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    Mob3a MOB kinase activator 3A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362833, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Mob3aprovided by RGD
    Official Full Name
    MOB kinase activator 3Aprovided by RGD
    Primary source
    RGD:1308187
    See related
    Ensembl:ENSRNOG00000018971 AllianceGenome:RGD:1308187
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mobkl2a; Mobkl2b
    Summary
    Predicted to enable protein kinase activator activity. Predicted to be involved in positive regulation of protein phosphorylation and signal transduction. Predicted to be active in cytoplasm and nucleus. Orthologous to human MOB3A (MOB kinase activator 3A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 149.6), Thymus (RPKM 103.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mob3a in Genome Data Viewer
    Location:
    7q11
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (9661185..9678584)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (9010490..9027888)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (11878943..11896226)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479808 Neighboring gene adaptor related protein complex 3 subunit delta 1 Neighboring gene uncharacterized LOC120093774 Neighboring gene IZUMO family member 4 Neighboring gene SUMO-conjugating enzyme UBC9-B-like Neighboring gene MAPK interacting serine/threonine kinase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    MOB kinase activator 3A
    Names
    MOB1, Mps One Binder kinase activator-like 2A
    MOB1, Mps One Binder kinase activator-like 2B
    mps one binder kinase activator-like 2A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108734.2 → NP_001102204.1  MOB kinase activator 3A

      See identical proteins and their annotated locations for NP_001102204.1

      Status: PROVISIONAL

      Source sequence(s)
      BC168845
      UniProtKB/TrEMBL
      B5DEX8, F7F4P5
      Related
      ENSRNOP00000025634.5, ENSRNOT00000025634.6
      Conserved Domains (1) summary
      pfam03637
      Location:36 → 208
      Mob1_phocein; Mob1/phocein family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      9661185..9678584
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063263743.1 → XP_063119813.1  MOB kinase activator 3A isoform X1

    2. XM_039079395.1 → XP_038935323.1  MOB kinase activator 3A isoform X2

      UniProtKB/TrEMBL
      B5DEX8, F7F4P5
      Conserved Domains (1) summary
      pfam03637
      Location:36 → 208
      Mob1_phocein; Mob1/phocein family

    3. XM_006240963.5 → XP_006241025.1  MOB kinase activator 3A isoform X2

      See identical proteins and their annotated locations for XP_006241025.1

      UniProtKB/TrEMBL
      B5DEX8, F7F4P5
      Conserved Domains (1) summary
      pfam03637
      Location:36 → 208
      Mob1_phocein; Mob1/phocein family
    Nucleotide Protein Strain
    Heading Accession and Version

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