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    Mtarc1 mitochondrial amidoxime reducing component 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 690745, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Mtarc1provided by RGD
    Official Full Name
    mitochondrial amidoxime reducing component 1provided by RGD
    Primary source
    RGD:1592219
    See related
    Ensembl:ENSRNOG00000037850 AllianceGenome:RGD:1592219
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Marc1; Mosc1
    Summary
    Predicted to enable molybdenum ion binding activity; molybdopterin cofactor binding activity; and oxidoreductase activity, acting on other nitrogenous compounds as donors. Predicted to contribute to nitrite reductase (NO-forming) activity. Predicted to be involved in cellular detoxification of nitrogen compound; nitrate metabolic process; and nitric oxide biosynthetic process. Predicted to be located in mitochondrion. Predicted to be part of nitric-oxide synthase complex. Orthologous to human MTARC1 (mitochondrial amidoxime reducing component 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Liver (RPKM 730.7), Kidney (RPKM 188.6) and 2 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mtarc1 in Genome Data Viewer
    Location:
    13q26
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (98854235..98894208, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (96324377..96362677, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (102693679..102724120, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096339 Neighboring gene H2.0-like homeobox Neighboring gene uncharacterized LOC134481538 Neighboring gene mitochondrial amidoxime reducing component 2 Neighboring gene similar to human chromosome 1 open reading frame 115

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of human mARC1 reveals its exceptional position among eukaryotic molybdenum enzymes. Kubitza C, et al. Proc Natl Acad Sci U S A, 2018 Nov 20. PMID 30397129, Free PMC Article
    2. Biochemical and spectroscopic characterization of the human mitochondrial amidoxime reducing components hmARC-1 and hmARC-2 suggests the existence of a new molybdenum enzyme family in eukaryotes. Wahl B, et al. J Biol Chem, 2010 Nov 26. PMID 20861021, Free PMC Article
    3. Proteomic analysis of the mouse liver mitochondrial inner membrane. Da Cruz S, et al. J Biol Chem, 2003 Oct 17. PMID 12865426
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables molybdenum ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molybdenum ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molybdopterin cofactor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molybdopterin cofactor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nitrate reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nitrate reductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to nitrite reductase (NO-forming) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nitrite reductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity, acting on other nitrogenous compounds as donors ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular detoxification of nitrogen compound ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nitrate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nitrate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nitric oxide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nitric-oxide synthase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial amidoxime-reducing component 1
    Names
    MOCO sulphurase C-terminal domain containing 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100811.1 → NP_001094281.1  mitochondrial amidoxime-reducing component 1

      See identical proteins and their annotated locations for NP_001094281.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A6JGP5, D3Z900, G3V6I4
      Related
      ENSRNOP00000034963.6, ENSRNOT00000029439.7
      Conserved Domains (3) summary
      COG3217
      Location:60 → 339
      YcbX; Uncharacterized conserved protein YcbX, contains MOSC and Fe-S domains [General function prediction only]
      pfam03473
      Location:207 → 336
      MOSC; MOSC domain
      pfam03476
      Location:58 → 179
      MOSC_N; MOSC N-terminal beta barrel domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      98854235..98894208 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039091110.2 → XP_038947038.1  mitochondrial amidoxime-reducing component 1 isoform X2

      UniProtKB/TrEMBL
      A6JGP6
      Conserved Domains (1) summary
      COG3217
      Location:60 → 299
      YcbX; Uncharacterized conserved protein YcbX, contains MOSC and Fe-S domains [General function prediction only]

    2. XM_063272629.1 → XP_063128699.1  mitochondrial amidoxime-reducing component 1 isoform X1

      UniProtKB/TrEMBL
      A6JGP6
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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    Chemical Information
    Molecular Biology Databases
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