Necap1 NECAP endocytosis associated 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Necap1provided by RGD
Official Full Name: NECAP endocytosis associated 1provided by RGD
Primary source: RGD:1306053
See related: Ensembl:ENSRNOG00000009236 AllianceGenome:RGD:1306053
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1306053
Summary: Predicted to be involved in endocytosis. Predicted to be located in clathrin-coated pit. Predicted to be part of clathrin vesicle coat. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 21. Orthologous to human NECAP1 (NECAP endocytosis associated 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 482.0), Kidney (RPKM 171.7) and 9 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 4q42

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (157775890..157790992)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (156103935..156119068)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (155709712..155724801)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NECAP 1 plays a role in clathrin-mediated neuronal endocytosis, including a role in presynaptic endocytosis. (NECAP 1)
Title: Characterization of the localization and function of NECAP 1 in neurons.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

AA998017 (e-PCR)
- UniSTS:248609

RH141222 (e-PCR)
- UniSTS:223218

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in endocytosis	IEA Inferred from Electronic Annotation more info
involved_in endocytosis	ISO Inferred from Sequence Orthology more info
involved_in presynaptic endocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in presynaptic endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of clathrin vesicle coat	IBA Inferred from Biological aspect of Ancestor more info
part_of clathrin vesicle coat	IEA Inferred from Electronic Annotation more info
part_of clathrin vesicle coat	ISO Inferred from Sequence Orthology more info
located_in clathrin-coated pit	IEA Inferred from Electronic Annotation more info
located_in clathrin-coated pit	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in presynapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: adaptin ear-binding coat-associated protein 1

Names: NECAP endocytosis-associated protein 1; NECAP-1; adaptin ear-binding clathrin-associated protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001029919.2 → NP_001025090.1 adaptin ear-binding coat-associated protein 1

See identical proteins and their annotated locations for NP_001025090.1

Status: VALIDATED

Source sequence(s)

BC097496, CO402572

UniProtKB/Swiss-Prot

P69682, Q4QR67

UniProtKB/TrEMBL

A0A8L2Q6N8, A6ILG2

Conserved Domains (1) summary

pfam07933
Location:7 → 164

DUF1681; Protein of unknown function (DUF1681)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

157775890..157790992

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006237305.3 → XP_006237367.1 adaptin ear-binding coat-associated protein 1 isoform X1

UniProtKB/TrEMBL

A0A8L2Q6N8

Related

ENSRNOP00000013272.6

Conserved Domains (1) summary

pfam07933
Location:11 → 143

DUF1681; Protein of unknown function (DUF1681)