Ensa endosulfine alpha [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ensaprovided by RGD
Official Full Name: endosulfine alphaprovided by RGD
Primary source: RGD:62007
See related: Ensembl:ENSRNOG00000048617 AllianceGenome:RGD:62007
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including potassium channel inhibitor activity; protein phosphatase 2A binding activity; and protein phosphatase inhibitor activity. Involved in response to glucose. Located in cytoplasm. Orthologous to human ENSA (endosulfine alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 459.1), Muscle (RPKM 435.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q34

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (185874500..185881838)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (183185552..183192888)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (197752544..197759882)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study demonstrated that the alphaEnsa levels are significantly upregulated in mammalian brain at various times following the onset of ischemia/reperfusion. Protein upregulation was detected as early as 2 hours after ischemic onset, with sustained upregulation noted subsequently over several days
Title: α-Endosulfine (ARPP-19e) Expression in a Rat Model of Stroke.
localization in pancreatic somatostatin delta cells and expression during rat pancreas development
Title: Localization of alpha-endosulphine in pancreatic somatostatin delta cells and expression during rat pancreas development.
results suggest that alpha-endosulfine gene expression is differentially regulated by distinct brain processes involving excitatory neuronal activities
Title: Gene expression of alpha-endosulfine in the rat brain: correlative changes with aging, learning and stress.
ENSA and alpha-endosulfine are expressed in glomeruli and mesangial cells, and gene and protein expression are up-regulated by a high glucose environment.
Title: Rat mesangial alpha-endosulfine.

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General gene information

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Markers

D7S1557 (e-PCR)
- UniSTS:63047

RH129111 (e-PCR)
- UniSTS:212419

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables phosphatase inhibitor activity	ISS Inferred from Sequence or Structural Similarity more info
enables potassium channel inhibitor activity	IEA Inferred from Electronic Annotation more info
enables potassium channel inhibitor activity	ISO Inferred from Sequence Orthology more info
enables potassium channel regulator activity	NAS Non-traceable Author Statement more info	PubMed
enables protein phosphatase 2A binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein phosphatase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein phosphatase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables protein phosphatase regulator activity	ISS Inferred from Sequence or Structural Similarity more info
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G2/M transition of mitotic cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in mitotic cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of protein dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of insulin secretion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in response to glucose	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: alpha-endosulfine

Names: ARPP-19e

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033974.2 → NP_001029146.1 alpha-endosulfine isoform 1

See identical proteins and their annotated locations for NP_001029146.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes isoform 1.

Source sequence(s)

BC059135, JAXUCZ010000002

UniProtKB/TrEMBL

A0A8I6G7F4, A6K303

Related

ENSRNOP00000083613.1, ENSRNOT00000104132.1

Conserved Domains (1) summary

pfam04667
Location:33 → 86

Endosulfine; cAMP-regulated phosphoprotein/endosulfine conserved region
NM_021842.3 → NP_068614.1 alpha-endosulfine isoform 2

See identical proteins and their annotated locations for NP_068614.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region and a different 3' terminal exon compared to variant 1. The resulting protein (isoform 2) is longer and has a distinct C-terminus compared to isoform 1.

Source sequence(s)

CB812628, JAXUCZ010000002

UniProtKB/Swiss-Prot

P60841, Q6PCU7

UniProtKB/TrEMBL

A0A8I6G7F4, A6K302

Related

ENSRNOP00000063946.1, ENSRNOT00000075511.3

Conserved Domains (1) summary

pfam04667
Location:33 → 86

Endosulfine; cAMP-regulated phosphoprotein/endosulfine conserved region