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    Art1 ADP-ribosyltransferase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308873, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Art1provided by RGD
    Official Full Name
    ADP-ribosyltransferase 1provided by RGD
    Primary source
    RGD:1304591
    See related
    Ensembl:ENSRNOG00000020251 AllianceGenome:RGD:1304591
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable NAD+ ADP-ribosyltransferase activity. Predicted to be involved in peptidyl-arginine ADP-ribosylation. Predicted to act upstream of or within protein ADP-ribosylation. Predicted to be located in cell surface. Predicted to be anchored component of membrane. Orthologous to human ART1 (ADP-ribosyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward (RPKM 689.3) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Art1 in Genome Data Viewer
    Location:
    1q32
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (165890032..165899154)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (156478096..156487172)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (167202064..167206615)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene ring finger protein 121 Neighboring gene Xrcc1 N-terminal domain containing 1 Neighboring gene transient receptor potential cation channel subfamily C member 2 Neighboring gene ADP-ribosyltransferase 5 Neighboring gene cholinergic receptor nicotinic alpha 10 subunit Neighboring gene nucleoporin 98 and 96 precursor Neighboring gene glutathione peroxidase 4, pseudogene 1 Neighboring gene post-GPI attachment to proteins 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning of a functional murine arginine-specific mono-ADP-ribosyltransferase and its expression in lymphoid cells. Yu Y, et al. DNA Cell Biol, 1997 Feb. PMID 9052744
    2. Prostate cancer progression, metastasis, and gene expression in transgenic mice. Perez-Stable C, et al. Cancer Res, 1997 Mar 1. PMID 9041192
    3. Molecular characterization of a glycosylphosphatidylinositol-linked ADP-ribosyltransferase from lymphocytes. Okazaki IJ, et al. Blood, 1996 Aug 1. PMID 8704249
    4. Cloning and characterization of a novel membrane-associated lymphocyte NAD:arginine ADP-ribosyltransferase. Okazaki IJ, et al. J Biol Chem, 1996 Sep 6. PMID 8703012
    5. Structure, chromosomal localization, and expression of the gene for mouse ecto-mono(ADP-ribosyl)transferase ART5. Glowacki G, et al. Gene, 2001 Sep 19. PMID 11587854

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables NAD+ ADP-ribosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NAD+ ADP-ribosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables NAD+-protein-arginine ADP-ribosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1
    NP_001101011.1
    XP_038969297.1
    XP_038969298.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107541.2 → NP_001101011.1  GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1

      See identical proteins and their annotated locations for NP_001101011.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6I716, D3ZJK0
      Related
      ENSRNOP00000027427.5, ENSRNOT00000027427.7
      Conserved Domains (1) summary
      pfam01129
      Location:39 → 269
      ART; NAD:arginine ADP-ribosyltransferase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      165890032..165899154
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039113369.2 → XP_038969297.1  GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 isoform X1

      UniProtKB/TrEMBL
      A6I716, D3ZJK0
      Conserved Domains (1) summary
      pfam01129
      Location:39 → 269
      ART; NAD:arginine ADP-ribosyltransferase

    2. XM_039113370.2 → XP_038969298.1  GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 isoform X1

      UniProtKB/TrEMBL
      A6I716, D3ZJK0
      Conserved Domains (1) summary
      pfam01129
      Location:39 → 269
      ART; NAD:arginine ADP-ribosyltransferase
    Nucleotide Protein Strain
    Heading Accession and Version

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