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    Mmp23 matrix metallopeptidase 23 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 94339, updated on 2-May-2024

    Summary

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    Official Symbol
    Mmp23provided by RGD
    Official Full Name
    matrix metallopeptidase 23provided by RGD
    Primary source
    RGD:620201
    See related
    Ensembl:ENSRNOG00000017477 AllianceGenome:RGD:620201
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable metalloendopeptidase activity. Predicted to be involved in several processes, including collagen catabolic process; extracellular matrix organization; and proteolysis. Predicted to be located in endoplasmic reticulum membrane and extracellular matrix. Predicted to be integral component of membrane. Predicted to be active in extracellular space. Orthologous to human MMP23B (matrix metallopeptidase 23B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Uterus (RPKM 90.0), Spleen (RPKM 53.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mmp23 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (171521905..171525007, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (166239643..166242734, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (173078811..173082834, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 35, member E2B Neighboring gene cyclin-dependent kinase 11B Neighboring gene ribosomal protein L27A like 10 Neighboring gene MIB E3 ubiquitin protein ligase 2 Neighboring gene eukaryotic translation elongation factor 1 gamma, pseudogene 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Intracellular trafficking of the KV1.3 potassium channel is regulated by the prodomain of a matrix metalloprotease. Nguyen HM, et al. J Biol Chem, 2013 Mar 1. PMID 23300077, Free PMC Article
    2. Cloning and characterization of a rat ortholog of MMP-23 (matrix metalloproteinase-23), a unique type of membrane-anchored matrix metalloproteinase and conditioned switching of its expression during the ovarian follicular development. Ohnishi J, et al. Mol Endocrinol, 2001 May. PMID 11328856
    3. Cloning and characterization of human MMP-23, a new matrix metalloproteinase predominantly expressed in reproductive tissues and lacking conserved domains in other family members. Velasco G, et al. J Biol Chem, 1999 Feb 19. PMID 9988691
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metalloendopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in collagen catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in extracellular matrix organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    matrix metalloproteinase-23
    Names
    MIFR
    MMP-23
    Matrix metalloproteinase 23
    metalloprotease in the female reproductive tract
    metaloprotease in the female reproductive tract

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053606.2 → NP_446058.1  matrix metalloproteinase-23

      See identical proteins and their annotated locations for NP_446058.1

      Status: PROVISIONAL

      Source sequence(s)
      BC086586
      UniProtKB/Swiss-Prot
      O88272
      UniProtKB/TrEMBL
      A6IUR3
      Related
      ENSRNOP00000061528.2, ENSRNOT00000066880.4
      Conserved Domains (4) summary
      smart00254
      Location:256 → 290
      ShKT; ShK toxin domain
      cd04278
      Location:88 → 255
      ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
      pfam00413
      Location:88 → 255
      Peptidase_M10; Matrixin
      cl11960
      Location:314 → 376
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      171521905..171525007 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039110897.2 → XP_038966825.1  matrix metalloproteinase-23 isoform X3

      Conserved Domains (4) summary
      smart00254
      Location:218 → 252
      ShKT; ShK toxin domain
      cd04278
      Location:88 → 217
      ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
      cd00096
      Location:294 → 298
      Ig; Ig strand C [structural motif]
      cl11960
      Location:276 → 338
      Ig; Immunoglobulin domain

    2. XM_039110895.2 → XP_038966823.1  matrix metalloproteinase-23 isoform X1

      Conserved Domains (4) summary
      smart00254
      Location:251 → 285
      ShKT; ShK toxin domain
      cd04278
      Location:88 → 250
      ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
      cd00096
      Location:327 → 331
      Ig; Ig strand C [structural motif]
      cl11960
      Location:309 → 371
      Ig; Immunoglobulin domain

    3. XM_039110896.2 → XP_038966824.1  matrix metalloproteinase-23 isoform X2

      Conserved Domains (4) summary
      smart00254
      Location:245 → 279
      ShKT; ShK toxin domain
      cd04278
      Location:88 → 244
      ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
      cd00096
      Location:321 → 325
      Ig; Ig strand C [structural motif]
      cl11960
      Location:303 → 365
      Ig; Immunoglobulin domain

    4. XM_017593671.3 → XP_017449160.1  matrix metalloproteinase-23 isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O88272.1 GenPept UniProtKB/Swiss-Prot:O88272

    Gene LinkOut

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