Unc13b unc-13 homolog B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Unc13bprovided by RGD
Official Full Name: unc-13 homolog Bprovided by RGD
Primary source: RGD:619723
See related: Ensembl:ENSRNOG00000008237 AllianceGenome:RGD:619723
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Unc13h2; Munc13-2
Summary: Enables calmodulin binding activity and syntaxin-1 binding activity. Involved in several processes, including positive regulation of inhibitory postsynaptic potential; positive regulation of secretion by cell; and secretion by cell. Located in cytosol; synaptic membrane; and terminal bouton. Orthologous to human UNC13B (unc-13 homolog B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 74.9), Heart (RPKM 65.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q22

Exon count:: 47

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (62084809..62299884)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (57288999..57504110)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (58505449..58714396)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Delineating the Molecular Basis of the CalmodulinbMunc13-2 Interaction by Cross-Linking/Mass Spectrometry-Evidence for a Novel CaM Binding Motif in bMunc13-2.
Title: Delineating the Molecular Basis of the Calmodulin‒bMunc13-2 Interaction by Cross-Linking/Mass Spectrometry-Evidence for a Novel CaM Binding Motif in bMunc13-2.
Transport vesicle fusion into PIP2-rich membrane domains is facilitated by sequential PIP2-dependent activation of CAPS and PIP2-dependent recruitment of Munc13.
Title: CAPS and Munc13 utilize distinct PIP2-linked mechanisms to promote vesicle exocytosis.
Rab3A-interacting molecule RIM regulates the presynaptic recruitment of Munc13-1 and ubMunc13-2
Title: Binding to Rab3A-interacting molecule RIM regulates the presynaptic recruitment of Munc13-1 and ubMunc13-2.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH142716 (e-PCR)
- UniSTS:231963

RH134618 (e-PCR)
- UniSTS:217897

AU049544 (e-PCR)
- UniSTS:145991

PMC30485P1 (e-PCR)
- UniSTS:272536

AU046617 (e-PCR)
- UniSTS:111282

RH130683 (e-PCR)
- UniSTS:213967

MARC_17336-17337:1021394418:1 (e-PCR)
- UniSTS:268276

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTP-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calmodulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin binding	IDA Inferred from Direct Assay more info	PubMed
enables diacylglycerol binding	IEA Inferred from Electronic Annotation more info
enables phospholipid binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables syntaxin binding	IDA Inferred from Direct Assay more info	PubMed
enables syntaxin-1 binding	IBA Inferred from Biological aspect of Ancestor more info
enables syntaxin-1 binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in acrosomal vesicle exocytosis	ISO Inferred from Sequence Orthology more info
involved_in cellular response to glucose stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in chemical synaptic transmission	ISS Inferred from Sequence or Structural Similarity more info
NOT involved_in dense core granule docking	ISO Inferred from Sequence Orthology more info
involved_in dense core granule priming	IBA Inferred from Biological aspect of Ancestor more info
involved_in dense core granule priming	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within innervation	ISO Inferred from Sequence Orthology more info
involved_in modulation of chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of synaptic plasticity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuromuscular junction development	ISO Inferred from Sequence Orthology more info
involved_in neuronal dense core vesicle exocytosis	ISO Inferred from Sequence Orthology more info
involved_in neuronal dense core vesicle exocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in phagosome maturation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of defense response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of inhibitory postsynaptic potential	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of protein secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic vesicle priming	IGI Inferred from Genetic Interaction more info	PubMed
involved_in presynaptic dense core vesicle exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in presynaptic dense core vesicle exocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of presynaptic dense core granule exocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of presynaptic dense core granule exocytosis	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of presynaptic dense core granule exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of short-term neuronal synaptic plasticity	ISO Inferred from Sequence Orthology more info
involved_in regulation of short-term neuronal synaptic plasticity	ISO Inferred from Sequence Orthology more info
involved_in spontaneous neurotransmitter secretion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in synaptic transmission, glutamatergic	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within synaptic transmission, glutamatergic	ISO Inferred from Sequence Orthology more info
involved_in synaptic vesicle docking	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within synaptic vesicle docking	ISO Inferred from Sequence Orthology more info
involved_in synaptic vesicle exocytosis	IEA Inferred from Electronic Annotation more info
involved_in synaptic vesicle exocytosis	ISO Inferred from Sequence Orthology more info
involved_in synaptic vesicle priming	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic vesicle priming	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within synaptic vesicle priming	ISO Inferred from Sequence Orthology more info
involved_in synaptic vesicle priming	ISO Inferred from Sequence Orthology more info
involved_in synaptic vesicle priming	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in calyx of Held	ISO Inferred from Sequence Orthology more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in early phagosome	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in hippocampal mossy fiber to CA3 synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in neuromuscular junction	IBA Inferred from Biological aspect of Ancestor more info
located_in neuromuscular junction	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IGI Inferred from Genetic Interaction more info	PubMed
located_in presynapse	IEA Inferred from Electronic Annotation more info
is_active_in presynapse	ISO Inferred from Sequence Orthology more info
located_in presynapse	ISO Inferred from Sequence Orthology more info
located_in presynaptic active zone	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic active zone cytoplasmic component	IBA Inferred from Biological aspect of Ancestor more info
is_active_in presynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in ribbon synapse	ISO Inferred from Sequence Orthology more info
located_in synapse	ISO Inferred from Sequence Orthology more info
located_in synaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in synaptic vesicle membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in terminal bouton	IBA Inferred from Biological aspect of Ancestor more info
located_in terminal bouton	IGI Inferred from Genetic Interaction more info	PubMed

