Vcpip1 valosin containing protein interacting protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Vcpip1provided by RGD
Official Full Name: valosin containing protein interacting protein 1provided by RGD
Primary source: RGD:708520
See related: Ensembl:ENSRNOG00000006980 AllianceGenome:RGD:708520
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Vcip135
Summary: Enables thiol-dependent deubiquitinase. Involved in several processes, including Golgi reassembly; endoplasmic reticulum membrane fusion; and protein ubiquitination. Predicted to be located in cytoplasm and nucleus. Predicted to be active in synapse. Orthologous to human VCPIP1 (valosin containing protein interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 228.0), Thymus (RPKM 214.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q11

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (14317083..14343724)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (9534247..9560889)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (9231180..9257821)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

WAC is hence thought to function in p97/p47-mediated Golgi membrane fusion by activating the deubiquitinating function of VCIP135.
Title: VCIP135 deubiquitinase and its binding protein, WAC, in p97ATPase-mediated membrane fusion.
Electrical stimulation increased valosin-containing protein (VCP) expression and decreased cleaved caspase-12 expression in denervated muscles.
Title: Electrical stimulation prevents apoptosis in denervated skeletal muscle.
VCIP135 is required for golgi and endoplasmic reticulum assembly.
Title: VCIP135, a novel essential factor for p97/p47-mediated membrane fusion, is required for Golgi and ER assembly in vivo.
p97-p47-mediated reassembly of Golgi cisternae requires ubiquitin, but is not dependent on proteasome-mediated proteolysis.
Title: VCIP135 acts as a deubiquitinating enzyme during p97-p47-mediated reassembly of mitotic Golgi fragments.
Expression is ignificant in the prognosis of esophageal squamous cell carcinoma
Title: Expression level of valosin-containing protein (p97) is associated with prognosis of esophageal carcinoma.
P47 localizes to the nucleus during interphase and is phosphorylated on Serine-140 by Cdc2 at mitosis. Phosphorylated p47 does not bind to Golgi membranes.
Title: The localization and phosphorylation of p47 are important for Golgi disassembly-assembly during the cell cycle.
findings clearly reveal that native CYPs 3A undergo UPD and implicate a role for p97 in this process.
Title: Characterization of the physiological turnover of native and inactivated cytochromes P450 3A in cultured rat hepatocytes: a role for the cytosolic AAA ATPase p97?

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General gene information

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Markers

RH142499 (e-PCR)
- UniSTS:231746

D1Mit296 (e-PCR), detects polymorphism
- UniSTS:128649

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cysteine-type deubiquitinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type deubiquitinase activity	IDA Inferred from Direct Assay more info	PubMed
enables cysteine-type deubiquitinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response	ISS Inferred from Sequence or Structural Similarity more info
involved_in Golgi organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Golgi reassembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in Golgi reassembly	IDA Inferred from Direct Assay more info	PubMed
involved_in endoplasmic reticulum membrane fusion	IBA Inferred from Biological aspect of Ancestor more info
involved_in endoplasmic reticulum membrane fusion	IDA Inferred from Direct Assay more info	PubMed
involved_in protein K11-linked deubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein K48-linked deubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein-DNA covalent cross-linking repair	ISO Inferred from Sequence Orthology more info
involved_in protein-DNA covalent cross-linking repair	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein localization to chromatin	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein localization to chromatin	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi stack	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
is_active_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: deubiquitinating protein VCPIP1

Names: VCP(p97)/p47-interacting protein; VCP/p47 complex-interacting 135-kDa protein; deubiquitinating protein VCIP135; valosin-containing protein (p97)/p47 complex-interacting protein 135; valosin-containing protein p97/p47 complex-interacting protein 1; valosin-containing protein p97/p47 complex-interacting protein p135

NP_789827.3

EC 3.4.19.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.