR2 family member 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AP86, D3ZBU5
      Related
      ENSRNOP00000062389.2
      Conserved Domains (4) summary
      PRK03427
      Location:514 → 638
      PRK03427; cell division protein ZipA; Provisional
      pfam05110
      Location:12 → 510
      AF-4; AF-4 proto-oncoprotein
      pfam18875
      Location:771 → 785
      AF4_int; AF4 interaction motif
      pfam18876
      Location:960 → 1221
      AF-4_C; AF-4 proto-oncoprotein C-terminal region

    2. XM_006250633.5 → XP_006250695.2  AF4/FMR2 family member 1 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AP86, A0A8I6B3L8
      Related
      ENSRNOP00000096010.1
      Conserved Domains (4) summary
      PRK03427
      Location:510 → 634
      PRK03427; cell division protein ZipA; Provisional
      pfam05110
      Location:8 → 506
      AF-4; AF-4 proto-oncoprotein
      pfam18875
      Location:767 → 781
      AF4_int; AF4 interaction motif
      pfam18876
      Location:956 → 1217
      AF-4_C; AF-4 proto-oncoprotein C-terminal region

    3. XM_039091821.2 → XP_038947749.1  AF4/FMR2 family member 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AP86
      Conserved Domains (5) summary
      PRK03427
      Location:519 → 643
      PRK03427; cell division protein ZipA; Provisional
      PRK14971
      Location:588 → 720
      PRK14971; DNA polymerase III subunit gamma/tau
      pfam05110
      Location:17 → 515
      AF-4; AF-4 proto-oncoprotein
      pfam18875
      Location:776 → 790
      AF4_int; AF4 interaction motif
      pfam18876
      Location:965 → 1226
      AF-4_C; AF-4 proto-oncoprotein C-terminal region
    Nucleotide Protein Strain
    Heading Accession and Version

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