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    Ptprn2 protein tyrosine phosphatase, receptor type N2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29714, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Ptprn2provided by RGD
    Official Full Name
    protein tyrosine phosphatase, receptor type N2provided by RGD
    Primary source
    RGD:61904
    See related
    Ensembl:ENSRNOG00000005003 AllianceGenome:RGD:61904
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    PTPNE6; R-PTP-N2
    Summary
    Predicted to enable protein tyrosine phosphatase activity. Involved in negative regulation of GTPase activity. Located in endoplasmic reticulum lumen; secretory granule; and terminal bouton. Is integral component of synaptic vesicle membrane. Human ortholog(s) of this gene implicated in prediabetes syndrome and type 1 diabetes mellitus. Orthologous to human PTPRN2 (protein tyrosine phosphatase receptor type N2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 258.7) and Adrenal (RPKM 24.0) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ptprn2 in Genome Data Viewer
    Location:
    6q33
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (143582568..144334573)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (137439572..138191575)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (144384773..145133042)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene non-SMC condensin II complex, subunit G2 Neighboring gene uncharacterized LOC102548847 Neighboring gene uncharacterized LOC120093226 Neighboring gene uncharacterized LOC108351315 Neighboring gene uncharacterized LOC134479492 Neighboring gene uncharacterized LOC134479491 Neighboring gene uncharacterized LOC120093227 Neighboring gene microRNA 153 Neighboring gene lactate dehydrogenase A, pseudogene 25 Neighboring gene uncharacterized LOC120093171

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Knockdown of Ptprn-2 delays the onset of puberty in female rats. Kang T, et al. Theriogenology, 2021 Dec. PMID 34607132
    2. Autoantibodies to IA-2beta improve diabetes risk assessment in high-risk relatives. Achenbach P, et al. Diabetologia, 2008 Mar. PMID 18193190
    3. HLA-DQ8-associated T cell responses to the diabetes autoantigen phogrin (IA-2 beta) in human prediabetes. Kelemen K, et al. J Immunol, 2004 Mar 15. PMID 15004204
    4. Spontaneous peripheral T-cell responses to the IA-2beta (phogrin) autoantigen in young nonobese diabetic mice. Achenbach P, et al. J Autoimmun, 2002 Nov. PMID 12419281
    5. Characterization and chromosomal localization of PTP-NP-2, a new isoform of protein tyrosine phosphatase-like receptor, expressed on synaptic boutons. Jiang S, et al. Gene, 1998 Jul 30. PMID 9714834

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Knockdown of Ptprn-2 delays the onset of puberty in female rats.
      Title: Knockdown of Ptprn-2 delays the onset of puberty in female rats.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in insulin secretion involved in cellular response to glucose stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in insulin secretion involved in cellular response to glucose stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in insulin secretion involved in cellular response to glucose stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in insulin secretion involved in cellular response to glucose stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neurotransmitter secretion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neurotransmitter secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neurotransmitter secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum lumen IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in presynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of receptor complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in secretory granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in secretory granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in secretory granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in secretory granule membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in secretory granule membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in secretory granule membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in synaptic vesicle membrane EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in synaptic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synaptic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synaptic vesicle membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in terminal bouton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    receptor-type tyrosine-protein phosphatase N2
    Names
    PTP NE-6
    phogrin
    protein tyrosine phosphatase receptor-type N polypeptide 2
    NP_113788.1
    XP_038967789.1
    XP_038967790.1
    XP_038967791.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031600.2 → NP_113788.1  receptor-type tyrosine-protein phosphatase N2 precursor

      See identical proteins and their annotated locations for NP_113788.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/Swiss-Prot
      Q63475
      UniProtKB/TrEMBL
      A6KDL9
      Related
      ENSRNOP00000006942.4, ENSRNOT00000006942.5
      Conserved Domains (4) summary
      smart00194
      Location:734 → 993
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:761 → 993
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      pfam11548
      Location:501 → 586
      Receptor_IA-2; Protein-tyrosine phosphatase receptor IA-2
      pfam14948
      Location:58 → 113
      RESP18; RESP18 domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      143582568..144334573
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039111861.2 → XP_038967789.1  receptor-type tyrosine-protein phosphatase N2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AHT8
      Related
      ENSRNOP00000093030.1
      Conserved Domains (3) summary
      cd14610
      Location:738 → 1020
      R-PTP-N2; PTP-like domain of receptor-type tyrosine-protein phosphatase N2
      pfam11548
      Location:520 → 608
      Receptor_IA-2; Protein-tyrosine phosphatase receptor IA-2
      pfam14948
      Location:80 → 148
      RESP18; RESP18 domain

    2. XM_039111863.2 → XP_038967791.1  receptor-type tyrosine-protein phosphatase N2 isoform X3

      Conserved Domains (3) summary
      cd14610
      Location:670 → 952
      R-PTP-N2; PTP-like domain of receptor-type tyrosine-protein phosphatase N2
      pfam11548
      Location:452 → 540
      Receptor_IA-2; Protein-tyrosine phosphatase receptor IA-2
      pfam14948
      Location:80 → 148
      RESP18; RESP18 domain

    3. XM_039111862.2 → XP_038967790.1  receptor-type tyrosine-protein phosphatase N2 isoform X2

      Conserved Domains (3) summary
      cd14610
      Location:699 → 981
      R-PTP-N2; PTP-like domain of receptor-type tyrosine-protein phosphatase N2
      pfam11548
      Location:481 → 569
      Receptor_IA-2; Protein-tyrosine phosphatase receptor IA-2
      pfam14948
      Location:41 → 96
      RESP18; RESP18 domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q63475.1 GenPept UniProtKB/Swiss-Prot:Q63475

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