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    Rab17 RAB17, member RAS oncogene family [ Rattus norvegicus (Norway rat) ]

    Gene ID: 503269, updated on 25-Apr-2024

    Summary

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    Official Symbol
    Rab17provided by RGD
    Official Full Name
    RAB17, member RAS oncogene familyprovided by RGD
    Primary source
    RGD:1562478
    See related
    Ensembl:ENSRNOG00000052979 AllianceGenome:RGD:1562478
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1562478
    Summary
    Predicted to enable GDP binding activity and GTPase activity. Predicted to be involved in several processes, including immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor; plasma membrane bounded cell projection assembly; and regulation of plasma membrane bounded cell projection organization. Predicted to be located in several cellular components, including apical plasma membrane; basolateral plasma membrane; and cytoplasmic vesicle. Predicted to be active in early endosome; plasma membrane; and recycling endosome membrane. Orthologous to human RAB17 (RAB17, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 321.9), Liver (RPKM 163.7) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rab17 in Genome Data Viewer
    Location:
    9q36
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (99001044..99014340, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (91552924..91566759, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (98118907..98131883, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene melanophilin Neighboring gene prolactin releasing hormone Neighboring gene LRR binding FLII interacting protein 1 Neighboring gene RNA binding motif protein 44

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Rab17 regulates apical delivery of hepatic transcytotic vesicles. Striz AC, et al. Mol Biol Cell, 2018 Nov 15. PMID 30256711, Free PMC Article
    2. Small GTPase Rab17 regulates dendritic morphogenesis and postsynaptic development of hippocampal neurons. Mori Y, et al. J Biol Chem, 2012 Mar 16. PMID 22291024, Free PMC Article
    3. Rab17 regulates membrane trafficking through apical recycling endosomes in polarized epithelial cells. Zacchi P, et al. J Cell Biol, 1998 Mar 9. PMID 9490718, Free PMC Article
    4. Rab17 localizes to recycling endosomes and regulates receptor-mediated transcytosis in epithelial cells. Hunziker W, et al. J Biol Chem, 1998 Jun 19. PMID 9624171
    5. Rab17, a novel small GTPase, is specific for epithelial cells and is induced during cell polarization. Lütcke A, et al. J Cell Biol, 1993 May. PMID 8486736, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Authors determined that transcytosis of three classes of newly synthesized apical residents showed similar responses to rab17 mutant expression, indicating that rab17 is a general component of the transcytotic machinery required for apically destined vesicle docking and fusion.
      Title: Rab17 regulates apical delivery of hepatic transcytotic vesicles.
    2. These data suggest that Rab17 mediates the dendritic trafficking of Syntaxin-4 to selectively regulate dendritic surface insertion of GluK2-containing KARs in rat hippocampal neurons.
      Title: Small GTPase Rab17 regulates the surface expression of kainate receptors but not α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors in hippocampal neurons via dendritic trafficking of Syntaxin-4 protein.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GDP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in anterograde dendritic transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endocytic recycling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytic recycling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT involved_in endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in establishment of melanosome localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in filopodium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in melanosome transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of dendrite development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of filopodium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of synapse assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in melanosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in recycling endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in recycling endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in recycling endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ras-related protein Rab-17

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109363.2 → NP_001102833.1  ras-related protein Rab-17

      See identical proteins and their annotated locations for NP_001102833.1

      Status: PROVISIONAL

      Source sequence(s)
      BC167022
      UniProtKB/TrEMBL
      A0A0G2JTD9, A0A9K3Y7P9, B2RZ46
      Related
      ENSRNOP00000068669.2, ENSRNOT00000079446.2
      Conserved Domains (1) summary
      cd01860
      Location:21 → 181
      Rab5_related; Rab-related GTPase family includes Rab5 and Rab22; regulates early endosome fusion

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      99001044..99014340 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039084134.2 → XP_038940062.1  ras-related protein Rab-17 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JTD9, A0A9K3Y7P9, B2RZ46
      Conserved Domains (1) summary
      cd01860
      Location:21 → 181
      Rab5_related; Rab-related GTPase family includes Rab5 and Rab22; regulates early endosome fusion

    2. XM_039084135.2 → XP_038940063.1  ras-related protein Rab-17 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JTD9, A0A9K3Y7P9, B2RZ46
      Conserved Domains (1) summary
      cd01860
      Location:21 → 181
      Rab5_related; Rab-related GTPase family includes Rab5 and Rab22; regulates early endosome fusion
    Nucleotide Protein Strain
    Heading Accession and Version

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