General protein information

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Preferred Names: protein unc-13 homolog B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001042579.2 → NP_001036044.2 protein unc-13 homolog B isoform u

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

Q62769, Q9WV40

Conserved Domains (6) summary

cd04027
Location:613 → 739

C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins

cd08394
Location:1 → 127

C2A_Munc13; C2 domain first repeat in Munc13 (mammalian uncoordinated) proteins

cd08395
Location:1470 → 1589

C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins

pfam06292
Location:931 → 1034

DUF1041; Domain of Unknown Function (DUF1041)

pfam10540
Location:1277 → 1413

Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain

cd20859
Location:472 → 553

C1_Munc13-2-like; protein kinase C conserved region 1 (C1 domain) found in Munc13-2, Munc13-3 and similar proteins
NM_022862.3 → NP_074053.2 protein unc-13 homolog B isoform b

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

Conserved Domains (6) summary

cd04027
Location:976 → 1102

C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins

cd08395
Location:1833 → 1952

C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins

pfam06292
Location:1294 → 1397

DUF1041; Domain of Unknown Function (DUF1041)

pfam10540
Location:1640 → 1776

Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain

cd20859
Location:835 → 916

C1_Munc13-2-like; protein kinase C conserved region 1 (C1 domain) found in Munc13-2, Munc13-3 and similar proteins

cl09111
Location:142 → 222

Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

62084809..62299884

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063288360.1 → XP_063144430.1 protein unc-13 homolog B isoform X9

UniProtKB/Swiss-Prot

Q62769, Q9WV40
XM_039110717.2 → XP_038966645.1 protein unc-13 homolog B isoform X4

UniProtKB/Swiss-Prot

Q62769, Q9WV40

UniProtKB/TrEMBL

A6IJ08

Conserved Domains (6) summary

cd04027
Location:611 → 737

C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins

cd08394
Location:1 → 127

C2A_Munc13; C2 domain first repeat in Munc13 (mammalian uncoordinated) proteins

cd08395
Location:1468 → 1587

C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins

pfam06292
Location:929 → 1032

DUF1041; Domain of Unknown Function (DUF1041)

pfam10540
Location:1275 → 1411

Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain

cd20859
Location:470 → 551

C1_Munc13-2-like; protein kinase C conserved region 1 (C1 domain) found in Munc13-2, Munc13-3 and similar proteins
XM_039110722.2 → XP_038966650.1 protein unc-13 homolog B isoform X6

