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    Arhgap27 Rho GTPase activating protein 27 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303583, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Arhgap27provided by RGD
    Official Full Name
    Rho GTPase activating protein 27provided by RGD
    Primary source
    RGD:735202
    See related
    Ensembl:ENSRNOG00000028569 AllianceGenome:RGD:735202
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    CAMGAP1; Arhgap15
    Summary
    Enables GTPase activator activity and SH3 domain binding activity. Involved in positive regulation of GTPase activity. Acts upstream of or within receptor-mediated endocytosis. Located in endosome. Orthologous to human ARHGAP27 (Rho GTPase activating protein 27). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 78.1), Thymus (RPKM 62.0) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Arhgap27 in Genome Data Viewer
    Location:
    10q32.1
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (88780527..88813275, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (88280470..88313225, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (91418535..91451831, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095296 Neighboring gene spermatogenesis associated 32 Neighboring gene mitogen-activated protein kinase kinase kinase 14 Neighboring gene uncharacterized LOC120095297 Neighboring gene uncharacterized LOC134480883 Neighboring gene pleckstrin homology and RUN domain containing M1 Neighboring gene uncharacterized LOC134480884 Neighboring gene leucine rich repeat containing 37A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of a novel Rho GTPase activating protein implicated in receptor-mediated endocytosis. Sakakibara T, et al. FEBS Lett, 2004 May 21. PMID 15147912
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables SH3 domain binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Rho protein signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within receptor-mediated endocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in receptor-mediated endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    rho GTPase-activating protein 27
    Names
    CIN85-associated multi-domain containing RhoGAP 1
    CIN85-associated multi-domain-containing Rho GTPase-activating protein 1
    Rho GTPase activating protein 15
    rho-type GTPase-activating protein 27

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198759.2 → NP_942054.2  rho GTPase-activating protein 27

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      Q6TLK4
      UniProtKB/TrEMBL
      F1LQ24

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      88780527..88813275 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063269176.1 → XP_063125246.1  rho GTPase-activating protein 27 isoform X2

      UniProtKB/Swiss-Prot
      Q6TLK4

    2. XM_063269174.1 → XP_063125244.1  rho GTPase-activating protein 27 isoform X1

      UniProtKB/Swiss-Prot
      Q6TLK4
      UniProtKB/TrEMBL
      F1LQ24

    3. XM_063269175.1 → XP_063125245.1  rho GTPase-activating protein 27 isoform X1

      UniProtKB/Swiss-Prot
      Q6TLK4
      UniProtKB/TrEMBL
      F1LQ24

    4. XM_008768291.4 → XP_008766513.1  rho GTPase-activating protein 27 isoform X5

      Conserved Domains (4) summary
      cd04403
      Location:331 → 517
      RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
      cd13233
      Location:136 → 250
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam00169
      Location:136 → 249
      PH; PH domain
      pfam00397
      Location:74 → 101
      WW; WW domain

    5. XM_063269177.1 → XP_063125247.1  rho GTPase-activating protein 27 isoform X4

      UniProtKB/TrEMBL
      A6HJR0

    6. XM_006247525.5 → XP_006247587.1  rho GTPase-activating protein 27 isoform X3

      UniProtKB/TrEMBL
      A0A8I6GK79, A6HJR0
      Related
      ENSRNOP00000092531.1
      Conserved Domains (4) summary
      cd04403
      Location:476 → 662
      RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
      cd13233
      Location:281 → 395
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam00169
      Location:281 → 394
      PH; PH domain
      pfam00397
      Location:49 → 79
      WW; WW domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6TLK4.1 GenPept UniProtKB/Swiss-Prot:Q6TLK4

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