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    Amt aminomethyltransferase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306586, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Amtprovided by RGD
    Official Full Name
    aminomethyltransferaseprovided by RGD
    Primary source
    RGD:1359408
    See related
    Ensembl:ENSRNOG00000050214 AllianceGenome:RGD:1359408
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable aminomethyltransferase activity. Predicted to be involved in glycine decarboxylation via glycine cleavage system. Predicted to be located in nucleoplasm. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in glycine encephalopathy. Orthologous to human AMT (aminomethyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 362.2), Liver (RPKM 173.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Amt in Genome Data Viewer
    Location:
    8q32
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (117859700..117866692)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (108981620..108988127)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (117068388..117078633)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene bassoon (presynaptic cytomatrix protein) Neighboring gene dystroglycan 1 Neighboring gene small nuclear ribonucleoprotein D2 polypeptide, pseudogene 3 Neighboring gene nicolin 1, tubulin polyglutamylase complex subunit Neighboring gene U6 snRNA-associated Sm-like protein LSm3 Neighboring gene T-cell leukemia translocation altered Neighboring gene ras homolog family member A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Increased activity of renal glycine-cleavage-enzyme complex in metabolic acidosis. Lowry M, et al. Biochem J, 1985 Oct 15. PMID 3877504, Free PMC Article
    2. Crystal structure of human T-protein of glycine cleavage system at 2.0 A resolution and its implication for understanding non-ketotic hyperglycinemia. Okamura-Ikeda K, et al. J Mol Biol, 2005 Sep 2. PMID 16051266
    3. A one-base deletion (183delC) and a missense mutation (D276H) in the T-protein gene from a Japanese family with nonketotic hyperglycinemia. Kure S, et al. J Hum Genet, 1998. PMID 9621520
    4. A missense mutation (His42Arg) in the T-protein gene from a large Israeli-Arab kindred with nonketotic hyperglycinemia. Kure S, et al. Hum Genet, 1998 Apr. PMID 9600239
    5. Identification of the mutations in the T-protein gene causing typical and atypical nonketotic hyperglycinemia. Nanao K, et al. Hum Genet, 1994 Jun. PMID 8005589

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables aminomethyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in glycine decarboxylation via glycine cleavage system ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    aminomethyltransferase, mitochondrial
    Names
    aminomethyltransferase (glycine cleavage system protein T)
    NP_001014026.1
    XP_038937253.1
    XP_063121391.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014004.2 → NP_001014026.1  aminomethyltransferase, mitochondrial

      See identical proteins and their annotated locations for NP_001014026.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      M0R9I6, Q5XI85
      Related
      ENSRNOP00000066155.3, ENSRNOT00000073559.3
      Conserved Domains (3) summary
      PLN02319
      Location:16 → 400
      PLN02319; aminomethyltransferase
      pfam01571
      Location:39 → 291
      GCV_T; Aminomethyltransferase folate-binding domain
      pfam08669
      Location:301 → 392
      GCV_T_C; Glycine cleavage T-protein C-terminal barrel domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      117859700..117866692
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063265321.1 → XP_063121391.1  aminomethyltransferase, mitochondrial isoform X2

    2. XM_039081325.1 → XP_038937253.1  aminomethyltransferase, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A8I6A0K6, M0R9I6
      Related
      ENSRNOP00000083744.1, ENSRNOT00000113499.1
      Conserved Domains (1) summary
      cl39066
      Location:16 → 405
      GCV_T; Aminomethyltransferase folate-binding domain
    Nucleotide Protein Strain
    Heading Accession and Version

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