UniProtKB/Swiss-Prot

Q62769, Q9WV40

UniProtKB/TrEMBL

F1LXM4

Related

ENSRNOP00000046751.4

Conserved Domains (6) summary

cd04027
Location:611 → 737

C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins

cd08394
Location:1 → 127

C2A_Munc13; C2 domain first repeat in Munc13 (mammalian uncoordinated) proteins

cd08395
Location:1449 → 1568

C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins

pfam06292
Location:929 → 1032

DUF1041; Domain of Unknown Function (DUF1041)

pfam10540
Location:1275 → 1411

Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain

cd20859
Location:470 → 551

C1_Munc13-2-like; protein kinase C conserved region 1 (C1 domain) found in Munc13-2, Munc13-3 and similar proteins
XM_039110723.2 → XP_038966651.1 protein unc-13 homolog B isoform X7

UniProtKB/Swiss-Prot

Q62769, Q9WV40

Conserved Domains (6) summary

cd04027
Location:611 → 737

C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins

cd08394
Location:1 → 127

C2A_Munc13; C2 domain first repeat in Munc13 (mammalian uncoordinated) proteins

cd08395
Location:1448 → 1567

C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins

pfam06292
Location:929 → 1031

DUF1041; Domain of Unknown Function (DUF1041)

pfam10540
Location:1274 → 1410

Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain

cd20859
Location:470 → 551

C1_Munc13-2-like; protein kinase C conserved region 1 (C1 domain) found in Munc13-2, Munc13-3 and similar proteins
XM_063288364.1 → XP_063144434.1 protein unc-13 homolog B isoform X11

UniProtKB/TrEMBL

A0A8I6AGA8
XM_039110721.2 → XP_038966649.1 protein unc-13 homolog B isoform X5

UniProtKB/Swiss-Prot

Q62769, Q9WV40

UniProtKB/TrEMBL

D3Z9Y2

Related

ENSRNOP00000058802.4

Conserved Domains (6) summary

cd04027
Location:599 → 725

C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins

cd08394
Location:1 → 127

C2A_Munc13; C2 domain first repeat in Munc13 (mammalian uncoordinated) proteins

cd08395
Location:1456 → 1575

C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins

pfam06292
Location:917 → 1020

DUF1041; Domain of Unknown Function (DUF1041)

pfam10540
Location:1263 → 1399

Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain

cd20859
Location:458 → 539

C1_Munc13-2-like; protein kinase C conserved region 1 (C1 domain) found in Munc13-2, Munc13-3 and similar proteins
XM_039110724.2 → XP_038966652.1 protein unc-13 homolog B isoform X8

UniProtKB/Swiss-Prot

Q62769, Q9WV40

UniProtKB/TrEMBL

A6IJ09

Conserved Domains (6) summary

cd04027
Location:599 → 725

C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins

cd08394
Location:1 → 127

C2A_Munc13; C2 domain first repeat in Munc13 (mammalian uncoordinated) proteins

cd08395
Location:1437 → 1556

C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins

pfam06292
Location:917 → 1020

DUF1041; Domain of Unknown Function (DUF1041)

pfam10540
Location:1263 → 1399

Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain

cd20859
Location:458 → 539

C1_Munc13-2-like; protein kinase C conserved region 1 (C1 domain) found in Munc13-2, Munc13-3 and similar proteins
XM_063288361.1 → XP_063144431.1 protein unc-13 homolog B isoform X10
XM_063288358.1 → XP_063144428.1 protein unc-13 homolog B isoform X1

UniProtKB/TrEMBL

A0A0G2K511, A6IJ10
XM_063288357.1 → XP_063144427.1 protein unc-13 homolog B isoform X1

UniProtKB/TrEMBL

A0A0G2K511, A6IJ10
XM_063288363.1 → XP_063144433.1 protein unc-13 homolog B isoform X10
XM_039110716.2 → XP_038966644.1 protein unc-13 homolog B isoform X3

Conserved Domains (6) summary

cd04027
Location:974 → 1100

C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins

cd08395
Location:1812 → 1931

C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins

pfam06292
Location:1292 → 1395

DUF1041; Domain of Unknown Function (DUF1041)

pfam10540
Location:1638 → 1774

Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain

cd20859
Location:833 → 914

C1_Munc13-2-like; protein kinase C conserved region 1 (C1 domain) found in Munc13-2, Munc13-3 and similar proteins

cl09111
Location:142 → 222

Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
XM_063288359.1 → XP_063144429.1 protein unc-13 homolog B isoform X2