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    Garnl3 GTPase activating Rap/RanGAP domain-like 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 499783, updated on 22-May-2024

    Summary

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    Official Symbol
    Garnl3provided by RGD
    Official Full Name
    GTPase activating Rap/RanGAP domain-like 3provided by RGD
    Primary source
    RGD:1564019
    See related
    Ensembl:ENSRNOG00000057044 AllianceGenome:RGD:1564019
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1564019
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in activation of GTPase activity. Predicted to be active in cytoplasm. Orthologous to human GARNL3 (GTPase activating Rap/RanGAP domain like 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 109.1), Kidney (RPKM 30.5) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Garnl3 in Genome Data Viewer
    Location:
    3p11
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (36686388..36830011, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (16288718..16432308, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (12034131..12176591, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, H/ACA box 65 Neighboring gene ribosomal protein L12 Neighboring gene uncharacterized LOC120101525 Neighboring gene solute carrier family 2 member 8 Neighboring gene Ral GEF with PH domain and SH3 binding motif 1 Neighboring gene angiopoietin-like 2 Neighboring gene zinc finger and BTB domain containing 34

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of small GTPase mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    GTPase activating Rap/RanGAP domain-like 3; GTPase-activating Rap/Ran-GAP domain-like protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001430652.1 → NP_001417581.1  GTPase activating Rap/RanGAP domain-like 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    2. NM_001430653.1 → NP_001417582.1  GTPase activating Rap/RanGAP domain-like 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    3. NM_001430654.1 → NP_001417583.1  GTPase activating Rap/RanGAP domain-like 3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    4. NM_001430655.1 → NP_001417584.1  GTPase activating Rap/RanGAP domain-like 3 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    5. NM_001430656.1 → NP_001417585.1  GTPase activating Rap/RanGAP domain-like 3 isoform 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    6. NM_001430657.1 → NP_001417586.1  GTPase activating Rap/RanGAP domain-like 3 isoform 6

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    7. NM_001430658.1 → NP_001417587.1  GTPase activating Rap/RanGAP domain-like 3 isoform 7

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    8. NM_001430659.1 → NP_001417588.1  GTPase activating Rap/RanGAP domain-like 3 isoform 7

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    9. NM_001430660.1 → NP_001417589.1  GTPase activating Rap/RanGAP domain-like 3 isoform 7

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    10. NM_001430661.1 → NP_001417590.1  GTPase activating Rap/RanGAP domain-like 3 isoform 7

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    11. NM_001430662.1 → NP_001417591.1  GTPase activating Rap/RanGAP domain-like 3 isoform 7

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    12. NM_001430663.1 → NP_001417592.1  GTPase activating Rap/RanGAP domain-like 3 isoform 8

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    13. NM_001430664.1 → NP_001417593.1  GTPase activating Rap/RanGAP domain-like 3 isoform 9

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      36686388..36830011 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039106188.2 → XP_038962116.1  GTPase-activating Rap/Ran-GAP domain-like protein 3 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JX90
      Conserved Domains (2) summary
      pfam00780
      Location:552 → 857
      CNH; CNH domain
      pfam02145
      Location:280 → 458
      Rap_GAP; Rap/ran-GAP

    2. XM_063284843.1 → XP_063140913.1  GTPase-activating Rap/Ran-GAP domain-like protein 3 isoform X3

      UniProtKB/TrEMBL
      A0A8I6ALW8

    3. XM_063284848.1 → XP_063140918.1  GTPase-activating Rap/Ran-GAP domain-like protein 3 isoform X3

      UniProtKB/TrEMBL
      A0A8I6ALW8

    4. XM_063284845.1 → XP_063140915.1  GTPase-activating Rap/Ran-GAP domain-like protein 3 isoform X5

    5. XM_039106187.2 → XP_038962115.1  GTPase-activating Rap/Ran-GAP domain-like protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JX90
      Related
      ENSRNOP00000094574.1
      Conserved Domains (2) summary
      pfam00780
      Location:556 → 861
      CNH; CNH domain
      pfam02145
      Location:284 → 462
      Rap_GAP; Rap/ran-GAP

    6. XM_063284849.1 → XP_063140919.1  GTPase-activating Rap/Ran-GAP domain-like protein 3 isoform X3

      UniProtKB/TrEMBL
      A0A8I6ALW8

    7. XM_039106201.2 → XP_038962129.1  GTPase-activating Rap/Ran-GAP domain-like protein 3 isoform X9

      UniProtKB/TrEMBL
      A0A8I5ZUD1
      Conserved Domains (2) summary
      pfam00780
      Location:324 → 629
      CNH; CNH domain
      pfam02145
      Location:52 → 230
      Rap_GAP; Rap/ran-GAP

    8. XM_039106197.2 → XP_038962125.1  GTPase-activating Rap/Ran-GAP domain-like protein 3 isoform X9

      UniProtKB/TrEMBL
      A0A8I5ZUD1
      Conserved Domains (2) summary
      pfam00780
      Location:324 → 629
      CNH; CNH domain
      pfam02145
      Location:52 → 230
      Rap_GAP; Rap/ran-GAP

    9. XM_039106200.2 → XP_038962128.1  GTPase-activating Rap/Ran-GAP domain-like protein 3 isoform X9

      UniProtKB/TrEMBL
      A0A8I5ZUD1
      Conserved Domains (2) summary
      pfam00780
      Location:324 → 629
      CNH; CNH domain
      pfam02145
      Location:52 → 230
      Rap_GAP; Rap/ran-GAP

    10. XM_039106195.2 → XP_038962123.1  GTPase-activating Rap/Ran-GAP domain-like protein 3 isoform X6

      UniProtKB/TrEMBL
      A0A8I5ZUD1, A0A8I6A905
      Related
      ENSRNOP00000086495.1
      Conserved Domains (2) summary
      pfam00780
      Location:471 → 776
      CNH; CNH domain
      pfam02145
      Location:199 → 377
      Rap_GAP; Rap/ran-GAP

    11. XM_063284850.1 → XP_063140920.1  GTPase-activating Rap/Ran-GAP domain-like protein 3 isoform X9

    12. XM_039106202.2 → XP_038962130.1  GTPase-activating Rap/Ran-GAP domain-like protein 3 isoform X9

      UniProtKB/TrEMBL
      A0A8I5ZUD1
      Conserved Domains (2) summary
      pfam00780
      Location:324 → 629
      CNH; CNH domain
      pfam02145
      Location:52 → 230
      Rap_GAP; Rap/ran-GAP

    13. XM_039106198.2 → XP_038962126.1  GTPase-activating Rap/Ran-GAP domain-like protein 3 isoform X9

      UniProtKB/TrEMBL
      A0A8I5ZUD1
      Conserved Domains (2) summary
      pfam00780
      Location:324 → 629
      CNH; CNH domain
      pfam02145
      Location:52 → 230
      Rap_GAP; Rap/ran-GAP

    14. XM_063284846.1 → XP_063140916.1  GTPase-activating Rap/Ran-GAP domain-like protein 3 isoform X7

    15. XM_063284844.1 → XP_063140914.1  GTPase-activating Rap/Ran-GAP domain-like protein 3 isoform X4

    16. XM_063284847.1 → XP_063140917.1  GTPase-activating Rap/Ran-GAP domain-like protein 3 isoform X8

    RNA

    1. XR_010064757.1 RNA Sequence

    2. XR_010064759.1 RNA Sequence

    3. XR_010064758.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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